{"id":41643,"date":"2015-09-17T11:25:58","date_gmt":"2015-09-17T16:25:58","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-legal\/contracts\/uncategorized\/limited-liability-company-agreement-merck-capital-ventures-llc.html"},"modified":"2015-09-17T11:25:58","modified_gmt":"2015-09-17T16:25:58","slug":"limited-liability-company-agreement-merck-capital-ventures-llc","status":"publish","type":"corporate_contracts","link":"https:\/\/corporate.findlaw.com\/contracts\/formation\/limited-liability-company-agreement-merck-capital-ventures-llc.html","title":{"rendered":"Limited Liability Company Agreement &#8211; Merck Capital Ventures LLC"},"content":{"rendered":"<pre>\n                                                                  Execution Copy\n\n\n\n\n                       LIMITED LIABILITY COMPANY AGREEMENT\n\n                                       OF\n\n                           MERCK CAPITAL VENTURES, LLC\n\n\n                          Dated as of November 27, 2000\n                          -----------------------------\n\n \n                                TABLE OF CONTENTS\n\n<\/pre>\n<table>\n<caption>\n                                                                                      Page<br \/>\n<s>                                                                                   <c><br \/>\nARTICLE 1   DEFINITIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.1<br \/>\n            &#8212;&#8212;&#8212;&#8211;<\/p>\n<p>ARTICLE 2   FORMATION; TERM; FISCAL YEAR&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..1<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n            2.1.     Formation&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;1<br \/>\n            2.2.     Term&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..2<br \/>\n            2.3.     Fiscal Year&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.2<\/p>\n<p>ARTICLE 3   NAME AND PLACE OF BUSINESS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.2<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n            3.1.     Name&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..2<br \/>\n            3.2.     Principal Place of Business&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;2<\/p>\n<p>ARTICLE 4   PURPOSE AND POWERS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;2<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n            4.1.     Purpose&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..2<br \/>\n            4.2.     Powers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;2<\/p>\n<p>ARTICLE 5   CAPITAL CONTRIBUTIONS; MEMBERSHIP INTERESTS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..3<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n            5.1.     Capital Contributions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;3<br \/>\n            5.2.     Notice and Funding of Capital Contributions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..4<br \/>\n            5.4.     No Return of Capital Contributions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..5<br \/>\n            5.5.     Designated Additional Carry Members&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.5<\/p>\n<p>ARTICLE 6   BOARD OF MANAGERS AND OFFICERS OF THE COMPANY&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;6<br \/>\n&#8212;&#8212;&#8212;   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n            6.1.     Designation of Board of Managers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.6<br \/>\n            6.2.     Election; Resignation; Removal&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;7<br \/>\n            6.3.     Board Action&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;7<br \/>\n            6.4.     Meetings&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.7<br \/>\n            6.5.     Quorum&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;8<br \/>\n            6.6.     Action By Consent&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.8<br \/>\n            6.7.     Telephonic Meetings&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..8<br \/>\n            6.8.     Managers as Agents&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;8<br \/>\n            6.9.     Powers of the Board&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..8<br \/>\n            6.10.    Reimbursement&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..8<br \/>\n            6.11.    Non-Exclusive Engagement&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;9<br \/>\n            6.12.    Officers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.9<br \/>\n            6.13.    Certain Actions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..10<br \/>\n            6.14.    Reliance by Third Parties&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.12<br \/>\n            6.15.    No Right to Manage&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..12<\/p>\n<p>ARTICLE 7   RIGHTS AND OBLIGATIONS OF LOFBERG&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..12<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n            7.1.     Powers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..12<br \/>\n<\/c><\/s><\/caption>\n<\/table>\n<p>                                      -i-<\/p>\n<table>\n<s>                                                                                   <c><br \/>\n            7.2.     Consultation with Investment Committee&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;13<\/p>\n<p>ARTICLE 8   OTHER AGREEMENTS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.13<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n            8.1.     The Investment Committee and the Executive Committee&#8230;&#8230;&#8230;&#8230;.13<br \/>\n            8.2.     Other Investments&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;14<br \/>\n            8.3.     Certain Other Fees&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..16<br \/>\n            8.4.     MCV Budget&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.17<br \/>\n            8.5.     Administrative Staff&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;18<br \/>\n            8.6.     Fees and Expenses; Carry Member Costs&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.18<\/p>\n<p>ARTICLE 9   ACCOUNTS AND ALLOCATIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..18<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n            9.1.     Capital Accounts&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.18<br \/>\n            9.2.     Allocations&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;19<br \/>\n            9.3.     Tax Allocations&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..20<\/p>\n<p>ARTICLE 10  DISTRIBUTIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.21<br \/>\n            &#8212;&#8212;&#8212;&#8212;-<br \/>\n            10.1.    Distributions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.21<br \/>\n            10.2.    Certain Other Distributions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..22<br \/>\n            10.3     Distributions in Kind&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..24<br \/>\n            10.4.    Withholding Requirements&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..25<br \/>\n            10.5.    Valuations&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.25<\/p>\n<p>ARTICLE 11  TRANSFER OF MEMBERSHIP INTERESTS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;26<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n            11.1.    Transfers&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..26<br \/>\n            11.2.    Ownership of Membership Interests&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..27<\/p>\n<p>ARTICLE 12  WITHDRAWAL; DISSOLUTION AND LIQUIDATION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..27<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n            12.1.    Withdrawal of Members&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..27<br \/>\n            12.3.    Liquidation&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;27<br \/>\n            12.4.    Return of Excess Distributions to Investor Members&#8230;&#8230;&#8230;&#8230;&#8230;28<\/p>\n<p>ARTICLE 13  TAX MATTERS; CERTAIN REPRESENTATIONS OF MEMBERS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;29<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n            13.1.    Designation of Tax Matters Member&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..29<br \/>\n            13.2.    Tax Returns&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;29<br \/>\n            13.3.    Taxable Year&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..29<br \/>\n            13.4.    Tax Elections&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.29<br \/>\n            13.5.    Certain Representations of Members&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.29<\/p>\n<p>ARTICLE 14  BOOKS OF ACCOUNT; REPORTS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.31<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n            14.1.    Books of Account&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.31<br \/>\n            14.2.    Reports to Members&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..31<br \/>\n            14.3.    Final Accounting&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.31<br \/>\n<\/c><\/s><\/table>\n<p>                                     -ii-<\/p>\n<table>\n<s>                                                                                   <c><br \/>\nARTICLE 15  LIMITATION ON LIABILITY; INDEMNIFICATION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.32<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n            15.1.    Limitation on Members&#8217; Liability&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;32<br \/>\n            15.2.    Limitation on Protected Parties&#8217; Liability&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..32<br \/>\n            15.3.    Indemnification of the Protected Parties&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.32<br \/>\n            15.4.    No Liability for Acts of Agents&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.32<br \/>\n            15.5.    General&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\n            15.6.    Survival&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;33<\/p>\n<p>ARTICLE 16  MISCELLANEOUS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\n            &#8212;&#8212;&#8212;&#8212;-<br \/>\n            16.1.    Special Power of Attorney&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\n            16.2.    Amendments&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\n            16.3.    Binding Effects; Benefits&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.34<br \/>\n            16.4.    Headings&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;34<br \/>\n            16.5.    Counterparts&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\n            16.6.    Grammatical Construction&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\n            16.7.    Separability&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\n            16.8.    Waiver&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\n            16.9.    Entire Agreement&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.35<br \/>\n            16.10.  Notices&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..35<br \/>\n            16.11.   Insurance&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..35<br \/>\n            16.12.   Disclosure of Investment&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..36<br \/>\n            16.13.   Arbitration&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;36<br \/>\n            16.14.  Appointment of Executive Agent&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;37<br \/>\n            16.15.   Payments on Business Days&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.37<br \/>\n            16.16.  Governing Law&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..38<br \/>\n<\/c><\/s><\/table>\n<p>APPENDIX A        Definitions<\/p>\n<p>                       LIMITED LIABILITY COMPANY AGREEMENT<\/p>\n<p>                                       OF<\/p>\n<p>                           MERCK CAPITAL VENTURES, LLC<\/p>\n<p>      LIMITED LIABILITY COMPANY AGREEMENT of Merck Capital Ventures, LLC (the<br \/>\n&#8220;Company&#8221;), dated as of November 27, 2000, by and among Merck-Medco Managed<br \/>\n  &#8212;&#8212;<br \/>\nCare, L.L.C. (&#8220;Merck&#8221;), the individuals listed on Part A of Schedule A hereto<br \/>\n               &#8212;&#8211;                              &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n(the &#8220;Other Investor Members&#8221; and together with Merck, the &#8220;Investor Members&#8221;)<br \/>\n      &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-                                &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nand the individuals listed on Part B of Schedule A hereto (the &#8220;Carry Members&#8221;<br \/>\n                              &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;              &#8212;&#8212;&#8212;&#8212;-<br \/>\nand together with the Investor Members, the &#8220;Members&#8221;).<br \/>\n                                             &#8212;&#8212;-<\/p>\n<p>      WHEREAS, the Company was formed by the filing of a Certificate of<br \/>\nFormation with the Secretary of State of the State of Delaware; and<\/p>\n<p>      WHEREAS, the Members desire to enter into this Limited Liability Company<br \/>\nAgreement (the &#8220;Agreement&#8221;) in accordance with the provisions of the Delaware<br \/>\n                &#8212;&#8212;&#8212;<br \/>\nLimited Liability Company Act (the &#8220;LLC Act&#8221;) in order to set forth the rights<br \/>\n                                    &#8212;&#8212;-<br \/>\nand obligations of the Members.<\/p>\n<p>      NOW, THEREFORE, the parties hereto hereby agree as follows:<\/p>\n<p>                                    ARTICLE 1<\/p>\n<p>                                   DEFINITIONS<br \/>\n                                   &#8212;&#8212;&#8212;&#8211;<\/p>\n<p>      Certain capitalized terms used herein are defined in Appendix A attached<br \/>\n                                                           &#8212;&#8212;&#8212;-<br \/>\nhereto and made a part hereof.<\/p>\n<p>                                    ARTICLE 2<\/p>\n<p>                          FORMATION; TERM; FISCAL YEAR<br \/>\n                          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>      2.1. Formation. The Members hereby acknowledge the formation of the<br \/>\n           &#8212;&#8212;&#8212;<br \/>\nCompany as a limited liability company pursuant to the LLC Act by virtue of the<br \/>\nfiling of a Certificate of Formation with the Secretary of State of the State of<br \/>\nDelaware, and confirm and agree to their status as Members of the Company. The<br \/>\nMembers hereby execute this Agreement for the purpose of establishing the<br \/>\nrights, duties and relationship of the Members.<\/p>\n<p>      2.2. Term. This Agreement shall continue until the Company is dissolved<br \/>\n           &#8212;-<br \/>\nand liquidated in accordance with the provisions of Article 12 hereof.<\/p>\n<p>                                      -1-<\/p>\n<p>      2.3. Fiscal Year. Unless the Board of Managers at any time shall otherwise<br \/>\n           &#8212;&#8212;&#8212;&#8211;<br \/>\ndetermine or with respect to the last fiscal year of the Company, the fiscal<br \/>\nyear of the Company (the &#8220;Fiscal Year&#8221;) shall end on December 31. The initial<br \/>\n                          &#8212;&#8212;&#8212;&#8211;<br \/>\nFiscal Year shall commence on the date hereof and end on December 31, 2000.<\/p>\n<p>                                    ARTICLE 3<\/p>\n<p>                           NAME AND PLACE OF BUSINESS<br \/>\n                           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>      3.1. Name. The name of the Company shall be, and the business of the<br \/>\n           &#8212;-<br \/>\nCompany shall be conducted under the name, &#8220;Merck Capital Ventures, LLC&#8221;;<br \/>\n                                            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nprovided that such name shall be subject to change, from time to time, by the<br \/>\nBoard of Managers.<\/p>\n<p>      3.2. Principal Place of Business. The principal place of business of the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nCompany shall be at such place as the Board of Managers shall determine from<br \/>\ntime to time. The Board of Managers shall notify the Members of any change of<br \/>\nthe principal place of business of the Company. The Company may maintain such<br \/>\noffice or offices for the transaction of business at such other locations as the<br \/>\nBoard of Managers may deem advisable.<\/p>\n<p>                                    ARTICLE 4<\/p>\n<p>                               PURPOSE AND POWERS<br \/>\n                               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      4.1. Purpose. The purpose of the Company is to purchase, invest or<br \/>\n           &#8212;&#8212;-<br \/>\notherwise acquire or engage in investments of no more than 20% (unless otherwise<br \/>\napproved by the Board of Managers) in the equity of (a) Clinical Development<br \/>\nEntities and (b) private internet and other private emerging businesses engaged<br \/>\nin the businesses of (i) improving the quality and\/or reducing the cost of<br \/>\ncommercialization, distribution and delivery of pharmaceuticals and healthcare<br \/>\nservices related thereto, or (ii) exploiting data derived therefrom (together<br \/>\nwith Clinical Development Entities, &#8220;E-Healthcare Companies&#8221;) and such other<br \/>\n                                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\ninvestments in private companies as may be approved by the Board of Managers or<br \/>\nare made in accordance with Section 7.1(a) and to engage in any and all<br \/>\nactivities that are reasonably related thereto, provided, however, that the<br \/>\n                                                &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nCompany may not invest in entities engaged in research based pharmaceutical,<br \/>\nvaccine or biotech businesses.<\/p>\n<p>      4.2. Powers. The Company shall have and may exercise all the powers and<br \/>\n           &#8212;&#8212;<br \/>\nprivileges to the fullest extent permitted by law as are necessary, appropriate<br \/>\nor incidental to the conduct, promotion or attainment of the purpose of the<br \/>\nCompany, including, without limitation:<\/p>\n<p>      (a) to purchase, sell, possess, transfer, or otherwise deal in, and to<br \/>\nexercise all rights, powers, privileges and other incidents of ownership or<br \/>\npossession with<\/p>\n<p>                                      -2-<\/p>\n<p>respect to, the equity, assets and businesses of E-Healthcare Companies and<br \/>\nother investments or of any of their respective successors or assigns;<\/p>\n<p>      (b) to have and maintain one or more offices and, in connection therewith,<br \/>\nto rent or acquire office space and furnishings, engage personnel and do such<br \/>\nother acts and things as may be necessary or advisable in connection with the<br \/>\nmaintenance of such office or offices;<\/p>\n<p>      (c) to open, maintain and close bank accounts and to draw checks or other<br \/>\norders for the payment of moneys;<\/p>\n<p>      (d) to enter into, perform and carry out contracts and agreements of every<br \/>\nkind necessary or incidental to the accomplishment of the Company&#8217;s purpose, and<br \/>\nto take or omit to take such other or further action in connection with the<br \/>\nCompany&#8217;s business as may be necessary or desirable in the opinion of the Board<br \/>\nof Managers to further the purpose of the Company;<\/p>\n<p>      (e) to invest such funds as are temporarily not required for Company<br \/>\npurposes in short-term high-grade investments selected by the Board of Managers,<br \/>\nincluding money market accounts, short-term investment funds, government<br \/>\nsecurities, certificates of deposit of commercial banks (domestic or foreign),<br \/>\ncommercial paper, bankers&#8217; acceptances and other money market instruments; and<\/p>\n<p>      (f) to carry on any other activities necessary to, in connection with, or<br \/>\nincidental to any of the foregoing.<\/p>\n<p>                                    ARTICLE 5<\/p>\n<p>                   CAPITAL CONTRIBUTIONS; MEMBERSHIP INTERESTS<br \/>\n                   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>      5.1. Capital Contributions. (a) Merck agrees to contribute to the Company<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nup to $100 million for investments in Portfolio Investments (the &#8220;Merck Base<br \/>\n                                                                  &#8212;&#8212;&#8212;-<br \/>\nCommitment&#8221;) as and when called by the Company in accordance with the terms of<br \/>\n&#8212;&#8212;&#8212;-<br \/>\nthis Agreement, and to contribute additional amounts to pay certain Fees and<br \/>\nExpenses of the Company as set forth in Section 5.1(b), and each Other Investor<br \/>\nMember agrees to contribute to the Company in respect of each Portfolio<br \/>\nInvestment in which Merck invests the Merck Base Commitment (including without<br \/>\nlimitation any follow on Portfolio Investments in a Portfolio Company), an<br \/>\namount calculated by multiplying the Ratable Contribution Percentage of such<br \/>\nInvestor Member expressed as a decimal multiplied by the lesser of (i) 10% of<br \/>\nthe Acquisition Cost of such Portfolio Investment (or follow on Portfolio<br \/>\nInvestment as the case may be) or (ii) $1,000,000 (the &#8220;Other Investor Members<br \/>\n                                                        &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nBase Commitment&#8221;), in accordance with the terms of this Agreement (collectively<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nwith the Merck contributions, the &#8220;Capital Contributions&#8221;). Except as specified<br \/>\n                                   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nby this Agreement or as required by applicable law, (i) no Member shall at any<br \/>\ntime be required <\/p>\n<p>                                      -3-<\/p>\n<p>to make any additional contribution to the capital of the Company or any loans<br \/>\nto the Company, (ii) no Investor Member (other than Merck) shall be obligated to<br \/>\nmake a Capital Contribution in respect of a Portfolio Investment made or<br \/>\ncommitted to be made before the Start Date of such Investor Member or after the<br \/>\nEnd Date of such Investor Member, and (iii) the Aggregate Capital Contributions<br \/>\nof the Other Investor Members shall not exceed $10 million.