[**] CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED PORTIONS. BLOOD SCREENING HIV PROBE LICENSE AGREEMENT between CHIRON CORPORATION F. HOFFMANN-LA ROCHE LTD. and ROCHE MOLECULAR SYSTEMS, INC. BLOOD SCREENING HIV PROBE LICENSE AGREEMENT TABLE OF CONTENTS Page RECITALS 3 ARTICLE 1: DEFINITIONS 3 ARTICLE 2: LICENSE AND OPTION GRANTS 7 ARTICLE 3: PAYMENTS, ROYALTIES 9 ARTICLE 4: RECORDS AND REPORTS 9 ARTICLE 5: OTHER ACTIONS 12 ARTICLE 6: REPRESENTATIONS AND WARRANTIES 12 ARTICLE 7: TERM AND TERMINATION 13 ARTICLE 8: CONFIDENTIALITY 15 ARTICLE 9: INDEMNITY 16 ARTICLE 10: ALTERNATIVE DISPUTE RESOLUTION 16 ARTICLE 11: MISCELLANEOUS 18 ARTICLE 12: FIELD RESTRICTIONS AND OTHER COVENANTS 20 ARTICLE 13: INFRINGEMENT BY THIRD PARTIES 21 ARTICLE 14: EUROPEAN COMMUNITY PROVISIONS 22 EXHIBIT A: COMPENSATION TO CHIRON EXHIBIT B: CHIRON PATENT LIST EXHIBIT C: ROCHE PATENT LIST EXHIBIT D: CHIRON LICENSED PRODUCTS EXHIBIT E: FORM OF REPORT EXHIBIT F: EXISTING LICENSES EXHIBIT G: REGIONS 2 BLOOD SCREENING HIV PROBE LICENSE AGREEMENT This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608 (hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and ROCHE MOLECULAR SYSTEMS, INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT, "ROCHE"). BACKGROUND WHEREAS, CHIRON and ROCHE currently own or control certain patent rights relating to the human immunodeficiency virus ("HIV"), as defined below. WHEREAS, CHIRON and ROCHE entered into that certain Settlement Agreement dated as of October 10, 2000 (the "Settlement Agreement") pertaining to the settlement of the certain litigation matters described therein. WHEREAS, in consideration of and subject to the execution and delivery of the Settlement Agreement, CHIRON granted licenses to ROCHE under certain patent rights relating to HIV for use in assays for the detection of nucleic acid sequences for use in Blood Screening, subject to certain geographic and time limitations, under that certain Blood Screening HCV/HIV Probe License Agreement dated as of October 10, 2000 (the "Interim Agreement"). WHEREAS, CHIRON and ROCHE now desire to enter into a long term, worldwide collaboration in Blood Screening, superceding the terms and conditions of the Interim Agreement, all on the terms and conditions set forth herein. NOW, THEREFORE, in consideration of the above provisions and the mutual covenants contained herein, CHIRON and ROCHE hereby agree as follows: ARTICLE 1 DEFINITIONS In this Agreement the following words and phrases shall have the following meanings: 1.1 "ADR" means Alternative Dispute Resolution in accordance with
Blood Screening HIV Probe License Agreement - Chiron Corp., F. Hoffman-La Roche Ltd. and Roche Molecular Systems Inc.
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