<\/p>\n<p>      (b) Capital Contributions shall be called and used (i) during the<br \/>\nInvestment Period, to fund Portfolio Investments (including follow on<br \/>\ninvestments) and (ii) during the Expenses Period (including both during and<br \/>\nafter the Investment Period), to pay all reasonable Fees and Expenses of the<br \/>\nCompany.<\/p>\n<p>      (c) Notwithstanding the provisions of Sections 5.1(a) and (b), (i) each<br \/>\nInvestor Member&#8217;s obligation to fund its Capital Contributions (other than the<br \/>\nCapital Contributions set out in Section 5.1(b)(ii)) will expire at the end of<br \/>\nthe Investment Period and (ii) Merck&#8217;s obligation to fund Capital Contributions<br \/>\nin accordance with Section 5.1(b)(ii) will expire at the end of the Expenses<br \/>\nPeriod.<\/p>\n<p>      5.2. Notice and Funding of Capital Contributions. (a) On each occasion<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nthat the Company proposes to make an investment in a Portfolio Company in which<br \/>\na Capital Contribution is required, the Company shall give to each Investor<br \/>\nMember who is eligible to participate in such Capital Contribution a written<br \/>\nnotice at least 10 days prior to the date such Capital Contribution is required<br \/>\n(a &#8220;Funding Notice&#8221;) which shall include (i) a brief description of the<br \/>\n    &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ntransaction (including a reasonable description of the form and structure<br \/>\nthereof) or purpose for which such Capital Contributions are required, (ii) the<br \/>\naggregate amount of Capital Contributions required and the respective Investor<br \/>\nMember&#8217;s share thereof, (iii) the date by which such Capital Contributions are<br \/>\nrequired to be funded, and (iv) if applicable, the account of the Portfolio<br \/>\nCompany to which such Capital Contributions shall be made.<\/p>\n<p>           (b) During the Expenses Period, Merck will contribute to the Company<br \/>\nas a Capital Contribution from time to time as may be reasonably required<br \/>\namounts sufficient to pay all anticipated Fees and Expenses as provided in the<br \/>\nMCV Budget. In addition, from time to time during the Expenses Period, Merck<br \/>\nwill contribute to the Company as a Capital Contribution an amount equal to any<br \/>\nBreak-Up Expenses or other Fees and Expenses required to be contributed by Merck<br \/>\nto the Company in accordance with this Agreement.<\/p>\n<p>           (c) Each Investor Member shall deposit its required Capital<br \/>\nContributions, in immediately available funds, in the account of the Company or<br \/>\nof the Portfolio Company, as the case requires, within the time period specified<br \/>\nin the Funding Notice. If an Investor Member deposits its required Capital<br \/>\nContribution later than the last day specified in the Funding Notice, and the<br \/>\nCompany incurs any costs or expenses <\/p>\n<p>                                      -4-<\/p>\n<p>(including, without limitation, interest expenses) as a result of such late<br \/>\ndeposit, then such Investor Member shall pay to the Company an additional amount<br \/>\nequal to the amount of such costs and expenses (and such additional amount shall<br \/>\nnot be considered Capital Contributions). If an Investor Member shall Default in<br \/>\nall or any portion of their contribution obligations as set forth in the Funding<br \/>\nNotice, the Company shall give to the other Investor Members (&#8220;Non-Defaulting<br \/>\n                                                               &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nInvestor Members&#8221;) a further written notice, which shall include the amount of<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nthe deficiency in the required Capital Contributions. The majority of the<br \/>\nNon-Defaulting Investor Members may either, (i) agree to pay the full amount of<br \/>\nthe deficiency in the required Capital Contribution (in such proportion as is<br \/>\nagreed by such Non-Defaulting Investor Members) or (ii) agree that the Company<br \/>\nnot proceed with the Portfolio Investment the subject of the Funding Notice in<br \/>\nwhich case, the Company will refund to the Investor Members the full amount of<br \/>\nall Capital Contributions made by the Investor Members in respect of such<br \/>\nPortfolio Investment.<\/p>\n<p>      5.3. Voting Rights. (a) The Investor Members shall have Membership<br \/>\n           &#8212;&#8212;&#8212;&#8212;-<br \/>\nInterests in the Company in the amounts representing their respective Capital<br \/>\nContributions. All such Membership Interests shall be of a single class for<br \/>\npurposes of the LLC Act&#8217;s voting requirements.<\/p>\n<p>      (b) The Carry Members shall be Members entitled to distributions in<br \/>\naccordance with this Agreement. However, except as provided in Sections 5.5(b)<br \/>\nand 16.2, the Membership Interests of the Carry Members shall not entitle them<br \/>\nto vote on any matter as a Member.<\/p>\n<p>      5.4. No Return of Capital Contributions. Except as provided in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n12.4 hereof, no Member is entitled to a withdrawal or return of its Capital<br \/>\nContributions to the Company, but each shall look solely to distributions from<br \/>\nthe Company for such purpose.<\/p>\n<p>      5.5. Designated Additional Carry Members. (a) At any time and from time to<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ntime, Merck or, for so long as Lofberg is Chief Executive Officer of the<br \/>\nCompany, Lofberg may propose to the Board of Managers, and the Board of Managers<br \/>\nmay designate in accordance with and subject to the provisions of Sections<br \/>\n5.5(c) and 6.13, an additional Person as a &#8220;Designated Additional Carry Member&#8221;.<br \/>\n                                            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nUpon designation of a Designated Additional Carry Member, the Board of Managers<br \/>\nwill in accordance with the provisions of Section 6.13 specify the Applicable<br \/>\nCarried Interest applicable to such Designated Additional Carry Member and such<br \/>\nDesignated Additional Carry Member shall be admitted to the Company as a Carry<br \/>\nMember; provided, however, that the sum of the Maximum Amount of all Carry<br \/>\n        &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nMembers shall not exceed 20%. Each Designated Additional Carry Member shall be<br \/>\ndeemed a Carry Member for the purposes of this Agreement, and his or her<br \/>\ninterest in the LLC and right to distribution shall be subject to all<br \/>\nrestrictions imposed upon a Carry Member hereunder.<\/p>\n<p>                                      -5-<\/p>\n<p>      (b) Upon the designation of a Designated Additional Carry Member as a<br \/>\nCarry Member in accordance with Section 5.5(a), the Other Investor Members<br \/>\nshall, with the prior written consent of Merck, reallocate the Ratable<br \/>\nContribution Percentages of each of the Other Investor Members, provided,<br \/>\n                                                                &#8212;&#8212;&#8211;<br \/>\nhowever, that (i) for so long as Lofberg is the Chief Executive Officer of the<br \/>\n&#8212;&#8212;-<br \/>\nCompany, the aggregate of all Ratable Contribution Percentages will be 100%, and<br \/>\n(ii) if Lofberg ceases to be the Chief Executive Officer, the aggregate of all<br \/>\nRatable Contribution Percentages shall not be less than the aggregate of the<br \/>\nRatable Contribution Percentages of all of the Carry Members other than Lofberg<br \/>\nexisting immediately prior to the time Lofberg ceases to be the Chief Executive<br \/>\nOfficer. Upon the allocation of a Ratable Contribution Percentage in accordance<br \/>\nwith and subject to the provisions of this Section 5.5(b) and Section 5.5(c) to<br \/>\na Designated Additional Carry Member, such Designated Additional Carry Member<br \/>\nshall be admitted to the Company as an Investor Member.<\/p>\n<p>      (c) Notwithstanding anything in this Agreement to the contrary, no<br \/>\namendment of this Agreement or allocation or reallocation of Membership<br \/>\nInterests shall reduce the Carry Interest of any Carry Member or change the<br \/>\nRatable Contribution Percentage of any Other Investor Member without the prior<br \/>\nwritten consent of the affected Member.<\/p>\n<p>                                    ARTICLE 6<br \/>\n                                    &#8212;&#8212;&#8212;<\/p>\n<p>                  BOARD OF MANAGERS AND OFFICERS OF THE COMPANY<br \/>\n                  &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      6.1. Designation of Board of Managers.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>      (a) Except as otherwise provided in Section 7.1, the management of the<br \/>\nCompany&#8217;s business shall be vested in a Board of Managers (the &#8220;Board of<br \/>\n                                                                &#8212;&#8212;&#8211;<br \/>\nManagers&#8221; or the &#8220;Board&#8221;). The Board shall consist of a number of Managers (the<br \/>\n&#8212;&#8212;&#8211;          &#8212;&#8211;<br \/>\n&#8220;Managers&#8221;) determined in accordance with this Section 6.1. A Manager need not<br \/>\n &#8212;&#8212;&#8211;<br \/>\nbe a Member.<\/p>\n<p>      (b) The Board shall consist of up to five Managers as determined by Merck,<br \/>\nthe appointment of which shall be determined as follows:<\/p>\n<p>           (i)  so long as Lofberg is the Chief Executive Officer of the<br \/>\n   Company, Lofberg shall be a Manager; and<\/p>\n<p>           (ii) all other Managers shall be designated by Merck from time to<br \/>\n   time. The initial Managers designated by Merck shall be Judy Lewent, Ken<br \/>\n   Frazier, Richard Clark and David Anstice.<\/p>\n<p>      (c)  The Managers serving on the Board shall not be entitled to receive<br \/>\nfees for serving on the Board.<\/p>\n<p>                                      -6-<\/p>\n<p>      (d)  The Board shall elect one of the Managers to act as Chairman (the<br \/>\n&#8220;Chairman&#8221;. The Initial Chairman of the Board of Managers shall be Judy Lewent.<br \/>\n &#8212;&#8212;&#8211;<\/p>\n<p>      6.2. Election; Resignation; Removal.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      (a) Each Manager shall serve from the effective date of his or her<br \/>\ndesignation until the effective date of his or her resignation or removal.<br \/>\nExcept as provided in Section 6.2(c) hereof, in the event any Manager ceases to<br \/>\nbe a Manager of the Company, whether by resignation or removal as provided in<br \/>\nthis Agreement or otherwise, a successor Manager shall be designated by the<br \/>\nparties that were entitled, pursuant to Section 6.1(b), to designate the former<br \/>\nManager.<\/p>\n<p>      (b) A Manager may resign from his or her position as a Manager at any time<br \/>\nupon not less than 10 days&#8217; prior written notice to each of the other Managers<br \/>\nand Merck.<\/p>\n<p>      (c) A Manager may be removed only by the parties that designated such<br \/>\nManager provided, however that Lofberg shall (unless otherwise determined by the<br \/>\n        &#8212;&#8212;&#8211;<br \/>\nBoard of Managers) be removed as a Manager immediately upon his ceasing to be<br \/>\nthe Chief Executive Officer of the Company. The parties requiring the removal of<br \/>\na Manager may specify an effective date for such removal; otherwise, all such<br \/>\nremovals shall be effective immediately.<\/p>\n<p>      6.3. Board Action. Unless otherwise specified in this Agreement, the Board<br \/>\n           &#8212;&#8212;&#8212;&#8212;<br \/>\nshall act by majority vote of those Managers present at the meeting, with each<br \/>\nManager on the Board having one vote.<\/p>\n<p>      6.4. Meetings. The Board may hold regular meetings and in any event<br \/>\n           &#8212;&#8212;&#8211;<br \/>\nquarterly without call or notice at such places and at such times as the Board<br \/>\nmay from time to time determine, provided that reasonable notice of the first<br \/>\nregular meeting following any such determination is given to Managers absent at<br \/>\nthe meeting fixing regular meetings. When called by the Chairman, Chief<br \/>\nExecutive Officer or Managers holding a majority of the votes on the Board, the<br \/>\nBoard may hold special meetings at such places and times as are designated in<br \/>\nthe notice of such special meeting, upon at least seven days&#8217; notice given by<br \/>\nthe Secretary or an Assistant Secretary, or by the Officer or Manager calling<br \/>\nthe special meeting.<\/p>\n<p>      6.5. Quorum. At any meeting of the Board, the presence of three Managers<br \/>\n           &#8212;&#8212;<br \/>\nincluding the Chief Executive Officer shall constitute a quorum. Any meeting may<br \/>\nbe adjourned from time to time by a majority of votes, whether or not a quorum<br \/>\nis present, and the meeting may be held as adjourned upon reasonable notice.<\/p>\n<p>      6.6. Action By Consent. Any action of the Board may be taken without a<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nmeeting if (i) all of the Managers unanimously consent to the action in writing,<br \/>\nand (ii)<\/p>\n<p>                                      -7-<\/p>\n<p>the written consent is filed with the records of the meetings of the Board.<br \/>\nSuch actions by consent shall be treated for all purposes as actions taken at a<br \/>\nmeeting.<\/p>\n<p>      6.7. Telephonic Meetings. Managers may participate in a meeting of the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nBoard by means of a conference telephone or similar communications equipment,<br \/>\nprovided that all Managers participating in the meeting can hear each other at<br \/>\nthe same time. Participation by such means shall constitute presence in person<br \/>\nat a meeting.<\/p>\n<p>      6.8. Managers as Agents. The Managers, to the extent of the powers set<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nforth herein, are agents of the Company for the purpose of the Company&#8217;s<br \/>\nbusiness, and the actions of the Managers taken in accordance with such powers<br \/>\nshall bind the Company.<\/p>\n<p>      6.9. Powers of the Board.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>           (a) The Board&#8217;s powers on behalf and in respect of the Company,<br \/>\nsubject to the provisions of this Agreement requiring the approval of the<br \/>\nMembers and those powers delegated to Lofberg in accordance with Section 7 of<br \/>\nthis Agreement, shall be all powers and privileges permitted to be exercised by<br \/>\nmanagers of a limited liability company under the LLC Act, including, without<br \/>\nlimitation, (i) Section 18-402 of the LLC Act, (ii) the revocation or<br \/>\nsuspension, at any time, of the powers granted to Lofberg or any other Officer<br \/>\npursuant this Agreement or otherwise and (iii) the approval of the MCV Budget;<br \/>\nprovided, however, that nothing herein shall supersede, limit or otherwise<br \/>\n&#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\ninvalidate any action, authorization or resolution of the Members set forth in<br \/>\nthis Agreement.<\/p>\n<p>           (b) The Board may delegate any of its powers to the Executive<br \/>\nCommittee or, except as otherwise required by Section 6.13, the Investment<br \/>\nCommittee. Any powers not delegated by the Board shall remain with the Board.<\/p>\n<p>      6.10. Reimbursement. The Company shall reimburse each Manager and Officer<br \/>\n            &#8212;&#8212;&#8212;&#8212;-<br \/>\nfor all reasonable and necessary out-of-pocket expenses incurred by such Manager<br \/>\nor Officer on behalf of the Company according to such terms, as shall be<br \/>\napproved by the Board. Such reimbursement shall be treated as an expense of the<br \/>\nCompany that shall be deducted in computing Net Profits and shall not be deemed<br \/>\nto constitute a distributive share of Net Profits or a distribution or return of<br \/>\ncapital to any Manager or Officer that is also a Member.<\/p>\n<p>      6.11. Non-Exclusive Engagement. Subject to Section 7, the services of the<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nManagers to the Company hereunder are not to be deemed exclusive and the<br \/>\nManagers shall be free to render similar or other services to others, so long as<br \/>\nsuch Managers&#8217; services hereunder are not impaired thereby, and to retain for<br \/>\ntheir own use and benefit fees or other moneys payable thereby. The Managers<br \/>\nshall not be deemed to be affected with notice of or to be under any duty to<br \/>\ndisclose to the Company any fact or thing which <\/p>\n<p>                                      -8-<\/p>\n<p>may come to the notice of the Managers in the course of the Managers rendering<br \/>\nsimilar services to others, or in the course of its business in any other<br \/>\ncapacity, or in any manner whatsoever other than in the course of carrying out<br \/>\nits duties hereunder; provided, however, that the Managers shall give notice to<br \/>\n                      &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\neach of the Members of any matter that comes to their attention that would<br \/>\nreasonably be expected to have a material adverse effect on the Company or the<br \/>\nability of the Board of Managers to perform its duties under this Agreement.<\/p>\n<p>      6.12. Officers.<br \/>\n            &#8212;&#8212;&#8211;<\/p>\n<p>           (a) General. The Board may appoint agents and employees of the<br \/>\n               &#8212;&#8212;-<br \/>\nCompany who are designated as Officers of the Company. The Officers of the<br \/>\nCompany shall include a President, one or more Vice Presidents, a Treasurer and<br \/>\na Secretary with the duties and authority described below and such officers,<br \/>\nwith such titles, duties and authority as may be approved by the Board from time<br \/>\nto time. The same person may hold any number of offices. Each of the Officers<br \/>\nshall be agents of the Company. The appointment of Officers shall not limit in<br \/>\nany respect the power and authority of the Managers to take any action on behalf<br \/>\nof the Company as provided in this Agreement.<\/p>\n<p>           (b) Resignation; Removal. Each Officer shall hold office until his or<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nher successor shall have been duly elected and shall have qualified, or until<br \/>\nhis or her death, or until he or she shall have resigned or have been removed,<br \/>\nas hereinafter provided. The Board may remove any Officer so appointed at any<br \/>\ntime, with or without Cause, in its absolute discretion.<\/p>\n<p>           (c) President. The President shall be the chief executive officer of<br \/>\n               &#8212;&#8212;&#8212;<br \/>\nthe Company, and shall be responsible for the general and active management of<br \/>\nthe business of the Company and shall see that all orders and resolutions of the<br \/>\nBoard are carried into effect. Except to the extent otherwise provided in this<br \/>\nAgreement or in a resolution of the Board of Managers, the President shall have<br \/>\nsuch other duties and have such other powers as are similar to those of a<br \/>\npresident and chief executive officer of a business corporation organized under<br \/>\nthe LLC Act. Lofberg will be the initial President of the Company.<\/p>\n<p>           (d) Vice President. Each Vice President shall perform all such duties<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nas from time to time may be assigned to him by the Board or the President.<\/p>\n<p>           (e) Treasurer. The Treasurer shall have the care and custody of the<br \/>\n               &#8212;&#8212;&#8212;<br \/>\nfunds and valuable documents of the Company and shall have oversight and<br \/>\nadministrative responsibility for raising and borrowing funds and establishing<br \/>\nbanking and similar relationships and, in general, perform all duties incident<br \/>\nto the office of Treasurer and such other duties as from time to time may be<br \/>\nassigned to him or her by the Board. In the event that any Officer other than<br \/>\nthe Treasurer shall be designated as the <\/p>\n<p>                                      -9-<\/p>\n<p>Company&#8217;s Chief Financial Officer, the Treasurer shall share the foregoing<br \/>\npowers and duties with such Chief Financial Officer, and all references herein<br \/>\nto the Treasurer shall be deemed to include such Chief Financial Officer of the<br \/>\nCompany.<\/p>\n<p>           (f) Secretary. The Secretary shall: (i) keep or cause to be kept in<br \/>\n               &#8212;&#8212;&#8212;<br \/>\none or more books provided for the purpose, the minutes of all meetings and<br \/>\nconsents of the Board; (ii) see that all notices are duly given in accordance<br \/>\nwith the provisions of this Agreement and as required by law; (iii) be custodian<br \/>\nof the records of the Company; (iv) see that the books, reports, statements,<br \/>\ncertificates and other documents and records required by law to be kept and<br \/>\nfiled are properly kept and filed; and (v) in general, perform all duties<br \/>\nincident to the office of Secretary and such other duties as from time to time<br \/>\nmay be assigned to him or her by the Board.<\/p>\n<p>           (g) Subordinate Officers. The Board from time to time may delegate to<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nany Officers the power to appoint subordinate officers or agents and to<br \/>\nprescribe their respective rights, terms of office, authorities and duties. Any<br \/>\nsuch Officer may remove any such subordinate officer or agent appointed by him<br \/>\nor her, for or without Cause.<\/p>\n<p>           (h) Fiduciary Duties of Officers. Except as otherwise provided<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nherein, each Officer shall have fiduciary duties of loyalty and care similar to<br \/>\nthose of officers of business corporations organized under the General<br \/>\nCorporation Law of the State of Delaware.<\/p>\n<p>      6.13. Certain Actions. Without limiting the generality of Section 6.1(a),<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nnone of the following actions may be taken by or on behalf of the Company<br \/>\nwithout prior approval of the Board or the Executive Committee, including, for<br \/>\nso long as Lofberg is the Chief Executive Officer of the Company, the<br \/>\naffirmative vote of Lofberg, in the case of any matter described in clauses (g),<br \/>\n(h) (i) and (j) and any matter described in clause (k) if the annual<br \/>\ncompensation of such employee would exceed $150,000:<\/p>\n<p>           (a) approval of the MCV Budget and expenditures or capital<br \/>\ncommitments other than those authorized under Section 7.1 or otherwise contained<br \/>\nin the MCV Budget;<\/p>\n<p>           (b) creating, incurring or assuming any indebtedness (including,<br \/>\nwithout limitation, any loans by the Members or any of their Affiliates to the<br \/>\nCompany) or entering into any guarantees;<\/p>\n<p>           (c) mortgaging or creating any liens on any assets;<\/p>\n<p>           (d) entering into any employment agreement or amending or waiving any<br \/>\nprovision of any employment agreement;<\/p>\n<p>                                     -10-<\/p>\n<p>           (e) selling or disposing of any Portfolio Investment or other<br \/>\nmaterial assets;<\/p>\n<p>           (f) commencing or settling any legal actions;<\/p>\n<p>           (g) investing in a Portfolio Investment in an amount exceeding $10<br \/>\nmillion or if all Portfolio Investments in the same Portfolio Company would<br \/>\nexceed $20 million in the aggregate;<\/p>\n<p>           (h) investing in a Portfolio Investment of any entity that is a<br \/>\nClinical Development Entity;<\/p>\n<p>           (i) reviewing and approving or disapproving any changes in investment<br \/>\nstrategy and scope;<\/p>\n<p>           (j) reviewing and approving or disapproving the designation of any<br \/>\nDesignated Additional Carry Member and the allocation and reallocation of all<br \/>\nApplicable Carried Interests and Ratable Contribution Percentages;<\/p>\n<p>           (k) determining the compensation payable to any employee of the<br \/>\nCompany, including without limitation, any Designated Additional Carry Members<br \/>\nand any employees of Merck or its Affiliates selected to provide services to the<br \/>\nCompany in accordance with Section 8.5;<\/p>\n<p>           (l) terminating the designation of any Carry Member or Designated<br \/>\nAdditional Carry Member as a Carry Member of the Company (it being understood<br \/>\nthat the employer of such Person retains the absolute authority to terminate<br \/>\nsuch Person&#8217;s employment);<\/p>\n<p>           (m) permitting the Other Investor Members to contribute, in respect<br \/>\nof an individual Portfolio Investment, an aggregate amount in excess of the<br \/>\nlesser of (A) 10% of the Acquisition Cost or (B) $1,000,000 of a Portfolio<br \/>\nInvestment;<\/p>\n<p>           (n) reviewing and approving or disapproving any potential conflicts<br \/>\nof interest of the Members;<\/p>\n<p>           (o) reviewing and approving or disapproving any transaction involving<br \/>\nthe Company and a Portfolio Company in which any Member, a Manager or their<br \/>\nrespective Affiliates has or may have a material interest; or<\/p>\n<p>           (p) reviewing and approving or disapproving any settlement of any<br \/>\nclaim with respect to which any Manager, Officer, Members or any Affiliate of<br \/>\nany of them intends to seek indemnification pursuant to Section 15.<\/p>\n<p>                                     -11-<\/p>\n<p>            Notwithstanding any other provision of the Agreement, so long as<br \/>\nLofberg is a Member of the Company, if the Company shall take any of the actions<br \/>\ndescribed in clauses (a), (b) or (c) of this Section 6.13 without Lofberg&#8217;s<br \/>\nprior written consent, distributions to the Carry Members shall be calculated<br \/>\nwithout giving effect to such actions if the effect of such actions would<br \/>\notherwise be to reduce a Carry Member&#8217;s return in respect of any Portfolio<br \/>\nInvestment.<\/p>\n<p>      6.14. Reliance by Third Parties. Third parties dealing with the Company<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nmay rely conclusively upon any certificate of the Board of Managers or any<br \/>\nOfficer to the effect that it is acting on behalf of the Company. The signature<br \/>\nof the Board of Managers or any Officer shall be sufficient to bind the Company<br \/>\nin every manner to any agreement or on any document.<\/p>\n<p>      6.15. No Right to Manage. Except as otherwise expressly provided for in<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthis Agreement or with the consent of the Board of Managers, the Members shall<br \/>\nnot have any right to take part in the management of the business, affairs or<br \/>\nproperties of the Company or any right or authority to act for or bind the<br \/>\nCompany and shall have only the rights and powers expressly granted to the<br \/>\nMembers hereunder.<\/p>\n<p>                                    ARTICLE 7<\/p>\n<p>                        RIGHTS AND OBLIGATIONS OF LOFBERG<br \/>\n                        &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      7.1.  Powers. For so long as Lofberg is the Chief Executive Officer of the<br \/>\n            &#8212;&#8212;<br \/>\nCompany and has not had his investment authority revoked or suspended by the<br \/>\nBoard of Managers, Lofberg shall have the authority and power on behalf and in<br \/>\nrespect of the Company, without the need for approval from the Board of<br \/>\nManagers, to:<\/p>\n<p>      (a)   make Portfolio Investments in amounts not exceeding $10 million in<br \/>\nany one Portfolio Investment and, when aggregated with all other Portfolio<br \/>\nInvestments in the same Portfolio Company, not exceeding $20 million; provided,<br \/>\n                                                                      &#8212;&#8212;&#8211;<br \/>\n(i) Lofberg shall have consulted with the Board of Managers or the Executive<br \/>\nCommittee regarding the timing and accounting implications to Merck of such<br \/>\ninvestment to the extent feasible and, in all cases, if the investment, together<br \/>\nwith all other Portfolio Investments consummated by the Company in a Quarter<br \/>\nwould exceed $15 million, (ii) such Portfolio Investment shall not result in the<br \/>\nCompany acquiring in excess of 20% of the equity of a Portfolio Company, and<br \/>\n(iii) any Portfolio Investment in a Clinical Development Entity shall require<br \/>\napproval of the Board of Managers or Executive Committee following consultation<br \/>\nwith Merck Research Laboratories.<\/p>\n<p>                                     -12-<\/p>\n<p>      (b) incur reasonable Break-Up Expenses and such other Fees and Expenses as<br \/>\nare necessary to manage the Portfolio Investments in accordance with the MCV<br \/>\nBudget or as otherwise authorized by this Agreement.<\/p>\n<p>      7.2. Consultation with Investment Committee. In the exercise of the powers<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nconferred on him by Section 7.1, Lofberg will on a regular basis inform the<br \/>\nmembers of the Investment Committee of Portfolio Investments made and proposed<br \/>\nto be made and provide members of the Investment Committee with such information<br \/>\nwithin the Company&#8217;s possession concerning each such Portfolio Investment or<br \/>\nproposed Portfolio Investment, as well as such other information within the<br \/>\nCompany&#8217;s possession as any member of the Investment Committee may request.<\/p>\n<p>                                    ARTICLE 8<\/p>\n<p>                                OTHER AGREEMENTS<br \/>\n                                &#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>      8.1. The Investment Committee and the Executive Committee. (a) The Board<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nof Managers will from time to time appoint an Investment Committee which shall<br \/>\nconsist of Lofberg, so long as he is Chief Executive Officer of the Company, and<br \/>\nother members of the Board of Managers, Officers of the Company and other<br \/>\nPersons, as determined by the Board of Managers. The initial members of the<br \/>\nInvestment Committee will be Lofberg, Cooper, Jon Filderman, Richard Kender,<br \/>\nPaul Howes and one person designated by Merck. The Board of Managers may remove<br \/>\nany member of the Investment Committee at any time. The Investment Committee<br \/>\nshall meet as necessary. Members of the Investment Committee may participate in<br \/>\nmeetings of the Investment Committee in person, by proxy, or by telephonic<br \/>\nconference call in which all participants can hear each other.<\/p>\n<p>      (b) The functions of the Investment Committee will be to consult with and<br \/>\nprovide investment advice on proposed investments to the Officers, Board of<br \/>\nManagers and the Members, including in regard to any proposed commercial<br \/>\narrangements with Merck. To assist the Investment Committee, the Officers of the<br \/>\nCompany will review all aspects of each proposed investment including<br \/>\nsuitability of investment candidates, results of due diligence, terms of<br \/>\nproposed investments, expected synergies and analysis of competitive effects<br \/>\nand, following such review, will present such information and analysis to the<br \/>\nInvestment Committee for its review.<\/p>\n<p>      (c) Other than as expressly set forth in this Agreement, the<br \/>\nrecommendations of the Investment Committee shall be advisory only and shall not<br \/>\nobligate the Members or the Board of Managers to act or refrain from acting in<br \/>\naccordance therewith. Neither the Investment Committee nor any member thereof,<br \/>\nin his or her capacity as such, may act on behalf of or may bind the Company in<br \/>\nany manner. The Company shall be responsible for all reasonable out-of-pocket<br \/>\nexpenses incurred by <\/p>\n<p>                                     -13-<\/p>\n<p>members of the Investment Committee in connection with fulfilling their<br \/>\nresponsibilities to the Investment Committee.<\/p>\n<p>      (d) The Board of Managers will from time to time appoint an executive<br \/>\ncommittee of not more than 3 Persons which shall consist of members of the Board<br \/>\nof Managers, Officers of the Company and other Persons, as determined by the<br \/>\nBoard of Managers (the &#8220;Executive Committee&#8221;), provided, however that, for so<br \/>\n                        &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-    &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nlong as Lofberg is Chief Executive Officer of the Company, he will be a member<br \/>\nof the Executive Committee. The initial members of the Executive Committee will<br \/>\nbe Lofberg, Judy Lewent and Ken Frazier. Subject to the proviso in the first<br \/>\nsentence of this paragraph (d), the Board of Managers may remove any member of<br \/>\nthe Executive Committee at any time. The Executive Committee shall meet as<br \/>\nnecessary. Members of the Executive Committee may participate in meetings of the<br \/>\nExecutive Committee in person, by proxy, or by telephonic conference call in<br \/>\nwhich all participants can hear each other.<\/p>\n<p>      (e) The Executive Committee shall have the power and authority to take all<br \/>\nactions delegated to it by the Board of Managers.<\/p>\n<p>      8.2. Other Investments. (a) Except as provided in Sections 8.2(b) and (c),<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nno Member may make directly or indirectly, and each Member shall cause its<br \/>\nAffiliates and Associates not to make, directly or indirectly, an investment in<br \/>\nany E-Healthcare Company, except through its interest in the Company in<br \/>\naccordance with the terms of this Agreement, unless and until (i) each Member<br \/>\nhas contributed its respective Base Commitment to the Company, (ii) the<br \/>\nexpiration of the Investment Period or (iii) Lofberg ceases to be the Chief<br \/>\nExecutive Officer of the Company.<\/p>\n<p>           (b) Notwithstanding anything to the contrary in this Agreement, if<br \/>\nMerck proposes an investment in an E-Healthcare Company to the Company<br \/>\n(including a follow-on investment in a Portfolio Company) and Lofberg rejects<br \/>\nsuch proposal or does not approve such proposal within 21 days of its submission<br \/>\nto the Investment Committee in the case of an initial investment and 10 Business<br \/>\nDays of its submission to the Investment Committee in the case of a follow-on<br \/>\ninvestment (such submission to include such information in the possession of<br \/>\nMerck that it reasonably believes is necessary to enable the Investment<br \/>\nCommittee to make an informed investment decision), Merck or any of its<br \/>\nAffiliates or Associates (other than the Company) shall be permitted to make an<br \/>\ninvestment in such E-Healthcare Company on terms no more favorable than those<br \/>\nrejected by Lofberg.<\/p>\n<p>           (c) Notwithstanding anything to the contrary in this Agreement, Merck<br \/>\nand any of its Affiliates and Associates may make any investment in an<br \/>\nE-Healthcare Company if such investment together with all previous investments<br \/>\nin such E-Healthcare Company, in the aggregate, would exceed $20 million or if<br \/>\nit would result in Merck, together with its Affiliates and Associates<br \/>\nbeneficially owning in excess of 20% <\/p>\n<p>                                     -14-<\/p>\n<p>of the outstanding equity of such E-Healthcare Company, provided, however, that,<br \/>\n                                                        &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nexcept as provided by paragraph (b), this paragraph shall not permit Merck to<br \/>\ninvest in an existing Portfolio Company other than through the Company, unless,<br \/>\nupon consummation of such investment, the Company, Merck and all Affiliates and<br \/>\nAssociates of Merck would, in the aggregate, beneficially own equity interests<br \/>\nrepresenting 50% or more of the voting equity interests of such Portfolio<br \/>\nCompany.<\/p>\n<p>           (d) If Merck or any of its Affiliates or Associates (other than the<br \/>\nCompany) enters into a binding agreement to make a Control Acquisition (a<br \/>\n&#8220;Control Acquisition Agreement&#8221;), Merck shall, on its own behalf or on behalf of<br \/>\n &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nits Affiliate or Associate that is a party to the Control Acquisition Agreement,<br \/>\nhave the absolute right, for a period of 10 Business Days from the date of the<br \/>\nControl Acquisition Agreement (and, if applicable, so long as the majority of<br \/>\nthe Other Investors has not previously delivered a Put Notice as defined in<br \/>\nparagraph (e) below), by giving written notice to the Carry Members (a &#8220;Call<br \/>\n                                                                        &#8212;-<br \/>\nNotice&#8221;), to buy all, but not less than all, of the Portfolio Investments in the<br \/>\n&#8212;&#8212;<br \/>\nrelevant Portfolio Company held by the Company (the &#8220;Control Acquisition<br \/>\n                                                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nInterest&#8221;).<br \/>\n&#8212;&#8212;&#8211;<\/p>\n<p>           (e) If Merck or any of its Affiliates or Associates (other than the<br \/>\nCompany) makes a Control Acquisition, the majority of the Other Investors shall<br \/>\nhave an absolute right, for a period of 10 Business Days from the date of the<br \/>\nControl Acquisition and so long as Merck has not previously delivered a Call<br \/>\nNotice, by giving written notice to Merck (the &#8220;Put Notice&#8221;), to cause the<br \/>\n                                                &#8212;&#8212;&#8212;-<br \/>\nCompany to sell all, but not less than all, of the Control Acquisition Interest<br \/>\nto Merck or such Affiliate or Associate.<\/p>\n<p>           (f) Upon delivery of a Call Notice pursuant to Section 8.2(d) or a<br \/>\nPut Notice pursuant to Section 8.2(e), Merck or its Affiliate or Associate will<br \/>\nbe obligated to purchase from the Company, and the Company will be obligated to<br \/>\nsell to Merck or its Affiliate or Associate, all, but not less than all, of the<br \/>\nControl Acquisition Interest in exchange for payment of the Control Acquisition<br \/>\nPrice.<\/p>\n<p>           (g) The consummation of the purchase of the Control Acquisition<br \/>\nInterest pursuant to this section 8.2 will take place (i) in the case of a<br \/>\npurchase resulting from the delivery of a Call Notice, to the extent reasonably<br \/>\npracticable simultaneously with the closing of the relevant Control Acquisition,<br \/>\nand (ii) in the case of a purchase resulting from the delivery of a Put Notice,<br \/>\non a date mutually agreeable to the parties but in any event not later than 30<br \/>\nBusiness Days following the date of the Put Notice (in each case, the &#8220;Purchase<br \/>\n                                                                       &#8212;&#8212;&#8211;<br \/>\nDate&#8221;). On the Purchase Date, Merck or its Affiliate or Associate shall pay to<br \/>\n&#8212;-<br \/>\nthe Company the Control Acquisition Price against delivery to Merck or its<br \/>\nAffiliate or Associate of the Control Acquisition Interest, free and clear of<br \/>\nall encumbrances, but without representation or warranty by the Company other<br \/>\nthan as to title. The consummation of the sale and purchase under this Section<br \/>\n8.2(g) will be a Sale of a Portfolio Investment for the purposes of this<br \/>\nAgreement.<\/p>\n<p>                                     -15-<\/p>\n<p>           (h) Merck and its Affiliates or Associates shall be free to make any<br \/>\nand all investments not expressly required by this Agreement to be made in the<br \/>\nCompany outside the Company; provided, however, that Merck and its Affiliates<br \/>\nand Associates (other than the Company) shall not, following termination of the<br \/>\nInvestment Period, make a follow-on investment in which the Company has an<br \/>\nexisting Portfolio Investment unless and until it shall have given each Other<br \/>\nInvestor Member, by written notice to such Other Investor Member specifying the<br \/>\nPortfolio Company to which such follow-in investment relates and the terms and<br \/>\nconditions of such follow-on investment (a &#8220;Co-Investment Notice&#8221;), the right to<br \/>\nco-invest, on the same terms and conditions as Merck or its Affiliate or<br \/>\nAssociate, an amount equal to (but not less than) the amount such Other Investor<br \/>\nMember would have been required to contribute to the Company in respect of the<br \/>\nacquisition of such follow-on investment, assuming (1) it were then being made<br \/>\nby the Company, (2) the Investment Period had not ended and (3) the $10 million<br \/>\nlimit set forth in clause (iii) of the last sentence of Section 5.1 did not<br \/>\napply (the &#8220;Co-investment Right&#8221;). The Co-investment Right of an Other<br \/>\nInvestment Member in respect of a follow-up investment shall expire if such<br \/>\nOther Investment Member shall not, within 10 Business Days of the delivery of<br \/>\nthe Co-Investment Notice to such Member, deliver to Merck written notice<br \/>\nirrevocably electing to exercise such Co-investment Right. The Other Investor<br \/>\nMembers shall not have any Carry Interest in follow-on investments to which the<br \/>\nCo-Investment Right pertains.<\/p>\n<p>      8.3 Certain Other Fees. (a) Each Carry Member covenants that if it or any<br \/>\n          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nof its Affiliates or Associates provides any services to, or enters into any<br \/>\ntransaction with, a Portfolio Company (or a Person in which the Company is<br \/>\nconsidering making a Portfolio Investment if such Person subsequently becomes a<br \/>\nPortfolio Company), in which such Carry Member (a &#8220;Benefiting Member&#8221;) or its<br \/>\nAffiliates or Associates receives securities, transaction fees, financing fees,<br \/>\ndirector fees, or any other type of fees or any other thing of value<br \/>\n(collectively, &#8220;Other Fees&#8221;), from such Portfolio Company, all such Other Fees<br \/>\nwill be deemed to be the property of the Company, will, except as provided in<br \/>\nparagraph (c), be promptly conveyed to the Company net of any taxes, if any,<br \/>\nassumed to be payable at the Applicable Tax Rate, for which such Benefiting<br \/>\nMember or its Affiliates or Associates are liable and, until so conveyed, will<br \/>\nbe held in trust for the benefit of the Company.<\/p>\n<p>      (b) Merck covenants that if it or any of its Affiliates or Associates<br \/>\nenters into a commercial arrangement with a Portfolio Company (or a Person in<br \/>\nwhich the Company is considering making a Portfolio Investment if such Person<br \/>\nsubsequently becomes a Portfolio Company), in which Merck or its Affiliates or<br \/>\nAssociates receives securities from such Portfolio Company as part of such<br \/>\ncommercial arrangement and not for cash (and excluding Warrants Acquired for<br \/>\nCash and securities acquired upon the cashless exercise of Warrants Acquired for<br \/>\nCash) (&#8220;Other Securities&#8221;), all such Other Securities will be deemed to be the<br \/>\n        &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nproperty of the Company, will, except as provided in paragraph (c), be promptly<br \/>\nconveyed to the Company net of any taxes, if any, assumed <\/p>\n<p>                                     -16-<\/p>\n<p>to be payable at the Applicable Tax Rate, for which Merck or its Affiliates or<br \/>\nAssociates are liable and, until so conveyed, will be held in trust for the<br \/>\nbenefit of the Company. The acquisition of Other Securities by Merck shall not<br \/>\nconstitute a Control Acquisition for purposes of Section 8.2 even if after<br \/>\ngiving effect thereto, the Company, Merck and Merck&#8217;s Affiliates and Associates<br \/>\nwould, in the aggregate, own more than 20% of the outstanding voting equity of a<br \/>\nPortfolio Company.<\/p>\n<p>      (c) Each Benefiting Member or Merck, as the case may be, that is required<br \/>\nby this Section 8.3 to transfer Other Fees or Other Securities to the Company<br \/>\n(the &#8220;Transferring Member&#8221;), shall use commercially reasonable efforts (at the<br \/>\n      &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nCompany&#8217;s expense) to obtain all necessary consents and approvals that may be<br \/>\nrequired in connection with the transfer of such Other Fees and Other Securities<br \/>\nto the Company (&#8220;Required Consents&#8221;). If a Required Consent is denied or if the<br \/>\n                 &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nTransferring Member has not, for any other reason transferred any Other Fees or<br \/>\nOther Securities to the Company as required by this Section 8.3, then the<br \/>\nBenefiting Member or Merck, as applicable, shall pay to the Company in cash<br \/>\nimmediately on receipt for distribution in accordance with Article 10 an amount<br \/>\nor amounts equal to all Net Sale Proceeds upon a Sale of such securities by such<br \/>\nBenefiting Member or Merck, as applicable, or their respective Affiliates or<br \/>\nAssociates net of any taxes, assumed to be payable at the Applicable Tax Rate,<br \/>\nfor which such Benefiting Member or Merck or Affiliates or Associates thereof,<br \/>\nas applicable, are liable.<\/p>\n<p>      (d) Notwithstanding anything to the contrary contained in this Agreement,<br \/>\nany contributions made to the Company pursuant to this Section 8.3 will not be<br \/>\ndeemed Capital Contributions of the Benefiting Member or increase the<br \/>\nAcquisition Cost or the Benefiting Member&#8217;s share of the Acquisition Cost of the<br \/>\nrelated Portfolio Investment. Except as provided in the immediately preceding<br \/>\nsentence, all Other Fees and Other Securities shall be deemed to be part of the<br \/>\nrelated Portfolio Investments for all purposes of this Agreement and shall be<br \/>\ndistributed to the Members to the extent contemplated by and in accordance with<br \/>\nArticle 10, except that, until transferred to the Company as required by this<br \/>\nSection 8.3, Other Fees and Other Securities (and their acquisition and<br \/>\ndisposition) shall not be subject to the provisions of Section 6.13 or 10.2(a),<br \/>\n(b) or (c).<\/p>\n<p>      8.4. MCV Budget. (a) At least 30 days but not more than 90 days prior to<br \/>\n           &#8212;&#8212;&#8212;-<br \/>\nthe beginning of each Fiscal Year (other than with respect to the 2001 Fiscal<br \/>\nYear), the Company will prepare and submit to the Board of Managers for its<br \/>\napproval the proposed budget for the following Fiscal Year, showing on a monthly<br \/>\nbasis anticipated Fees and Expenses for such Fiscal Year together with any other<br \/>\ninformation that the Board of Managers shall require) (the budget, as so<br \/>\napproved in accordance with Section 6.13 and this Section 8.4, the &#8220;MCV<br \/>\n                                                                    &#8212;<br \/>\nBudget&#8221;). The MCV Budget in respect of the 2001 Fiscal Year shall be prepared<br \/>\n&#8212;&#8212;<br \/>\nand submitted for approval as soon as reasonably practicable following the date<br \/>\nof this Agreement and in any event no later than December 11, 2000.<\/p>\n<p>                                     -17-<\/p>\n<p>      8.5. Administrative Staff. Merck shall make available to the Company the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nfull-time services of (i) up to two employees of Merck or an Affiliate of Merck,<br \/>\nas necessary, to act as financial analysts for the Company, and (ii) up to two<br \/>\nemployees of Merck or an Affiliate of Merck to support the Company as<br \/>\nadministrative staff. So long as he is Chief Executive Officer of the Company,<br \/>\nLofberg shall (i) with the consent of the employee and of the employee&#8217;s<br \/>\nemployer (the &#8220;Applicable Employer&#8221;), whose consent shall not be unreasonably<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nwithheld or delayed, be entitled to select the employees seconded to the Company<br \/>\npursuant to this Section 8.5, and (ii) be entitled to terminate the secondment<br \/>\nof any such employee. Notwithstanding anything in this Agreement to the<br \/>\ncontrary, (a) the Applicable Employer retains the right to terminate for Cause<br \/>\nthe employment of any employee seconded to the Company, and (b) any costs and<br \/>\nexpenses incurred by the Applicable Employer in connection with the employment<br \/>\nof seconded employees during the period such person&#8217;s services are used by the<br \/>\nCompany shall be deemed to be Carry Member Costs for purposes of this Agreement<br \/>\nunless otherwise excluded from the definition of Carry Member Costs.<\/p>\n<p>      8.6. Fees and Expenses; Carry Member Costs. The Company shall be<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nresponsible for all Fees and Expenses and Carry Member Costs from the end of the<br \/>\nExpenses Period and will reimburse Merck and its Affiliates for all such Carry<br \/>\nMember Costs incurred by Merck or any of its Affiliates upon receipt of an<br \/>\ninvoice from Merck specifying the nature and amount of such Carry Member Costs.<\/p>\n<p>                                    ARTICLE 9<\/p>\n<p>                            ACCOUNTS AND ALLOCATIONS<br \/>\n                            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      9.1. Capital Accounts.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>      (a) A separate Capital Account shall be established and maintained for<br \/>\neach Member in accordance with Reg. ss.1.704-1(b)(2)(iv). The initial balance of<br \/>\neach Member&#8217;s Capital Account shall be equal to the amount of cash and the Fair<br \/>\nMarket Value of any property (net of any liability secured by such property that<br \/>\nthe Company is considered to assume, or take subject to, under Section 752 of<br \/>\nthe Code) contributed by such Member as a Capital Contribution to the Company.<\/p>\n<p>      (b) The Capital Account of each Member shall be increased by any Net<br \/>\nProfits and gross income items allocated to such Member and any additional<br \/>\nCapital Contributions by such Member.<\/p>\n<p>      (c) The Capital Account of each Member shall be reduced by (i) the amount<br \/>\nof any distribution of cash or the Fair Market Value of any property (net of any<br \/>\nliability secured by such property that the Member is considered to assume or<br \/>\ntake subject to Section 752 of the Code) distributed to such Member pursuant to<br \/>\nArticle 10 in respect of the Member&#8217;s Capital Account (other than distributions<br \/>\ntreated as guaranteed <\/p>\n<p>                                     -18-<\/p>\n<p>payments within the meaning of Section 707(c) of the Code) when such<br \/>\ndistribution is made, and (ii) the Net Losses and items of deduction or expense<br \/>\nallocated to such Member including, without limitation, any &#8220;partner nonrecourse<br \/>\ndeductions&#8221; (as defined in Reg. ss. 1.704-2(i)) and any &#8220;nonrecourse deductions&#8221;<br \/>\n(as defined in Reg. ss. 1.704-2(b)) allocated to such Member.<\/p>\n<p>      (d) Except as otherwise provided in this Agreement, whenever it is<br \/>\nnecessary to determine the Capital Account of any Member, the Capital Account of<br \/>\nsuch Member shall be determined after giving effect to the allocations of Net<br \/>\nProfits, Net Losses and other items realized prior or concurrently to such time<br \/>\n(including, without limitation, any Net Profits and Net Losses attributable to<br \/>\nadjustments to Book Values with respect to any concurrent distribution), and all<br \/>\ncontributions and distributions made prior or concurrently to the time as of<br \/>\nwhich such determination is to be made.<\/p>\n<p>      (e) In the event that there is a negative balance in the Capital Account<br \/>\nof any Member, such Member shall not be obligated to make any additional Capital<br \/>\nContributions or otherwise be liable to restore the negative balance to zero.<\/p>\n<p>      9.2. Allocations.<br \/>\n           &#8212;&#8212;&#8212;&#8211;<\/p>\n<p>      (a) Allocation of Net Profits and Net Losses.<br \/>\n          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>                (i)   Net Losses. After giving effect to the special allocations<br \/>\n                      &#8212;&#8212;&#8212;-<br \/>\n      in clauses (b) through (e) hereof, Net Losses (and if necessary, items<br \/>\n      thereof) for any Fiscal Year (or period) shall be allocated among the<br \/>\n      Members so as to eliminate the differences between their respective<br \/>\n      Partially Adjusted Capital Account balances and Target Capital Account<br \/>\n      balances for such Fiscal Year (or other period).<\/p>\n<p>                (ii)  Net Profits. After giving effect to the special<br \/>\n                      &#8212;&#8212;&#8212;&#8211;<br \/>\n      allocations in clauses (b) through (e) hereof, Net Profits (and if<br \/>\n      necessary, items thereof) for any Fiscal Year (or period) shall be<br \/>\n      allocated among the Members so as to eliminate the differences between<br \/>\n      their respective Target Capital Accounts balances and Partially Adjusted<br \/>\n      Capital Account balances for such Fiscal Year (or other period).<\/p>\n<p>                (iii) Limitation on Allocations. Notwithstanding anything to the<br \/>\n                      &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n      contrary contained herein, Net Profits, Net Losses and items thereof<br \/>\n      arising with respect to a Portfolio Investment shall not be allocated to a<br \/>\n      Member who has not made a Capital Contribution with respect to such<br \/>\n      Portfolio Investment (unless such Member has a Carry Interest with respect<br \/>\n      to such Portfolio Investment).<\/p>\n<p>                (iv) Schedule C illustrates the intent of Section 9.2(a) by way<br \/>\n      of a <\/p>\n<p>                                     -19-<\/p>\n<p>      hypothetical example.<\/p>\n<p>      (b) Notwithstanding any other provision of this Agreement, (i) &#8220;partner<br \/>\nnonrecourse deductions&#8221; (as defined in Reg. ss. 1.704-2(i)), if any, of the<br \/>\nCompany shall be allocated to the Members that bear the economic risk of loss<br \/>\nwithin the meaning of Reg. ss. 1.704-2(i), and (ii) &#8220;nonrecourse deductions&#8221; (as<br \/>\ndefined in Reg. ss. 1.704-2(b)), if any, of the Company with respect to each<br \/>\nperiod as it relates to a particular Portfolio Investment shall be allocated<br \/>\namong the Members in proportion to their share of the Net Acquisition Cost of<br \/>\nsuch Portfolio Investment made by such Members, and to the extent that such<br \/>\nnonrecourse deductions do not relate to any particular Portfolio Investment, to<br \/>\nthe Members in accordance with the proportion of aggregate Capital Contributions<br \/>\nmade by each Member.<\/p>\n<p>      (c) This Agreement shall be deemed to include &#8220;qualified income offset,&#8221;<br \/>\n&#8220;minimum gain chargeback&#8221; and &#8220;partner nonrecourse debt minimum gain chargeback&#8221;<br \/>\nprovisions within the meaning of Regulations under Section 704(b) of the Code.<br \/>\nAccordingly, notwithstanding any other provision of this Agreement, items of<br \/>\nincome or gain shall be allocated to the Members on a priority basis to the<br \/>\nextent and in the manner required by such provisions.<\/p>\n<p>      (d) Subject to Sections 9.2(b), (c) and (e), if any items of income,<br \/>\nexpense or deduction are specially allocated pursuant to Section 9.2(b) or (c),<br \/>\nor the allocation of Net Loss or items of deduction or expense is limited by<br \/>\nSection 9.2(e), items of income, gain, deduction and expense, in subsequent<br \/>\nperiods, shall be specially allocated so that the net cumulative amount of all<br \/>\nitems allocated to each Member (taking into account any minimum gain or partner<br \/>\nnonrecourse debt minimum gain chargeback that would occur if the Company were to<br \/>\nliquidate) shall, to the extent possible, be equal to the amount that would have<br \/>\nbeen allocated to such Member without regard to Section 9.2(b), (c) or (e).<\/p>\n<p>      (e) Notwithstanding any other provisions of this Agreement, no allocation<br \/>\nof Net Loss or items of deduction or expense shall be made to any Member to the<br \/>\nextent that the effect of such allocation would be to cause the Member to have a<br \/>\nnegative balance in its Capital Account, after taking into account any<br \/>\nadjustments, allocations or distributions described in Reg. ss. 1.704-<br \/>\n1(b)(2)(ii)(d)(4), (5) or (6), in excess of the maximum amount of such negative<br \/>\nbalance such Member would be obligated (or deemed obligated under the<br \/>\nRegulations) to contribute to the Company upon liquidation.<\/p>\n<p>      9.3. Tax Allocations. (a) For tax purposes, all items of income, gain,<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nloss, or deduction shall be allocated to the Members in the same manner as they<br \/>\nare allocated for purposes of maintaining Capital Accounts; provided, however,<br \/>\n                                                            &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nthat (i) if the Fair Market Value of any property of the Company differs from<br \/>\nits adjusted basis for tax <\/p>\n<p>                                      -20-<\/p>\n<p>purposes, then items of income, gain, loss, deduction for tax purposes shall be<br \/>\nallocated among the Members in a manner that takes account of both the amount<br \/>\nand character of the variation between the adjusted basis of the property for<br \/>\ntax purposes and its Fair Market Value in the manner provided for under Section<br \/>\n704(c) of the Code using any method or methods determined by the Board of<br \/>\nManagers after reasonable consultation with Lofberg and (ii) the Board of<br \/>\nManagers may make such adjustments as it deems appropriate, in its discretion<br \/>\nafter reasonable consultation with Lofberg, to reflect the economic interests of<br \/>\nthe Members in the Company.<\/p>\n<p>      (b) Items of credit shall be allocated among the Members in the manner<br \/>\nprovided in Reg.ss. 1.704-1(b)(4)(ii).<\/p>\n<p>                                   ARTICLE 10<\/p>\n<p>                                  DISTRIBUTIONS<br \/>\n                                  &#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>      10.1. Distributions. (a) Subject to the provisions of this Article 10,<br \/>\n            &#8212;&#8212;&#8212;&#8212;-<br \/>\nAvailable Cash shall be distributed from time to time as the Board of Managers<br \/>\nshall determine but not less often than annually; provided, that Available Cash<br \/>\n                                                  &#8212;&#8212;&#8211;<br \/>\narising by reason of the sale by the Company of a Portfolio Investment or by<br \/>\nreason of Section 8.3 shall be distributed within 30 days after receipt thereof<br \/>\nby the Company in accordance with Section 10.1(b). Pending distribution, all<br \/>\nAvailable Cash shall be invested in Short-Term Investments. Subject to this<br \/>\nArticle 10, other Company property, less such amounts as the Board of Managers<br \/>\ndeems necessary to meet current or future Company costs or obligations, shall be<br \/>\ndistributed at such time or times as the Board of Managers deems appropriate,<br \/>\nsubject to the restrictions described herein.<\/p>\n<p>      (b) All Available Cash of the Company in respect of a Portfolio<br \/>\nInvestment, less, if the Portfolio Investment was Sold, expenses attributable to<br \/>\nsuch Sale (the &#8220;Proceeds&#8221; of such Portfolio Investment) shall be distributed as<br \/>\n                &#8212;&#8212;&#8211;<br \/>\nfollows:<\/p>\n<p>                (i)   first, 100% to Merck until it has received an amount equal<br \/>\n                      &#8212;&#8211;<br \/>\n      to all Attributable Carry Member Costs and Attributable Fees and Expenses<br \/>\n      of all Portfolio Investments that have been Sold;<\/p>\n<p>                (ii)  second, 100% to the Contributing Members in proportion to<br \/>\n                      &#8212;&#8212;<br \/>\n      their share of the Acquisition Cost of that Portfolio Investment until<br \/>\n      they have received an amount equal to the Net Acquisition Cost of the<br \/>\n      Portfolio Investment; and<\/p>\n<p>                (iii) thereafter, subject to Section 10.1(c), all remaining<br \/>\n                      &#8212;&#8212;&#8212;-<br \/>\n      Proceeds to the Contributing Members in proportion to their share of the<br \/>\n      Acquisition <\/p>\n<p>                                     -21-<\/p>\n<p>      Cost of such Portfolio Investment; provided, however, that<br \/>\n                                         &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\n      Merck&#8217;s distribution pursuant to this Section 10.1(b)(iii) shall be<br \/>\n      reduced by an amount equal to each Carry Member&#8217;s Applicable Carried<br \/>\n      Interest in respect of such Portfolio Investment of Merck&#8217;s share of the<br \/>\n      Proceeds distributable pursuant to this Section 10.1(b)(iii) (before<br \/>\n      giving effect to this proviso) less the amount, if any, of such Carry<br \/>\n                                     &#8212;-<br \/>\n      Member&#8217;s Negative Carry Balance and such amount, if any, will be<br \/>\n      distributed to such Carry Member.<\/p>\n<p>      (c) Notwithstanding the foregoing, if a distribution in respect of a<br \/>\nPortfolio Investment is made and a Carry Member&#8217;s Applicable Carried Interest in<br \/>\nrespect of that Portfolio Investment later increases in accordance with the<br \/>\ndefinition of Applicable Carried Interest, the Company shall promptly make an<br \/>\nadditional distribution to such Carry Member and\/or Merck shall pay over to such<br \/>\nCarry Member an amount (or securities in the case of an in kind distribution)<br \/>\nequal to the difference between the distribution such Carry Member would have<br \/>\nbeen entitled to receive at the higher Applicable Carried Interest and the<br \/>\ndistribution previously made. In connection with any distribution, the Company<br \/>\nshall be entitled to withhold and set aside such reserves as the Board of<br \/>\nManagers may determine may be required to fund such subsequent retroactive<br \/>\nadjustments.<\/p>\n<p>      (d) At the time final distributions are made upon the dissolution of the<br \/>\nCompany or upon a Carry Member ceasing to be a Carry Member in respect of all<br \/>\nPortfolio Investments, any amounts required to be contributed by such Member to<br \/>\nthe Company pursuant to Section 12.4, may be off set by the Company against any<br \/>\ndistributions required to be made by the Company to a Member pursuant to Section<br \/>\n10.1(b).<\/p>\n<p>      (e) Notwithstanding the foregoing, if the aggregate distributions to a<br \/>\nMember during a Fiscal Year, and the three months following such Fiscal Year,<br \/>\nwould not otherwise equal or exceed the Tax Liability Amount, then on or prior<br \/>\nto the Tax Payment Date, the Company shall distribute the amount of such<br \/>\ndeficiency to such Member (the &#8220;Tax Distribution&#8221;). Tax Distributions shall be<br \/>\n                                &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\ntreated as advances on future distributions that would otherwise be made to such<br \/>\nMember, so that future amounts otherwise distributable to a Member shall be<br \/>\nreduced by the amount of any Tax Distribution. At the election of the Board of<br \/>\nManagers, in reasonable consultation with Lofberg, Tax Distributions may be made<br \/>\nin quarterly installments during the Fiscal Year.<\/p>\n<p>      (f) Schedule C, illustrates the intent of Section 10.1(b) by way of a<br \/>\nhypothetical example.<\/p>\n<p>      10.2. Certain Other Distributions.<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      (a) If, at a time when Lofberg is Chief Executive Officer of the Company<br \/>\nor, thereafter, if Lofberg&#8217;s employment with Merck or an Affiliate of Merck to<\/p>\n<p>                                      -22-<\/p>\n<p>act as Chief Executive Officer of the Company is terminated (i) at any time<br \/>\nwithout Cause or (ii) for any reason after the second anniversary of this<br \/>\nAgreement, a Portfolio Company closes a Qualified IPO and Lofberg recommends to<br \/>\nthe Board of Managers no later than 10 Business Days prior to the commencement<br \/>\nof the roadshow for such Qualified IPO selling 100% of the Company&#8217;s interest in<br \/>\nsuch Portfolio Company in such Qualified IPO and the Board of Managers rejects<br \/>\nsuch recommendation, then the Company shall distribute 100% of the Portfolio<br \/>\nInvestment in the Portfolio Company to the Members in accordance with Section<br \/>\n10.1(b), as soon as practicable following the date of such Qualified IPO (or if<br \/>\nrequested by the underwriters of such Qualified IPO, following the date the<br \/>\nCompany is no longer subject to any lock up restrictions), on the assumption<br \/>\nthat such Portfolio Investments were sold for the issue price under the<br \/>\nQualified IPO.<\/p>\n<p>      (b) If, at a time when Lofberg is Chief Executive Officer of the Company<br \/>\nor, thereafter, if Lofberg&#8217;s employment with Merck or an Affiliate of Merck to<br \/>\nact as Chief Executive Officer of the Company is terminated (i) at any time<br \/>\nwithout Cause or (ii) for any reason after the second anniversary of this<br \/>\nAgreement, Lofberg recommends selling 100% of the Company&#8217;s Portfolio Investment<br \/>\nat the time when the entirety of such Portfolio Investment constitutes<br \/>\nMarketable Securities (a &#8220;Divestment Proposal&#8221;) and the Board of Managers<br \/>\n                          &#8212;&#8212;&#8212;- &#8212;&#8212;&#8211;<br \/>\nrejects such Divestment Proposal, then<\/p>\n<p>                (A) if the Portfolio Company is a Qualifying Issuer, the Company<br \/>\n      shall distribute the securities of such Portfolio Company to the Members<br \/>\n      in accordance with Section 10.1(b) within 10 Business Days following the<br \/>\n      determination by the Board of Managers of the Fair Market Value of such<br \/>\n      Portfolio Investments as of the Applicable Valuation Date, on the<br \/>\n      assumption that such Portfolio Investment was sold for the Fair Market<br \/>\n      Value determined by the Board of Managers as of the Applicable Valuation<br \/>\n      Date; and<\/p>\n<p>                (B) in all other cases, the Company shall promptly distribute to<br \/>\n      the Other Investor Members their pro rata share of the securities of such<br \/>\n      Portfolio Company (net of securities having a Fair Market Value equal to<br \/>\n      their share of Attributable Carry Member Costs and Attributable Fees and<br \/>\n      Expenses, assuming 100% of the Portfolio Investment was distributed in<br \/>\n      accordance with clause (A) above) and following such distribution the<br \/>\n      Other Investor Members shall have no further interest (other than as Carry<br \/>\n      Members) in the portion of the Portfolio Investment retained by the<br \/>\n      Company.<\/p>\n<p>      (c) If, at a time when Lofberg is Chief Executive Officer of the Company,<br \/>\nLofberg recommends to the Board of Managers approval of a Bona Fide Third Party<br \/>\nOffer setting forth the price and other material terms of such Bona Fide Third<br \/>\nParty <\/p>\n<p>                                      -23-<\/p>\n<p>Offer and the Board of Managers rejects such Bona Fide Third Party Offer,<br \/>\nthen, at the written request of Lofberg delivered to the Board of Managers<br \/>\nwithin 10 Business Days of such rejection, the Members shall be entitled to<br \/>\nreceive distributions in respect of their Interests in accordance with Section<br \/>\n10.1(b), at the election of the Board of Managers, either in cash or by<br \/>\ndistribution in kind within 30 Business Days following the demand by Lofberg, on<br \/>\nthe assumption that such Portfolio Investment were sold for the price set forth<br \/>\nin the Bona Fide Third Party Offer. Notwithstanding anything to the contrary, if<br \/>\na distribution is made pursuant to this Section 10.2(c), the Carry Members will<br \/>\nnot, except to the extent provided in Section 10.1(c) be entitled to any further<br \/>\ndistributions made by the Company pursuant to Section 10.1(b), or otherwise in<br \/>\nrespect of such Portfolio Investment (other than as Investor Members) and their<br \/>\nApplicable Carried Interest in respect thereof after the application of this<br \/>\nSection 10.2(c) shall be deemed to be zero.<\/p>\n<p>      (d) If a Portfolio Investment has not been liquidated or distributed prior<br \/>\nto the tenth anniversary of this Agreement, the Board of Managers shall either<br \/>\n(i) cause such Portfolio Investment to be liquidated within 90 days or (ii)<br \/>\nvalued in accordance with Section 10.5 as of the Applicable Valuation Date. The<br \/>\nMembers shall be entitled to receive distributions in respect of their Interests<br \/>\n(A) in accordance with Section 10.1(b) in cash upon the final liquidation of all<br \/>\nPortfolio Investments being liquidated in the case of clause (i), and (B) at the<br \/>\nelection of the Board of Managers either in cash or by distribution in kind<br \/>\nwithin 10 Business Days following delivery by the Third Party Valuation Firm of<br \/>\nits report calculating the Fair Market Value of the remaining Portfolio<br \/>\nInvestments, on the assumption in such case that each unliquidated Portfolio<br \/>\nInvestment were sold for the Fair Market Value set forth in the valuation report<br \/>\n(the &#8220;Valuation Report&#8221;) in the case of clause (ii). Notwithstanding anything to<br \/>\n      &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nthe contrary, if a distribution is made pursuant to this Section 10.2(d), the<br \/>\nCarry Members will not be entitled to any further distributions made by the<br \/>\nCompany pursuant to Section 10.1(b) or otherwise in respect of such Portfolio<br \/>\nInvestment (other than as Investor Members) and their Applicable Carried<br \/>\nInterest in respect thereof after the application of this Section 10.2(d) shall<br \/>\nbe deemed to be zero.<\/p>\n<p>      10.3 Distributions in Kind. (a) The Board of Managers shall have<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nauthority, but, except as required by Section 10.2, shall not be required to<br \/>\ndistribute in kind any non-cash assets held by the Company.<\/p>\n<p>      (b) In the event of any distribution in kind, the value of the assets<br \/>\ndistributed shall be determined as of the Applicable Valuation Date in<br \/>\naccordance with Section 10.5 hereof. If the Carry Members will be entitled to<br \/>\nreceive a distribution in respect of their Applicable Carried Interests pursuant<br \/>\nto Section 10.2(d), the Fair Market Value of the assets to be distributed will<br \/>\nbe calculated by a Third Party Valuation Firm in accordance with the methodology<br \/>\nset forth in Section 10.5. A &#8220;Third Party Valuation Firm&#8221; shall mean any<br \/>\n                              &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nindependent nationally recognized investment banking firm, accounting firm or<br \/>\nappraisal firm selected by the Board of Managers and approved by<\/p>\n<p>                                      -24-<\/p>\n<p>Lofberg, such approval not to be unreasonably withheld or delayed. The Company<br \/>\nshall bear all of the expenses of the Third Party Valuation Firm retained by the<br \/>\nCompany.<\/p>\n<p>      (c) Except as required by Section 10.2, no determination by the Board of<br \/>\nManagers to obtain a valuation from a Third Party Valuation Firm in<br \/>\ncontemplation of an in-kind distribution shall obligate the Company to make any<br \/>\nsuch in-kind distribution.<\/p>\n<p>      (d) Investments distributed in kind pursuant to this Agreement shall be<br \/>\ndistributed, to the extent reasonably practicable, pro rata to the Members<br \/>\nentitled thereto and shall be subject to such conditions and restrictions as are<br \/>\nrequired by applicable law or any contractual obligation or as were previously<br \/>\nimposed on the Company.<\/p>\n<p>      10.4. Withholding Requirements. (a) Notwithstanding any other provision of<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthis Agreement, the Board of Managers is authorized to take any action that it<br \/>\ndetermines to be necessary or appropriate to cause the Company to comply with<br \/>\nany withholding requirements imposed under Section 1446 or any other provision<br \/>\nof the Code or state, local or foreign law.<\/p>\n<p>      (b) If the Code or any state, local or foreign law requires that the<br \/>\nCompany remit to the Internal Revenue Service (the &#8220;IRS&#8221;) or any other taxing<br \/>\n                                                    &#8212;<br \/>\nauthority any withholding tax with respect to, or for the account of, any Member<br \/>\n(in its capacity as a Member), the Board of Managers shall provide notice to<br \/>\nsuch Member of such obligation and such Member shall have the opportunity to<br \/>\nmake such payment on its own behalf. If such Member fails, or is not otherwise<br \/>\nable, to make such payment on its own behalf, the Company shall so remit to the<br \/>\nIRS or other taxing authority the full required amount of such withholding tax.<br \/>\nAny amount so remitted shall be credited against any distributions that would<br \/>\notherwise be made to such Member during such period or thereafter and any excess<br \/>\nof the amount so remitted over amounts so credited against distributions shall<br \/>\nbe treated as a recourse demand loan from the Company to the Member. For so long<br \/>\nas the Company is not dissolved and the Member remains a Member, unless<br \/>\notherwise paid, such loan shall be payable by credit against the first amounts<br \/>\nthat would otherwise be distributed to such Member (with any such payment being<br \/>\nallocated first to accrued and unpaid interest through the date of such payment)<br \/>\nbut may be prepaid in Cash by the Member, in whole or any part, at any time.<\/p>\n<p>      10.5. Valuations. To the extent the assets of the Company, or any portion<br \/>\n            &#8212;&#8212;&#8212;-<br \/>\nthereof, are required to be valued for any purpose, including without limitation<br \/>\nthe calculation of distributions in respect of the Applicable Carried Interests,<br \/>\nsuch valuation shall be made by the Third Party Valuation Firm in the case of<br \/>\nSections 10.2(d) and 12.3(c) and in all other cases by the Board of Managers in<br \/>\naccordance with the following:<\/p>\n<p>      (a) In determining the Fair Market Value on a given date of<br \/>\npublicly-traded securities for which market quotations are readily available (i)<br \/>\nany securities traded on a national securities exchange shall be valued at the<br \/>\naverage of the last trade <\/p>\n<p>                                      -25-<\/p>\n<p>prices for the twenty Business Days prior to the valuation date on which trading<br \/>\nin such securities actually occurred on the exchange where they are primarily<br \/>\ntraded or, if the securities are not traded on such valuation date, then for the<br \/>\ntwenty Business Days prior to the immediately preceding date on which such<br \/>\nsecurities were traded on which trading in such securities actually occurred,<br \/>\nand (ii) any securities traded in the over-the-counter market shall be valued at<br \/>\nthe average of the closing bid prices last quoted for the twenty Business Day<br \/>\nperiod prior to the valuation date by NASDAQ or, if not quoted by NASDAQ, at the<br \/>\naverage last quote prices for the twenty Business Days prior to such valuation<br \/>\ndate on which trading in such securities actually occurred as quoted in a<br \/>\nrecognized list for over-the-counter securities or, if the securities are not<br \/>\nquoted on such valuation date (but are actively quoted in such recognized list),<br \/>\nthen for the twenty Business Days prior to the immediately preceding date on<br \/>\nwhich such securities were quoted on which trading in such securities actually<br \/>\noccurred; provided, that in the case of any publicly-traded securities, the<br \/>\n          &#8212;&#8212;&#8211;<br \/>\ndetermination of Fair Market Value shall be adjusted downward to the extent that<br \/>\nthe Board of Managers or the Third Party Valuation Firm, as the case may be,<br \/>\nreasonably determines trading restrictions, block positions, thin trading or<br \/>\nother similar matters would materially adversely affect the realizable value of<br \/>\nsuch securities.<\/p>\n<p>      (b) The Fair Market Value of all other securities or other assets of the<br \/>\nCompany shall be reasonably determined by the Board of Managers or the Third<br \/>\nParty Valuation Firm, as the case may be, acting in good faith based on, among<br \/>\nother things, public market comparables, private market transactions,<br \/>\nindependent appraisals and discounted cash flow analyses.<\/p>\n<p>      (c) Liabilities shall be determined based upon GAAP by the Board of<br \/>\nManagers or the Third Party Valuation Firm, in consultation with the Board of<br \/>\nManagers and the Carry Members. The Board of Managers or the Third Party<br \/>\nValuation Firm, in consultation with the Board of Managers, as the case may be,<br \/>\nmay in its discretion provide reserves for estimated accrued expenses,<br \/>\nliabilities or contingencies, (including for the purpose specified in Section<br \/>\n10.1(c)) even if such reserves are not required by GAAP. If such reserves are<br \/>\nlater reversed, the amounts released shall be distributed to the Member or<br \/>\nMembers who would have been entitled to receive distributions of such amounts if<br \/>\nthe reversed portion of the reserve had not been established.<\/p>\n<p>                                   ARTICLE 11<\/p>\n<p>                        TRANSFER OF MEMBERSHIP INTERESTS<br \/>\n                        &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>      11.1. Transfers. (a) Subject to Section 11.1(b) and (c), no Member may<br \/>\n            &#8212;&#8212;&#8212;<br \/>\nsell, transfer, assign, pledge, hypothecate or otherwise dispose of (&#8220;Transfer&#8221;)<br \/>\nall or any part of its Membership Interests in the Company (including, without<br \/>\nlimitation, its right to <\/p>\n<p>                                      -26-<\/p>\n<p>receive a share of profits, losses and other allocations and distributions of<br \/>\nthe Company). Any purported Transfer of any interest in the Company in violation<br \/>\nof this Article 11 shall be null and void.<\/p>\n<p>      (b) Notwithstanding the provisions of Section 11.1(a), Merck shall be<br \/>\npermitted to Transfer its interests in the Company to any direct or indirect<br \/>\nwholly owned subsidiary of Merck &amp; Co., Inc., provided that such transferee has<br \/>\nagreed in writing with the Company to be bound by the provisions of this<br \/>\nAgreement as a Member.<\/p>\n<p>      (c) Notwithstanding the provisions of Section 11.1(a), each Other Investor<br \/>\nMember and Carry Member shall be permitted to grant participations in such<br \/>\nMember&#8217;s Membership Interests to his or her heirs or to a Family Trust for<br \/>\nestate planning purposes, but no such participant shall have any rights as a<br \/>\nMember or any consent rights under this Agreement.<\/p>\n<p>      11.2. Ownership of Membership Interests. The Company and the Board of<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nManagers shall be entitled to treat the record owner of any Membership Interests<br \/>\nas the absolute owner thereof in all respects until such time as a written<br \/>\ninstrument evidencing the Transfer of such Membership Interests has been<br \/>\nreceived by the Board of Managers and recorded on the books of the Company.<\/p>\n<p>                                   ARTICLE 12<\/p>\n<p>                     WITHDRAWAL; DISSOLUTION AND LIQUIDATION<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>      12.1. Withdrawal of Members. (a) Except as expressly provided for in<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nArticle 11, no Member may withdraw from the Company.<\/p>\n<p>      (b) A Member shall be deemed to have withdrawn from the Company upon an<br \/>\nEvent of Bankruptcy of such Member or any dissolution or liquidation of such<br \/>\nMember.<\/p>\n<p>      12.2. Events of Dissolution. The Company shall be dissolved upon the<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nearliest to occur of the following: (a) an Event of Bankruptcy of the Company;<br \/>\n(b) at the election of Merck if Lofberg shall cease to be the Chief Executive<br \/>\nOfficer of the Company or (c) the unanimous approval of the Investor Members to<br \/>\ndissolve the Company for any reason, including without limitation following the<br \/>\ndisposition of all Portfolio Investments.<\/p>\n<p>      12.3. Liquidation. If the Company is dissolved pursuant to Section 12.2,<br \/>\n            &#8212;&#8212;&#8212;&#8211;<br \/>\nthe Board of Managers (or any liquidating trustee appointed by the Board of<br \/>\nManagers or, in the event of a dissolution pursuant to Section 12.2(b), a<br \/>\nliquidating trustee appointed by Merck) shall (i) promptly file any notice,<br \/>\npublish any advertisement or take any other<\/p>\n<p>                                      -27-<\/p>\n<p>action required under applicable law to effect such dissolution, (ii) commence<br \/>\nto wind up the affairs of the Company and liquidate the assets of the Company<br \/>\nand (iii) apply and distribute the proceeds of such liquidation and any<br \/>\nundistributed cash no later than the end of the Fiscal Year following the Fiscal<br \/>\nYear in which such liquidation occurs in accordance with the terms hereof and in<br \/>\nthe following order of priority:<\/p>\n<p>      (a) First, to pay and discharge, or make provisions or establish reserves<br \/>\nfor, the claims of all creditors of the Company and to pay the expenses of<br \/>\nliquidation;<\/p>\n<p>      (b) Second, to establish such reserves as the Board of Managers or<br \/>\nliquidating trustee deems reasonably necessary for any contingent or unforeseen<br \/>\nliabilities or obligations of the Company; such reserve may be paid over by the<br \/>\nBoard of Managers or liquidating trustee to any attorney-at-law, or other party<br \/>\nacceptable to the Board of Managers or liquidating trustee, as escrow agent to<br \/>\nbe held for disbursement in payment of any such liabilities or obligations and,<br \/>\nat the expiration of such period as shall be deemed advisable by the Board of<br \/>\nManagers or liquidating trustee, for distribution of the balance in the manner<br \/>\nhereinafter provided in this Section 12.3; and<\/p>\n<p>      (c) Third, to make distributions to the Members in accordance with Section<br \/>\n10.1(b) (including, without limitation, applying the valuation methodology set<br \/>\nout in Section 10.5 in relation to distributions in kind, if any).<\/p>\n<p>      12.4. Return of Excess Distributions to Investor Members. If, at the time<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nfinal distributions are made upon the dissolution of the Company or upon a Carry<br \/>\nMember ceasing to have an Applicable Carried Interest in any outstanding<br \/>\nPortfolio Investments, after giving effect to all distributions to that Carry<br \/>\nMember calculated pursuant to Sections 10.1(b), 10.1(c) and 12.3, but before<br \/>\ngiving effect to this Section 12.4, such Carry Member will have received an<br \/>\nExcess Carry Amount, such Carry Member shall contribute to the Company, without<br \/>\ninterest, for distribution to Merck, an amount that equals the Excess Carry<br \/>\nAmount, reduced by the amount of federal, state, local and foreign tax<br \/>\nobligations borne by such Carry Member with respect to the Excess Carry Amount<br \/>\nas reasonably determined by such Carry Member (it being acknowledged and agreed<br \/>\nthat in making such determination such Carry Member shall assume that such<br \/>\namounts were earned by an individual paying income taxes at the Carry Member&#8217;s<br \/>\nApplicable Tax Rate), and increased by the actual federal, state, local and<br \/>\nforeign tax benefits realized by such Carry Member or its beneficial owners with<br \/>\nrespect to the repayment of any amount pursuant to this Section 12.4 as<br \/>\nreasonably determined by such Carry Member (it being acknowledged and agreed<br \/>\nthat in making such determination such Carry Member shall (i) assume that such<br \/>\namounts were paid by an individual paying income taxes at the Carry Member&#8217;s<br \/>\nApplicable Tax Rate, (ii) shall include any tax benefits realized by such Carry<br \/>\nMember in connection with receiving a reduced distribution pursuant to Section<br \/>\n10.1(d)) and (iii) shall only be deemed actually used after all other applicable<br \/>\ntax benefits that could have been used by such Carry Member have <\/p>\n<p>                                      -28-<\/p>\n<p>been deemed to be used; provided, however, that for the purposes of computing<br \/>\nsuch benefits, (a) any securities received by the Carry Member as a distribution<br \/>\nfrom the Company and held by such Carry Member shall be marked to market, and<br \/>\n(b) the gain or loss, as the case may be, with respect to such securities, shall<br \/>\nbe taken into account in determining the tax benefits realized by such Carry<br \/>\nMember as if such securities had been sold in fully taxable transactions.<\/p>\n<p>                                  ARTICLE 13<\/p>\n<p>                TAX MATTERS; CERTAIN REPRESENTATIONS OF MEMBERS<\/p>\n<p>          13.1. Designation of Tax Matters Member. Merck is hereby designated as<br \/>\n                &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthe &#8220;tax matters partner&#8221; (in such capacity, the &#8220;Tax Matters Member&#8221;) under<br \/>\n                                                  &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nSection 6231(a)(7) of the Code to manage, at the cost and expense of the<br \/>\nCompany, administrative tax proceedings conducted at the Company level by the<br \/>\nIRS with respect to Company matters. The Members are specifically directed and<br \/>\nauthorized to take whatever steps the Tax Matters Member, in its sole discretion<br \/>\ndeems necessary or desirable to perfect such designation, including, without<br \/>\nlimitation, filing any forms or documents with the IRS and taking such other<br \/>\naction as may from time to time be required under Regulations and cooperating<br \/>\nwith the Tax Matters Member in connection with any tax audit, investigation or<br \/>\nlitigation.<\/p>\n<p>          13.2. Tax Returns. The Tax Matters Member shall cause to be prepared<br \/>\n                &#8212;&#8212;&#8212;&#8211;<br \/>\nand filed, after reasonable consultation with Lofberg and at the cost and<br \/>\nexpense of the Company, all necessary Company tax returns, and the Members (and<br \/>\ntheir Affiliates) shall prepare their tax returns consistently with such Company<br \/>\ntax returns.<\/p>\n<p>          13.3. Taxable Year. The taxable year of the Company shall be the<br \/>\n                &#8212;&#8212;&#8212;&#8212;<br \/>\ncalendar year or such other year as may be reasonably determined by the Board of<br \/>\nManagers.<\/p>\n<p>          13.4. Tax Elections. All tax elections required or permitted to be<br \/>\n                &#8212;&#8212;&#8212;&#8212;-<br \/>\nmade under the Code and any applicable state, local or foreign tax law shall be<br \/>\nmade in the discretion of the Tax Matters Member after reasonable consultation<br \/>\nwith Lofberg, and any decision with respect to the treatment of Company<br \/>\ntransactions on the Company&#8217;s federal, state, local or foreign tax returns shall<br \/>\nbe made in such manner as may be approved by the Tax Matters Member after<br \/>\nreasonable consultation with Lofberg. Each of the Carry Members shall file a<br \/>\ntimely election in accordance with the rules set forth in Reg. (S)1.83-2,<br \/>\nwith respect to his or her receipt of the Carry Interest.<\/p>\n<p>          13.5. Certain Representations of Members. (a) Each Member, severally<br \/>\n                &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nand not jointly, as to itself only, hereby represents, warrants and acknowledges<br \/>\nto the Company and the other Members as follows:<\/p>\n<p>                                     -29-<\/p>\n<p>                    (i)   Such Member has full power and authority to execute<br \/>\n               and deliver this Agreement and to carry out its obligations<br \/>\n               hereunder in accordance with the terms and provisions hereof. The<br \/>\n               execution, delivery and performance of this Agreement and the<br \/>\n               consummation of the transactions contemplated hereby have been<br \/>\n               duly authorized by all requisite action, corporate or otherwise,<br \/>\n               on the part of such Member.<\/p>\n<p>                    (ii)  Such Member is a &#8220;United States person&#8221; within the<br \/>\n               meaning of Section 7701(a)(30) of the Code.<\/p>\n<p>                    (iii) Such Member is acquiring its Membership Interests<br \/>\n               solely for investment, for such Member&#8217;s own account and not with<br \/>\n               a view to, or for resale in connection with, the distribution or<br \/>\n               other disposition thereof.<\/p>\n<p>                    (iv)  Such Member has not pledged, hypothecated or<br \/>\n               encumbered his or her Membership Interest or entered into any<br \/>\n               agreement to do so.<\/p>\n<p>               (b)  Each Member acknowledges that its Membership Interests may<br \/>\nbe construed as &#8220;securities&#8221; for purposes of federal, state or local securities<br \/>\nlaws or regulations. Each Member further acknowledges and represents that it has<br \/>\nbeen advised that the membership interests of the Company have not been<br \/>\nregistered under the Securities Act of 1933, as amended.<\/p>\n<p>               (c)  Each Member acknowledges and represents that it is<br \/>\nexperienced in evaluating companies such as the Company, is able to fend for<br \/>\nitself in the transactions contemplated by this Agreement, has such knowledge<br \/>\nand experience in financial and business matters as to be capable of evaluating<br \/>\nthe merits and risks of its investment, and has the ability to bear the economic<br \/>\nrisks of its investment. Each Member further represents that it has had access,<br \/>\nduring the course of the transactions and prior to its purchase of Membership<br \/>\nInterests, to all such information as it deemed necessary or appropriate (to the<br \/>\nextent the Company possessed such information or could acquire it without<br \/>\nunreasonable effort or expense) and that it has had, during the course of the<br \/>\ntransactions and prior to its purchase of Membership Interests, the opportunity<br \/>\nto ask questions of, and receive answers from, the Company concerning the terms<br \/>\nand conditions of the offering and to obtain additional information (to the<br \/>\nextent the Company possessed such information or could acquire it without<br \/>\nunreasonable effort or expense) necessary to verify the accuracy of any<br \/>\ninformation furnished to it or to which it had access.<\/p>\n<p>               (d)  Each Member acknowledges and represents that it understands<br \/>\nthat the Membership Interests may not be sold, transferred or otherwise disposed<br \/>\nof without registration under the 1933 Act or an exemption therefrom, and that<br \/>\nin the absence of an effective registration statement covering the Membership<br \/>\nInterests or an available<\/p>\n<p>                                     -30-<\/p>\n<p>exemption from registration under the 1933 Act, the Membership Interests must be<br \/>\nheld indefinitely.<\/p>\n<p>               (e)   Each Member acknowledges and represents that it understands<br \/>\nthat no public market now exists for any of the securities issued by the Company<br \/>\nand that there is no assurance that a public market will ever exist for the<br \/>\nMembership Interests.<\/p>\n<p>                                  ARTICLE 14<\/p>\n<p>                           BOOKS OF ACCOUNT; REPORTS<br \/>\n                           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;- <\/p>\n<p>               14.1. Books of Account. The Board of Managers shall keep, or<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\ncause to be kept, accurate and complete records and books of account of all<br \/>\ntransactions of the Company. The Company books and records shall be maintained<br \/>\nat the principal place of business of the Company and shall be available for<br \/>\ninspection and examination, for a proper purpose and at reasonable times during<br \/>\nusual business hours, by Members or their respective duly authorized<br \/>\nrepresentatives. Except as otherwise expressly provided in this Agreement, such<br \/>\ninformation shall not be disclosed to third parties and shall be used for<br \/>\nCompany purposes only.<\/p>\n<p>               14.2. Reports to Members. As promptly as practicable following<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthe end of each Fiscal Year, the Board of Managers shall cause to be prepared<br \/>\nand mailed to each Member a report setting forth as of the end of such Fiscal<br \/>\nYear (i) the assets and liabilities of the Company, (ii) the Net Profit and Net<br \/>\nLoss of the Company and (iii) such Member&#8217;s Capital Account balance and the<br \/>\nmanner of calculation thereof. After the end of each Fiscal Year, the Board of<br \/>\nManagers shall cause to be prepared and delivered, as promptly as practicable, a<br \/>\nfederal income tax form K-1 for each Member.<\/p>\n<p>               14.3. Final Accounting. Following the date on which the Company<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nis dissolved and liquidated pursuant to Article 12, an independent accounting<br \/>\nfirm selected by the Board of Managers shall commence to take an account of the<br \/>\naffairs and financial transactions of the Company and shall prepare a statement<br \/>\nsetting forth the financial position of the Company as of the close of business<br \/>\non the date the dissolution and liquidation of the Company is completed pursuant<br \/>\nto Article 12 establishing reasonable reserves for contingencies, showing the<br \/>\namount of each Member&#8217;s share of the profits or losses of the Company through<br \/>\nsuch date and stating each Member&#8217;s Capital Account balance on such date.<\/p>\n<p>                                     -31-<\/p>\n<p>                                  ARTICLE 15<\/p>\n<p>                   LIMITATION ON LIABILITY; INDEMNIFICATION<br \/>\n                   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>               15.1. Limitation on Members&#8217; Liability. Except as otherwise<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nrequired by the LLC Act, the debts, obligations and liabilities of the Company,<br \/>\nwhether arising in contract, tort or otherwise, shall be solely the debts,<br \/>\nobligations and liabilities of the Company, and none of the Members or any<br \/>\nManagers or Officers appointed pursuant to Article 6 hereof (collectively, the<br \/>\n&#8220;Protected Parties&#8221;) shall be obligated personally for any such debt, obligation<br \/>\n &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nor liability of the Company solely by reason of being a Member, Manager or<br \/>\nOfficer, or by reason of participating in the management of the Company. The<br \/>\nfailure of the Company to observe any formalities or requirements relating to<br \/>\nthe exercise of its powers or management of its business or affairs under the<br \/>\nLLC Act or this Agreement shall not be grounds for imposing personal liability<br \/>\non the Members for liabilities of the Company.<\/p>\n<p>               15.2. Limitation on Protected Parties&#8217; Liability. None of the<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nProtected Parties shall have any liability to the Company or to any other Member<br \/>\nor to any shareholders, members, principals, officers, directors or employees of<br \/>\nany other Member for any Damages claimed by reason of any act or omission to act<br \/>\non behalf of the Company or otherwise in connection with this Agreement,<br \/>\nprovided that this release from liability shall not apply to the extent that<br \/>\nsuch action or failure to act has been found by a final judgment of a court of<br \/>\ncompetent jurisdiction to have constituted gross negligence or willful<br \/>\nmisconduct.<\/p>\n<p>               15.3. Indemnification of the Protected Parties. The Company shall<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nindemnify and hold harmless the Protected Parties for any Damages incurred by<br \/>\nany of them by reason of any act or omission or alleged act or omission arising<br \/>\nout of the activities of the Protected Parties in connection with this<br \/>\nAgreement, any Portfolio Investment, or the Company provided that this<br \/>\nindemnification shall not apply to the extent that such action or failure to act<br \/>\nhas been found by a final judgment of a court of competent jurisdiction to have<br \/>\nconstituted gross negligence or willful misconduct of the applicable Protected<br \/>\nParties, or with respect to which indemnification is not obtainable under the<br \/>\nsecurities laws of the United States or any other law. If the foregoing<br \/>\nindemnity is unavailable to any Protected Party, then the Company shall<br \/>\ncontribute to the maximum extent permitted by law to the amount paid or payable<br \/>\nby the Protected Party.<\/p>\n<p>               15.4. No Liability for Acts of Agents. None of the Protected<br \/>\n                     &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nParties shall be liable for any act or omission of any third party with respect<br \/>\nto the Company as long as the same is retained by the Board of Managers in good<br \/>\nfaith and with reasonable care and diligence.<\/p>\n<p>                                     -32-<\/p>\n<p>     15.5.  General. (a) The termination of any proceeding by settlement shall<br \/>\n            &#8212;&#8212;-<br \/>\nnot, of itself, create a presumption that a Protected Party acted in a manner<br \/>\nwhich constituted gross negligence or willful misconduct. The right of any<br \/>\nProtected Party to the indemnification provided herein shall be cumulative with,<br \/>\nand in addition to, any and all rights to which such Protected Party may<br \/>\notherwise be entitled by contract or as a matter of law or equity and shall<br \/>\nextend to its successors.<\/p>\n<p>     (b)  All judgments against the Company and a Protected Party, with respect<br \/>\nto which a Protected Party is entitled to indemnification, shall first be<br \/>\nsatisfied from Company assets to the extent available.<\/p>\n<p>     (c)  To the extent that insurance from third parties has been obtained and<br \/>\nis available in respect of any Damages, the Board of Managers will use its best<br \/>\nefforts to have such Damages paid out of the proceeds of such insurance rather<br \/>\nthan having the Company make any payments pursuant to the indemnification<br \/>\nobligations contained herein; provided, however, that if such proceeds are not<br \/>\n                              &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nreadily available, the Board of Managers shall cause the Company to pay such<br \/>\nDamages, in which event the Company will be entitled to reimbursement therefor<br \/>\nout of the proceeds of insurance when and if obtained.<\/p>\n<p>     15.6.  Survival. The provisions of this Article 15 shall survive the<br \/>\n            &#8212;&#8212;&#8211;<br \/>\ntermination of this Agreement and the dissolution and liquidation of the<br \/>\nCompany.<\/p>\n<p>                                  ARTICLE 16<\/p>\n<p>                                 MISCELLANEOUS<br \/>\n                                 &#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>     16.1.  Special Power of Attorney. Each Member hereby irrevocably makes,<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nconstitutes and appoints the Board of Managers, and such other Person or Persons<br \/>\nas the Board of Managers may designate, with full power of substitution, its<br \/>\ntrue and lawful representative and attorney-in-fact (acting in such capacity,<br \/>\nthe &#8220;Attorney-in-Fact&#8221;), in the name, place and stead of such Member, with the<br \/>\n     &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\npower from time to time to make, execute, sign, acknowledge, swear to, verify,<br \/>\ndeliver, record, file and\/or publish: (a) all certificates and other instruments<br \/>\nwhich the Board of Managers may deem appropriate, to form, qualify or continue<br \/>\nthe Company as a limited liability company in the State of Delaware, and all<br \/>\nother jurisdictions in which the Company conducts or plans to conduct business<br \/>\nand to change the name of the Company; (b) all conveyances and other instruments<br \/>\nwhich the Board of Managers may deem appropriate to reflect the dissolution and<br \/>\ntermination of the Company pursuant to the terms hereof, including any writing<br \/>\nrequired by the LLC Act to cancel the Company; and (c) a certificate of assumed<br \/>\nname and such other certificates and instruments as may be necessary under the<br \/>\nfictitious or assumed name statutes from time to time in effect in the State of<br \/>\nDelaware, and all other jurisdictions in which the Company conducts or plans to<br \/>\nconduct business. <\/p>\n<p>                                     -33-<\/p>\n<p>This power-of-attorney is a special power-of-attorney and is coupled with an<br \/>\ninterest in favor of the Attorney-in-Fact and as such (i) shall be irrevocable,<br \/>\nand (ii) may be exercised for such Member by a facsimile signature of the<br \/>\nAttorney-in-Fact.<\/p>\n<p>     16.2.  Amendments. This Agreement may not be amended without the written<br \/>\n            &#8212;&#8212;&#8212;-<br \/>\nconsent of each of the following: (i) Merck, and (ii) the Executive Agent;<br \/>\nprovided, however, that no amendment to this Agreement shall (A) reduce the<br \/>\n&#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\ndistributions to which a Member is entitled under this Agreement or extend the<br \/>\ntime for making such distributions or the form or currency in which such<br \/>\ndistributions are made or adversely affect the rights of such Member under<br \/>\nSection 5.5(c), 8.3 or 12.4, without the consent of each Member affected<br \/>\nthereby, or (B) adversely affect the rights of Lofberg under Article 7 or<br \/>\nSection 5.5, 6.1(b)(i), 6.4, 6.5, 6.13, 8.1(d), 8.5, 9.3(a), 10.2(a), (b) or<br \/>\n(c), 13.2, 13.4 or this Section 16.2 of the Agreement, without Lofberg&#8217;s consent<br \/>\nor (C) adversely affect the rights of the Other Investor Members under Section<br \/>\n8.2(d) through (h) without the consent of the majority of the Other Members.<\/p>\n<p>     16.3.  Binding Effects; Benefits. This Agreement shall be binding upon and<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\ninure to the benefit of the Members hereto and their legal representatives and<br \/>\npermitted successors, as applicable. No Person, other than the Members, shall be<br \/>\nentitled to any benefits under this Agreement, except as otherwise expressly<br \/>\nprovided herein.<\/p>\n<p>     16.4.  Headings. The article, section and other headings of this Agreement<br \/>\n            &#8212;&#8212;&#8211;<br \/>\nare for reference purposes only and shall not affect the meaning or<br \/>\ninterpretation of this Agreement.<\/p>\n<p>     16.5.  Counterparts. This Agreement may be executed in any number of<br \/>\n            &#8212;&#8212;&#8212;&#8212;<br \/>\ncounterparts, each of which shall be deemed to be an original and all of which<br \/>\ntogether shall be deemed to be one and the same agreement.<\/p>\n<p>     16.6.  Grammatical Construction. Whenever the context may require, any<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\npronouns used herein shall include the corresponding masculine, feminine and\/or<br \/>\nneuter forms, and the singular form of nouns and pronouns shall include the<br \/>\nplural and vice versa.<\/p>\n<p>     16.7.  Separability. Any term or provision of this Agreement which is<br \/>\n            &#8212;&#8212;&#8212;&#8212;<br \/>\ninvalid or unenforceable in any jurisdiction shall, as to such jurisdiction, be<br \/>\nineffective to the extent of such invalidity or unenforceability without<br \/>\nrendering invalid or unenforceable the remaining terms or provisions of this<br \/>\nAgreement or affecting the validity or enforceability of any of the terms or<br \/>\nprovisions of this Agreement in any other jurisdiction.<\/p>\n<p>     16.8.  Waiver. No waiver of any breach or condition of this Agreement shall<br \/>\n            &#8212;&#8212;<br \/>\nbe deemed to be a waiver of any other subsequent breach or condition, whether of<br \/>\nlike or different nature.<\/p>\n<p>                                     -34-<\/p>\n<p>     16.9.  Entire Agreement. Other than the employment agreements of even date<br \/>\n            &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nherewith between Merck and Lofberg and Merck and Cooper and the Former<br \/>\nAgreements referred to therein, this Agreement constitutes the entire agreement<br \/>\namong the parties hereto and supersedes any prior agreements, understandings and<br \/>\narrangements, oral or written, among the parties hereto.<\/p>\n<p>     16.10. Notices. (a) Any notice or other communication in connection with<br \/>\n            &#8212;&#8212;-<br \/>\nthis Agreement may be made in writing delivered personally or by courier, or<br \/>\nsent by facsimile transmission (with confirmation slip showing receipt at<br \/>\ncorrect number) or by certified or registered mail and shall be addressed to the<br \/>\nintended recipient at its address or number initially specified as follows:<\/p>\n<p>                  if to the Board of Managers:<\/p>\n<p>                           Merck Capital Ventures, LLC<br \/>\n                           c\/o Merck &amp; Co. Inc.<br \/>\n                           1 Merck Drive<br \/>\n                           Whitehouse Station, NJ  08889<br \/>\n                           Fax  No.: (908) 735 1244<br \/>\n                           Attn:  Ken Frazier<\/p>\n<p>                  if to the Members:<br \/>\n                  at the addresses set forth in Schedule A.<\/p>\n<p>     (b)  The addresses specified above may be changed by either party at any<br \/>\ntime in writing delivered to the other party in accordance with this Section<br \/>\n16.10. Any such notice is deemed to be given as follows: (i) if in writing and<br \/>\ndelivered in person or by courier, on the date when it is delivered; (ii) if by<br \/>\nfacsimile, when received at correct number (proof of which shall be an original<br \/>\nfacsimile transmission confirmation slip or equivalent); or (iii) if sent by<br \/>\ncertified or registered mail (airmail, if overseas) or the equivalent (return<br \/>\nreceipt requested), on the date that mail is delivered or its delivery is<br \/>\nattempted, unless the date of that delivery (or attempted delivery) or that<br \/>\nreceipt, as applicable, is not a working day in the recipient&#8217;s city or that<br \/>\ncommunication is delivered (or attempted) or received, as applicable, after the<br \/>\nclose of business on a working day in the recipient&#8217;s city in which case that<br \/>\ncommunication shall be deemed given and effective on the first following day<br \/>\nthat is a working day in the recipient&#8217;s city.<\/p>\n<p>     16.11.  Insurance. The Board of Managers may cause the Company to purchase<br \/>\n             &#8212;&#8212;&#8212;<br \/>\nand maintain, at the expense of the Company, insurance on behalf of the Company<br \/>\nor its Members or any Officer, Manager or agent of the Company against any<br \/>\nliability asserted against any of them or incurred by any of them in any such<br \/>\ncapacity or <\/p>\n<p>                                     -35-<\/p>\n<p>arising out of their status as such, whether or not the Company would have the<br \/>\npower to indemnify any of them against such liability under the provisions of<br \/>\nthis Agreement.<\/p>\n<p>     16.12.  Disclosure of Investment. The Company and each of the Members<br \/>\n             &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nagree, and each Member and the Board of Managers will use reasonable best<br \/>\nefforts to procure that any Portfolio Company in which the Company is to make a<br \/>\nPortfolio Investment will agree, that, from the date hereof, no public release<br \/>\nor announcement concerning the transactions contemplated by this Agreement,<br \/>\nincluding without limitation, the formation of the Company and the consummation<br \/>\nof a Portfolio Investment in a Portfolio Company (or the contemplation thereof),<br \/>\nshall be issued by any party without the prior consent of Merck in its sole<br \/>\ndiscretion except (i) as such release or announcement may be required by<br \/>\n           &#8212;&#8212;<br \/>\napplicable securities law or the rules or regulations of the United States<br \/>\nSecurities and Exchange Commission, (ii) if a Portfolio Company reasonably<br \/>\nconsiders that such a public release or announcement is in the best interests of<br \/>\nthe Portfolio Company, in which case the party required or electing to make the<br \/>\nrelease or announcement shall make its reasonable best efforts to allow Merck<br \/>\nreasonable time to comment on such release or announcement in advance of such<br \/>\nissue or (iii) if such public release or announcement does not include a<br \/>\nreference to Merck or any of its Affiliates or to the Merck name.<\/p>\n<p>     16.13.  Arbitration. (a) Except for determinations of whether Protected<br \/>\n             &#8212;&#8212;&#8212;&#8211;<br \/>\nParties are entitled to a release from liability or indemnification in<br \/>\naccordance with Sections 15.2 and 15.3, any controversy, dispute or claim<br \/>\narising under this Agreement or any breach thereof shall be settled by<br \/>\narbitration conducted in accordance with this Section 16.13 in the County of New<br \/>\nYork, in accordance with the then existing rules of the American Arbitration<br \/>\nAssociation, and judgment upon any award rendered by the arbitrator may be<br \/>\nentered by any United States federal or state court having jurisdiction thereof,<br \/>\nprovided that the foregoing shall not limit the Company&#8217;s right to seek an<br \/>\ninjunction or other equitable relief. Any such arbitration shall be conducted by<br \/>\na single arbitrator, and, in the case of any dispute with respect to accounting<br \/>\nissues, the arbitrator (the &#8220;Arbitrator&#8221;) shall be a partner of a &#8220;Big Five&#8221;<br \/>\n                             &#8212;&#8212;&#8212;-<br \/>\naccounting firm other than the Company&#8217;s accountants. If the parties are unable<br \/>\nto agree upon an arbitrator within 5 Business Days of any Member requesting the<br \/>\nappointment thereof, then an arbitrator shall be appointed in accordance with<br \/>\nthe rules of the American Arbitration Association. The parties intend that this<br \/>\nagreement to arbitrate be valid, enforceable and irrevocable and that any<br \/>\ndetermination reach pursuant to the foregoing procedure shall be final and<br \/>\nbinding on the parties absent fraud. Each party shall bear their own costs and<br \/>\nexpenses of any such arbitration and all of the fees and expenses of the<br \/>\narbitrator shall be paid as to 50% by Merck and 50% by the other parties to the<br \/>\nArbitration in proportion to their respective Maximum Amounts.<\/p>\n<p>     (b)  A party seeking to enforce its rights pursuant to this Section 16.13<br \/>\nshall submit to the Arbitrator, with a copy sent to all other Members to the<br \/>\ndispute, a <\/p>\n<p>                                     -36-<\/p>\n<p>notice of the existence of the dispute and a brief description of the action<br \/>\ngiving rise to the dispute (such submission, a &#8220;Dispute Notice&#8221;).<br \/>\n                                                &#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>          (c)  No later than the close of business on the second Business Day<br \/>\nfollowing submission of the Dispute Notice to the Arbitrator, representatives of<br \/>\nthe relevant Members shall meet in person or by teleconference with the<br \/>\nArbitrator and at such meeting the Arbitrator shall determine the process by<br \/>\nwhich the dispute (including scheduling presentations to him) shall be resolved<br \/>\nwithin 20 Business Days following submission of the Dispute Notice to him<br \/>\n(subject to extension for good cause). The relevant Members shall provide the<br \/>\nArbitrator with all the information the Arbitrator deems necessary within the<br \/>\ntime period specified by the Arbitrator.<\/p>\n<p>          (d)  The Arbitrator shall deliver a written report to the relevant<br \/>\nMembers and a copy to the Company of his determination as to the dispute by the<br \/>\ntenth Business Day following submission of the Dispute Notice to him (subject to<br \/>\nextension for good cause). Such report shall set forth the basis for such<br \/>\ndetermination and shall constitute an arbitral award that is final, binding and<br \/>\nunappealable under the Federal Arbitration Act, 9 U.S.C. (S)(S) 1 et seq. (the<br \/>\n&#8220;FAA&#8221;).<br \/>\n &#8212;<\/p>\n<p>     16.14.    Appointment of Executive Agent. Until his successor as Executive<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nAgent shall have been designated in the manner hereafter provided and, in any<br \/>\nevent, for so long as he is the Chief Executive Officer of the Company, Lofberg<br \/>\nshall act as the sole agent (the &#8220;Executive Agent&#8221;) for each Carry Member and<br \/>\neach Other Investor Member (collectively, the &#8220;Non-Merck Members&#8221;) and shall,<br \/>\n                                               &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nexcept as provided in Sections 5.5(c), 16.2 and this Section 16.14 be authorized<br \/>\nto exercise all rights of the Non-Merck Members hereunder. Except as provided in<br \/>\nSections 5.5(c), 16.2 and this Section 16.14, the Executive Agent will have sole<br \/>\npower and authority to take any action on behalf of the Non-Merck Members<br \/>\npursuant to this Agreement, including delivering any notice or granting any<br \/>\nwaiver or consent hereunder, and Merck shall be entitled to rely on any action<br \/>\ntaken by the Executive Agent as being taken on behalf of any or all of the Non-<br \/>\nMerck Members as the case requires. Except as provided in Sections 5.5(c), 16.2<br \/>\nand this Section 16.14, the rights of the Non-Merck Members under this Agreement<br \/>\nshall be exercised only by the Executive Agent on behalf of such Non-Merck<br \/>\nMembers and no such Non-Merck Member shall be separately authorized to exercise<br \/>\nany such rights. Any notice required to be delivered to any Non-Merck Member<br \/>\nshall be deemed delivered if delivered to the Executive Agent. If Lofberg ceases<br \/>\nto be Chief Executive Officer of the Company, a majority of the Carry Members<br \/>\nmay from time to time, by written notice to the Company and Merck, appoint a<br \/>\nreplacement Executive Agent, who shall serve as Executive Agent until replaced<br \/>\nas provided in this sentence.<\/p>\n<p>     16.15.    Payments on Business Days. Any payment required to be made<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nhereunder on a day which is not a Business Day shall be made on the next<br \/>\nsucceeding Business Day.<\/p>\n<p>                                     -37-<\/p>\n<p>     16.16.    Governing Law. This Agreement shall be governed by and construed<br \/>\n               &#8212;&#8212;&#8212;&#8212;-<br \/>\nboth as to validity and enforceability in accordance with the laws of the State<br \/>\nof Delaware, without regard to the conflict of laws provisions thereof.<\/p>\n<p>     [Remainder of Page is Intentionally Blank]<\/p>\n<p>                                     -38-<\/p>\n<p>     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of<br \/>\nthe date first above written.<\/p>\n<p>                              Merck-Medco Managed Care, L.L.C.<\/p>\n<p>                              By:  ________________________________________<br \/>\n                                   Name:<br \/>\n                                   Title:<\/p>\n<p>                                   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n                                              Per G.H. Lofberg<\/p>\n<p>                                    &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n                                                James Cooper<\/p>\n<p>                                     -39-<\/p>\n<p>                                                                      APPENDIX A<br \/>\n                                                                      &#8212;&#8212;&#8212;-<\/p>\n<p>                                 DEFINITIONS<br \/>\n                                 &#8212;&#8212;&#8212;&#8211;  <\/p>\n<p>                                      -1-<\/p>\n<p>          As used in the foregoing Agreement, the following terms shall have the<br \/>\nmeanings set forth below:<\/p>\n<p>          &#8220;Acquisition Cost&#8221; means the amount of Capital Contributions invested<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nin a Portfolio Investment, excluding any Fees and Expenses incurred in<br \/>\nconnection therewith.<\/p>\n<p>          &#8220;Affiliate&#8221; means, with respect to any Person, any other Person,<br \/>\n           &#8212;&#8212;&#8212;<br \/>\ndirectly or indirectly, through one or more intermediaries, controlling,<br \/>\ncontrolled by, or under common control with such Person. The term &#8220;control,&#8221; as<br \/>\nused in the immediately preceding sentence means, with respect to any Person,<br \/>\nthe possession, directly or indirectly, of the power to direct or cause the<br \/>\ndirection of the management or policies of the controlled Person.<\/p>\n<p>          &#8220;Agreement&#8221; shall have the meaning set forth in the Recitals.<br \/>\n           &#8212;&#8212;&#8212;<\/p>\n<p>          &#8220;Applicable Carried Interest&#8221; means:<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>           (a)  with respect to Lofberg, (i) from the date of this Agreement to<br \/>\nthe first anniversary of this Agreement, 0%, (ii) from and after the first<br \/>\nanniversary of this Agreement to the second anniversary of this Agreement, 6%,<br \/>\nand (iii) thereafter, 12%;<\/p>\n<p>          (b)   with respect to Cooper, (i) from the date of this Agreement to<br \/>\nthe first anniversary of this Agreement, 0%, (ii) from and after the first<br \/>\nanniversary of this Agreement to the second anniversary of this Agreement,<br \/>\n1.25%, and (iii) thereafter, 2.5%;<\/p>\n<p>          (c)   with respect to any other Carry Member, as determined by the<br \/>\nBoard of Managers and set forth in a resolution of the Board, provided, however,<br \/>\nthat the Applicable Carried Interest of a Carry Member shall be 0% in respect of<br \/>\nany Portfolio Investment:<\/p>\n<p>          (1)   made or committed to be made by the Company prior to the Start<br \/>\n                Date for such Carry Member; or<\/p>\n<p>          (2)   made by the Company after the End Date for such Carry Member,<br \/>\n                and provided further, that:<\/p>\n<p>          (A)   in the case of a Carry Member whose employment by Merck or any<br \/>\n                of its Affiliates is terminated without Cause, or as a result of<br \/>\n                such Carry Member&#8217;s Death or Disability or, in the case of<br \/>\n                Lofberg, if Lofberg terminates his employment with the Company<br \/>\n                for Good Reason, the Applicable Carried Interest of such Carry<br \/>\n                Member in respect of any Portfolio Investment made on or after<br \/>\n                the Start Date and on or before the End Date for such Carry<br \/>\n                Member, shall be such<\/p>\n<p>                                      -1-<\/p>\n<p>               Carry Member&#8217;s Maximum Amount; and<\/p>\n<p>          (B)  in the case of a Carry Member whose employment by Merck or any of<br \/>\n               its Affiliates is terminated for any reason other than the<br \/>\n               reasons set out in paragraph (A) of this definition, the<br \/>\n               Applicable Carried Interest of such Carry Member in respect of<br \/>\n               any Portfolio Investment made on or after the Start Date and on<br \/>\n               or before the End Date for such Carry Member, shall be the<br \/>\n               Applicable Carried Interest in effect at the End Date for such<br \/>\n               Carry Member.<\/p>\n<p>          &#8220;Applicable Employer&#8221; shall have the meaning set forth in Section 8.5.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>          &#8220;Applicable Portfolio Investment&#8221; is defined in the definition of<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nNegative Carry Balance.<\/p>\n<p>          &#8220;Applicable Tax Rate&#8221; in respect of a Member, means that Member&#8217;s<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nmarginal tax rate for the applicable Fiscal Year, taking into account, where<br \/>\napplicable, the deductibility of state and local taxes paid for federal tax<br \/>\npurposes, such Member&#8217;s eligibility for a lower rate on long-term capital gains,<br \/>\nand any preferential rate or exemption to which such Member is actually<br \/>\nentitled.<\/p>\n<p>          &#8220;Applicable Valuation Date&#8221; means:<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>          (a)  in the case of Section 10.2(b), the 20\/th\/ Business Day following<br \/>\nthe date the Divestment Proposal is recommended to the Board of Managers by<br \/>\nLofberg; and<\/p>\n<p>          (b)  in the case of Section 10.2(d), a date mutually agreed to by the<br \/>\nMembers, or if no valuation date is agreed upon, December 31, 2010.<\/p>\n<p>          &#8220;Associate&#8221; has the meaning set forth in Rule 12b-2 under the<br \/>\n           &#8212;&#8212;&#8212;<br \/>\nSecurities Exchange Act of 1934.<\/p>\n<p>          &#8220;Attorney-in-Fact&#8221; shall have the meaning set forth in Section 16.1.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>          &#8220;Attributable Carry Member Costs&#8221; shall mean, with respect to any<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nPortfolio Investment, an amount equal to the cumulative previously unrecovered<br \/>\nCarry Member Costs incurred during the Expenses Period multiplied by a fraction,<br \/>\n(x) the numerator of which is the Acquisition Cost of such Portfolio Investment<br \/>\nand (y) the Denominator of which is (i) the aggregate Acquisition Costs of all<br \/>\nPortfolio Investments less (ii) the aggregate Acquisition Costs of Portfolio<br \/>\nInvestments that have been Sold other than such Portfolio Investment.<\/p>\n<p>          &#8220;Attributable Fees and Expenses&#8221; shall mean, with respect to any<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nPortfolio Investment, an amount equal to the cumulative previously unrecovered<br \/>\nFees and Expenses of the Company incurred during the Expenses Period which were<br \/>\nfunded by a<\/p>\n<p>                                      -2-<\/p>\n<p>Capital Contribution of Merck multiplied by a fraction, (x) the numerator of<br \/>\nwhich is the Acquisition Cost of such Portfolio Investment and (y) the<br \/>\nDenominator of which is (i) the aggregate Acquisition Costs of all Portfolio<br \/>\nInvestments less (ii) the aggregate Acquisition Costs of Portfolio Investments<br \/>\nthat have been Sold other than such Portfolio Investment.<\/p>\n<p>          &#8220;Available Cash&#8221; means Cash which is available in the accounts of the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nCompany and not reserved to make any payments due and owing by the Company or<br \/>\notherwise reserved by the Board of Managers, in its reasonable discretion, for<br \/>\nFees and Expenses, operations, or contingencies of the Company.<\/p>\n<p>          &#8220;Base Commitment&#8221; shall mean, as to Merck, the Merck Base Commitment<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nand, as to each Other Investor Member, an amount equal to the Other Investor<br \/>\nMembers Base Commitment multiplied by such Other Investor Member&#8217;s Ratable<br \/>\nContribution Percentage.<\/p>\n<p>          &#8220;Benefiting Member&#8221; has the meaning set forth in Section 8.3(a).<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211; <\/p>\n<p>          &#8220;Board of Managers&#8221; and &#8220;Board&#8221; shall have the meaning set forth in<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;       &#8212;&#8211;<br \/>\nSection 6.1.<\/p>\n<p>          &#8220;Bona Fide Third Party Offer&#8221; means a bona fide offer by a third party<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthat is not an Affiliate or Associate of the Company or any Member to acquire<br \/>\nthe Company&#8217;s entire interest in a Portfolio Company for cash, which offer:<\/p>\n<p>          (a)  shall not be subject to financing, due diligence or other<br \/>\ncontingencies that in the reasonable judgment of the Board of Managers create a<br \/>\nreasonable risk of delay or failure provided, however, that this paragraph (a)<br \/>\nshall not apply in respect of an offer that otherwise satisfies the definition<br \/>\nfrom an offeror who is bound by a customary confidentiality agreement with a<br \/>\nPortfolio Company if Merck unreasonably prevents such third party from<br \/>\nperforming customary due diligence investigations;<\/p>\n<p>          (b)  shall include evidence reasonably satisfactory to Board of the<br \/>\nofferor&#8217;s ability to pay the purchase price;<\/p>\n<p>          (c)  shall not include surviving representations and warranties or<br \/>\nindemnities (other than in respect of title); and<\/p>\n<p>          (d)  shall not be subject to post-closing purchase price adjustments<br \/>\nor earn-outs.<\/p>\n<p>          &#8220;Book Value&#8221; means:<br \/>\n           &#8212;&#8212;&#8212;-<\/p>\n<p>          (a)  with respect to any asset, the asset&#8217;s adjusted basis for federal<\/p>\n<p>                                      -3-<\/p>\n<p>income tax purposes, except that, in accordance with the rules set forth in<br \/>\nReg. (S) 1.704-1(b)(iv)(f):<\/p>\n<p>          (i)   The initial Book Value of the assets of the Company as of the<br \/>\n     date of the contribution or deemed contribution shall be their respective<br \/>\n     gross Fair Market Values at such time as reasonably determined by the Board<br \/>\n     of Managers;<\/p>\n<p>          (ii)  The Book Value of any asset distributed or deemed distributed by<br \/>\n     the Company to any Member shall be adjusted immediately prior to such<br \/>\n     distribution to equal its gross Fair Market Value at such time as<br \/>\n     reasonably determined by the Board of Managers;<\/p>\n<p>          (iii) The Book Values of all Company assets may be adjusted in the<br \/>\n     discretion of the Board of Managers to equal their respective gross Fair<br \/>\n     Market Values, as reasonably determined by the Board of Managers as of:<\/p>\n<p>               (1)  The date of the acquisition of an additional interest in the<br \/>\n                    Company by any new or existing Member in exchange for a<br \/>\n                    Capital Contribution to the Company; or<\/p>\n<p>               (2)  Any distribution in liquidation of the Company, or the<br \/>\n                    distribution by the Company to a retiring or continuing<br \/>\n                    Member of money or other assets of the Company in reduction<br \/>\n                    of such Member&#8217;s Membership Interest in the Company;<\/p>\n<p>          (iv)  Any adjustments to the adjusted basis of any asset of the<br \/>\n     Company pursuant to Sections 734 or 743 of the Code shall be taken into<br \/>\n     account in determining such asset&#8217;s Book Value in a manner consistent with<br \/>\n     Reg. (S) 1.704-1(b)(2)(iv)(m); and<\/p>\n<p>          (v)  If the Book Value of an asset has been determined pursuant to<br \/>\n     clauses (i) through (iv) above, to the extent permitted under the Income<br \/>\n     Tax Regulations, such Book Value shall thereafter be adjusted in the same<br \/>\n     manner as would the asset&#8217;s adjusted tax basis for federal income tax<br \/>\n     purposes, except that depreciation and amortization deductions shall be<br \/>\n     computed based on the asset&#8217;s Book Value as so determined, and not on the<br \/>\n     asset&#8217;s adjusted tax basis in a manner consistent with Reg. (S) 1.704-<br \/>\n     1(b)(2)(iv)(g)(3) or 1.704-3(d)(2), as applicable; and<\/p>\n<p>     (b)  with respect to any liability, at a given time, the amount of such<br \/>\nliability to the extent:<\/p>\n<p>                                      -4-<\/p>\n<p>               (i)    reflected in the basis of any asset;<\/p>\n<p>               (ii)   previously or currently deductible in computing Net<br \/>\n          Profit, Net Loss or items of income, deduction or expense for Capital<br \/>\n          Account maintenance purposes; or<\/p>\n<p>               (iii)  otherwise previously taken into account for Capital<br \/>\n          Account maintenance purposes.<\/p>\n<p>          &#8220;Break-Up Expenses&#8221; means all expenses incurred by the Company in<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nconnection with any Portfolio Investment that is not consummated, provided (a) a<br \/>\nterm sheet and letter of intent for such Portfolio Investment has been approved<br \/>\nby the Board of Managers or (b) such Portfolio Investment does not require<br \/>\napproval of the Board of Managers and has been approved by Lofberg.<\/p>\n<p>          &#8220;Business Day&#8221; means any day excluding Saturday, Sunday and any day<br \/>\n           &#8212;&#8212;&#8212;&#8212;<br \/>\nwhich shall be in the City of New York a legal holiday or a day on which banking<br \/>\ninstitutions are authorized by law or other government action to close.<\/p>\n<p>          &#8220;Capital Account&#8221; means, with respect to any Member, the capital<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\naccount of such Member maintained pursuant to Section 9.1, including all<br \/>\nadditions and subtractions thereto, pursuant to this Agreement.<\/p>\n<p>          &#8220;Capital Contributions&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n5.1(a).<\/p>\n<p>          &#8220;Carry Distributions&#8221; shall mean all amounts distributed to the Carry<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nMembers pursuant to the proviso in Section 10.1(b)(iii).<\/p>\n<p>          &#8220;Carry Interest&#8221; shall mean the interest of the Carry Members in<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ndistributions made or to be made by the Company under this Agreement.<\/p>\n<p>          &#8220;Carry Members&#8221; has the meaning set forth in the Preamble and includes<br \/>\n           &#8212;&#8212;&#8212;&#8212;-<br \/>\nany person who is designated as a Carry Member pursuant to Section 5.5.<\/p>\n<p>          &#8220;Carry Member Costs&#8221; means all costs and expenses (excluding severance<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\ncosts of terminated employees (other than Carry Members) and the initial costs,<br \/>\nsuch as headhunter&#8217;s fees and relocation expenses, of hiring new employees to<br \/>\nreplace employees seconded to the Company) incurred by Merck or any of its<br \/>\nAffiliates (other than the Company) in connection with the employment of any<br \/>\nperson who is seconded to the Company pursuant to this Agreement or is a Carry<br \/>\nMember or Designated Additional Carry Member, during the period that such person<br \/>\nis employed to provide such services or be such Carry Member or Designated<br \/>\nAdditional Carry Member, including, without limitation, any base compensation,<br \/>\nany overtime compensation, any bonus and any compensation related expenses and<br \/>\nthe amount of any other employee benefits (including <\/p>\n<p>                                      -5-<\/p>\n<p>welfare and pension benefits) in the amount (equal to 36% of the base salary<br \/>\nplus overtime of such person) billed by Merck or its Affiliates to the relevant<br \/>\nbusiness division of the entity that employs such employee.<\/p>\n<p>          &#8220;Cash&#8221; when capitalized means money and cash equivalents.<br \/>\n           &#8212;-<\/p>\n<p>          &#8220;Cause&#8221; shall have the meaning set forth in the applicable employment<br \/>\n           &#8212;&#8211;<br \/>\nagreement between the entity employing the Carry Member and the Carry Member or,<br \/>\nif there is no employment agreement, shall mean (i) the continued failure by the<br \/>\nCarry Member to substantially perform the Carry Member&#8217;s duties with the Company<br \/>\n(other than any such failure resulting from the Carry Member&#8217;s incapacity due to<br \/>\nphysical or mental illness), (ii) the Carry Member&#8217;s engaging in conduct which<br \/>\nis demonstrably and materially injurious to the Company or any of its<br \/>\nAffiliates, monetarily or otherwise, (iii) the conviction of the Carry Member<br \/>\nfor the commission of (A) a felony or (B) any other crime involving moral<br \/>\nturpitude, (iv) the Carry Member&#8217;s material violation of any employment policies<br \/>\nor applicable codes of conduct of the Company, Merck or an Affiliate of Merck ,<br \/>\nor (v) a material breach by the Carry Member of any employee covenants to which<br \/>\nsuch an Carry Member is subject.<\/p>\n<p>          &#8220;Certificate of Formation&#8221; means the limited liability certificate of<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nthe Company and any amendments thereto.<\/p>\n<p>          &#8220;Clinical Development Entity&#8221; means any private emerging entity<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nengaged in innovative ways to manage documentation and information processing,<br \/>\nphysician and patient recruitment, information analysis, communications and site<br \/>\nmanagement all with the goal of shortening pharmaceutical development time<br \/>\nframes and\/or lowering pharmaceutical development costs. Nothing in this<br \/>\ndefinition shall restrict the Company&#8217;s power to invest in entities otherwise<br \/>\nsatisfying the definition of E-Healthcare Companies under clause (b) of the<br \/>\ndefinition of such term in Section 4.1.<\/p>\n<p>          &#8220;Code&#8221; means the Internal Revenue Code of 1986, as in effect on the<br \/>\n           &#8212;-<br \/>\ndate of this Agreement and as amended thereafter from time to time.<\/p>\n<p>          &#8220;Company&#8221; shall have the meaning set forth in the Preamble.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;Contributing Member&#8221; means, in respect of a Distributing Investment,<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\neach Investor Member who contributed to the Acquisition Cost of such<br \/>\nDistributing Investment.<\/p>\n<p>          &#8220;Control Acquisition&#8221; means any cash investment prior to termination<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nof the Investment Period (including by way of the cashless exercise of Warrants<br \/>\nAcquired for Cash) by Merck or any of its Affiliates or Associates (other than<br \/>\nthe Company) in a Portfolio Company in which the Company has an existing<br \/>\nPortfolio Investment that (i) is rejected or not approved by Lofberg within the<br \/>\nperiod specified in Section 8.2(b) and<\/p>\n<p>                                      -6-<\/p>\n<p>(ii) upon the consummation of which, the Company, Merck and Merck&#8217;s Affiliates<br \/>\nand Associates would, in the aggregate, own more than 20% of the outstanding<br \/>\nvoting equity of the Portfolio Company.<\/p>\n<p>          &#8220;Control Acquisition Interest&#8221; shall have the meaning set forth in<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nSection 8.2(d).<\/p>\n<p>          &#8220;Control Acquisition Price&#8221; of a Control Acquisition Interest means<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nthe same consideration per share (or equity equivalent) paid or to be paid by<br \/>\nMerck or the applicable Affiliate or Associate under the related Control<br \/>\nAcquisition Agreement.<\/p>\n<p>          &#8220;Cooper&#8221; means James Cooper.<br \/>\n           &#8212;&#8212;<\/p>\n<p>          &#8220;Damages&#8221; means any and all losses, damages, expenses and liabilities<br \/>\n           &#8212;&#8212;-<br \/>\nwhether joint or several, including, without limitation, those losses, damages,<br \/>\nexpenses and liabilities (including reasonable attorneys&#8217; fees) arising under or<br \/>\nconnected with the securities laws of the United States, or any other provision<br \/>\nof statutory law, common law, or other applicable law of any jurisdiction.<\/p>\n<p>          &#8220;Death&#8221; shall mean the death of the Carry Member.<br \/>\n           &#8212;&#8211;    <\/p>\n<p>          &#8220;Designated Additional Carry Member&#8221; shall have the meaning set forth<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nin Section 5.5(a).<\/p>\n<p>          &#8220;Disability&#8221; shall have the meaning set forth in the applicable<br \/>\n           &#8212;&#8212;&#8212;-<br \/>\nemployment agreement between the entity employing the Carry Member and the Carry<br \/>\nMember, or if there is no employment agreement, a Carry Member shall be<br \/>\nconsidered to be disabled after he or she has been unable fully to perform his<br \/>\nor her duties as an employee of the Company (as determined in good faith by the<br \/>\nBoard of Managers), with reasonable accommodation as required by law, by reason<br \/>\nof physical or mental illness for 180 days during any 360 day period.<\/p>\n<p>          &#8220;Distributing Investment&#8221; means, in respect of each distribution under<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nSection 10.1(b), the Portfolio Investment whose Sale gives rise to such<br \/>\ndistribution.<\/p>\n<p>          &#8220;E-Healthcare Companies&#8221; shall have the meaning given to it in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n4.1 of the Agreement.<\/p>\n<p>          &#8220;employee of the Company&#8221; or &#8220;employees&#8221; means any employee of Company<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nor Merck or an Affiliate of Merck who provides services to the Company under the<br \/>\nterms of this Agreement.<\/p>\n<p>          &#8220;End Date&#8221; means the earlier of (i) the date the applicable Carry<br \/>\n           &#8212;&#8212;&#8211;<br \/>\nMember&#8217;s employment with Merck or an Affiliate of Merck is terminated and (ii)<br \/>\ndate the applicable Carry Member&#8217;s designation as a Carry Member is terminated<br \/>\nby the Board of<\/p>\n<p>                                      -7-<\/p>\n<p>Managers pursuant to Section 6.13(l), in each case for any reason, except that<br \/>\nthe End Date shall be the 90\/th\/ day following such termination date in respect<br \/>\nof a Portfolio Investment initiated prior to such termination date and<br \/>\nconsummated on or before such 90th day if the applicable Carry Member&#8217;s<br \/>\nemployment or designation as a Carry Member is terminated without Cause or by<br \/>\nreason of the Carry Member&#8217;s Death or Disability.<\/p>\n<p>          &#8220;Event of Bankruptcy&#8221; means, with respect to any Person, (i) the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nfiling of a voluntary petition seeking liquidation, reorganization, arrangement<br \/>\nor readjustment, in any form, of its debts under Title 11 of the United States<br \/>\nCode or any other federal or state insolvency law, or the filing of an answer<br \/>\nconsenting to or acquiescing in any such petition; (ii) the making of any<br \/>\ngeneral assignment for the benefit of its creditors, or the admission in writing<br \/>\nof its inability to pay debts as they become due; (iii) the expiration of 30<br \/>\ndays after the filing of an involuntary petition under Title 11 of the United<br \/>\nStates Code, an application for the appointment of a receiver for the assets of<br \/>\nsuch Person, or an involuntary petition seeking liquidation, reorganization,<br \/>\narrangement or readjustment of its debts under any other federal, state or<br \/>\nforeign insolvency law, provided that the same shall not have been vacated, set<br \/>\naside or stayed within such 30-day period; (iv) the appointment of a receiver,<br \/>\nliquidator, assignee, custodian, trustee, sequestrator, or other similar agent<br \/>\nfor the Person or for any substantial part of the Person&#8217;s assets or property;<br \/>\nand (v) the ordering of the winding up or liquidation of the Person&#8217;s affairs.<\/p>\n<p>          &#8220;Excess Carry Amount&#8221; means, with respect to each Carry Member, an<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\namount, determined on an aggregate basis for all Portfolio Investments in which<br \/>\nsuch Carry Member has or had a Carry Interest, equal to such amount, if any, by<br \/>\nwhich its Carry Distributions exceed the product of (i) the highest Applicable<br \/>\nCarried Interest of such Carry Member in respect of any Portfolio Investment,<br \/>\nand (ii) the Net Profit Amount of all Portfolio Investments in which such Carry<br \/>\nMember has or had a Carry Interest.<\/p>\n<p>          &#8220;Exchange&#8221; means (i) a United States national, regional, or local<br \/>\n           &#8212;&#8212;&#8211;<br \/>\nsecurities exchange (ii) a foreign securities exchange or (iii) an interdealer<br \/>\nquotation system that regularly disseminates firm buy or sell quotations by<br \/>\nidentified brokers or dealers (including, without limitation, NASDAQ).<\/p>\n<p>          &#8220;Executive Agent&#8221; shall have the meaning set forth in section 16.14.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>          &#8220;Executive Committee&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n8.1(d).<\/p>\n<p>          &#8220;Expenses&#8221; shall mean, collectively, the Organizational Expenses and<br \/>\n           &#8212;&#8212;&#8211;<br \/>\nthe Operating Expenses.<\/p>\n<p>          &#8220;Expenses Period&#8221; means the period commencing on the date of this<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nAgreement and ending on the third anniversary thereof.<\/p>\n<p>                                      -8-<\/p>\n<p>          &#8220;Fair Market Value&#8221; shall mean, as to any non-cash property of the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nCompany, the fair market value thereof as determined pursuant to Section 10.5 of<br \/>\nthe Agreement.<\/p>\n<p>          &#8220;Family Trust&#8221; in respect of any Person means any trust, partnership,<br \/>\n           &#8212;&#8212;&#8212;&#8212;<br \/>\nlimited liability company or other entity, the beneficiaries, partners, members<br \/>\nor other equity owners of which (as the case may be), comprise solely members of<br \/>\nthat Person&#8217;s family, by blood or marriage.<\/p>\n<p>          &#8220;Fees and Expenses&#8221; shall mean, collectively, the Break-Up Expenses,<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nthe Organizational Expenses and the Operating Expenses.<\/p>\n<p>          &#8220;Fiscal Year&#8221; shall have the meaning set forth in Section 2.3.<br \/>\n           &#8212;&#8212;&#8212;&#8211;    <\/p>\n<p>          &#8220;Funding Notice&#8221; shall have the meaning set forth in Section 5.2(a).<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>          &#8220;Good Reason&#8221; shall mean the termination by Lofberg of his employment<br \/>\n           &#8212;&#8212;&#8212;&#8211;<br \/>\nas Chief Executive Officer of the Company following the revocation or suspension<br \/>\nof any of the powers granted to Lofberg pursuant to Section 7 of this Agreement<br \/>\n(other than in connection with the termination of Lofberg for Cause).<\/p>\n<p>          &#8220;GAAP&#8221; means the United States generally accepted accounting<br \/>\n           &#8212;-<br \/>\nprinciples.<\/p>\n<p>          &#8220;Investment Committee&#8221; shall mean a committee appointed by the Board<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nof Managers in accordance with Section 8.1 of the Agreement.<\/p>\n<p>          &#8220;Investment Period&#8221; shall mean the period beginning on the date of<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nthis Agreement and ending on the earlier of (i) the date that all of the Merck<br \/>\nBase Commitment has been invested or committed for investment in Portfolio<br \/>\nInvestments and Merck has advised the Executive Agent in writing that it does<br \/>\nnot intend to make any further investments, (ii) the second anniversary of the<br \/>\ndate of this Agreement or (iii) the termination thereof pursuant to Section 12.2<\/p>\n<p>          &#8220;Investor Members&#8221; shall have the meaning set forth in the Preamble<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nand includes any person who is designated as an Investor Member pursuant to<br \/>\nSection 5.5.<\/p>\n<p>          &#8220;LLC Act&#8221; shall have the meaning set forth in the Recitals.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;Lofberg&#8221; means Per G. H. Lofberg.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;MCV Budget&#8221; has the meaning set forth in Section 8.4.<br \/>\n           &#8212;&#8212;&#8212;-  <\/p>\n<p>          &#8220;majority of the Carry Members&#8221; means Carry Members  holding a<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nmajority of the Carry Interests in respect of a Portfolio  Investment,  assuming<br \/>\nsuch Portfolio <\/p>\n<p>                                      -9-<\/p>\n<p>Investment were incurred on the date of determination and all unvested Carry<br \/>\nInterests were then vested.<\/p>\n<p>          &#8220;majority of the Non-Defaulting Investor Members&#8221; means Non-Defaulting<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nInvestor Members providing a majority by monetary value of the Capital<br \/>\nContributions in respect of a Portfolio Investment.<\/p>\n<p>          &#8220;majority of the Other Members&#8221; means Other Investor Members having a<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nmajority of the Other Investor Interests in the applicable Portfolio Investment.<\/p>\n<p>          &#8220;Marketable Securities&#8221; means securities that (i) are listed and<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\ntraded on a national securities exchange or listed for quotation on the National<br \/>\nAssociation of Securities Dealers, Inc. Automated Quotation System National<br \/>\nMarket System, or registered or otherwise transferable under Rule 144 under the<br \/>\nSecurities Act of 1933, as amended without any waiting period or volume<br \/>\nrestrictions applicable to the Members, (ii) are not subject to any &#8220;lock-up&#8221; or<br \/>\nother contractual restrictions on transfer and (iii) either (A) are not subject<br \/>\nto any limitations on sale or transfer under the Securities Act of 1933, as<br \/>\namended or relevant state blue sky or similar foreign laws or (B) are covered by<br \/>\na registration rights agreement pursuant to which (1) the Company has presently<br \/>\nexercisable registration rights covering 100% of the securities held by the<br \/>\nCompany in the applicable Portfolio Investment, (2) Lofberg has recommended in<br \/>\nwriting to the Board of Managers that such registration rights be exercised, and<br \/>\n(3) the Board of Managers shall have failed to request registration of such<br \/>\nregistrable securities within 30 days of Lofberg&#8217;s recommendation unless the<br \/>\nfailure to request such registration was based upon the Board&#8217;s determination,<br \/>\nafter due inquiry of the Portfolio Company, that there was a reasonable<br \/>\nlikelihood the Portfolio Company would exercise deferral or blackout rights if<br \/>\nthe Company were to exercise such registration rights.<\/p>\n<p>          &#8220;Maximum Amount&#8221; means the maximum Applicable Carried Interest of a<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nCarry Member which is, (a) in respect of Lofberg, 12%, (b) in respect of Cooper,<br \/>\n2.5% and (c) in respect of any other Carry Member, the maximum Applicable<br \/>\nCarried Interest of such Carry Member as specified in the determination of the<br \/>\nBoard of Managers and set forth in the applicable resolution of the Board.<\/p>\n<p>          &#8220;Members&#8221; shall have the meaning set forth in the Preamble.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;Membership Interest&#8221; means the interests of the Members in the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nCompany.<\/p>\n<p>          &#8220;Merck Base Commitment&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n5.1(a).<\/p>\n<p>          &#8220;Negative Carry Balance&#8221; means, with respect to a Carry Member, such<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nCarry Member&#8217;s Applicable Carried Interest of the amount, if any (without<br \/>\nduplication of Portfolio Investments sold concurrently for a gain), by which (i)<br \/>\nthe sum of Merck&#8217;s share<\/p>\n<p>                                     -10-<\/p>\n<p>of the Acquisition Costs of all Portfolio Investments in which the Carry Member<br \/>\nhad a Carry Interest and that have been previously Sold, or are being Sold<br \/>\nconcurrently with the Sale for which the Negative Carry Balance is to be<br \/>\ncalculated, since the last Sale of a Portfolio Investment in which such Carry<br \/>\nMember received a distribution of Carry Interest pursuant to Section<br \/>\n10.1(b)(iii) (the &#8220;Applicable Portfolio Investments&#8221;) exceeds (ii) all amounts<br \/>\n                   &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ndistributable to Merck pursuant to Section 10.1(b)(ii) or (iii) with respect to<br \/>\nthe Applicable Portfolio Investments before reducing such amounts by the amounts<br \/>\ndistributed as Carry Distributions to the Carry Members pursuant to Section<br \/>\n10.1(b)(iii). For purposes of this definition, if a Carry Member&#8217;s Carry<br \/>\nInterest increases in accordance with the definition of Applicable Carried<br \/>\nInterest, the Negative Carry Balance of such Carry Member shall be recomputed<br \/>\nusing the new higher percentage.<\/p>\n<p>          &#8220;Net Acquisition Cost&#8221; shall mean, with respect to any Portfolio<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nInvestment, the Acquisition Cost of such Portfolio Investment reduced by the<br \/>\ncumulative amount of distributions under Section 10.1(b)(ii) with respect to<br \/>\nsuch Portfolio Investment.<\/p>\n<p>          &#8220;Net Profit&#8221; and &#8220;Net Loss&#8221; mean, respectively, for any period the<br \/>\n           &#8212;&#8212;&#8212;-       &#8212;&#8212;&#8211;<br \/>\ntaxable income and taxable loss of the Company for the period as determined for<br \/>\nfederal income tax purposes, provided that for purposes of determining Net<br \/>\nProfit and Net Loss and items of gross income, deductions and expenses and not<br \/>\nfor income tax purposes: (i) there shall be taken into account any tax exempt<br \/>\nincome of the Company; (ii) any expenditures of the Company which are described<br \/>\nin Section 705(a)(2)(B) of the Code or which are deemed to be described in<br \/>\nSection 705(a)(2)(B) of the Code pursuant to Regulations under Section 704(b) of<br \/>\nthe Code shall be treated as deductible expenses; (iii) if any Company asset has<br \/>\na Book Value which differs from its adjusted tax basis as determined for federal<br \/>\nincome tax purposes, income, gain, loss and deduction with respect to such asset<br \/>\nshall be computed based upon the asset&#8217;s Book Value rather than its adjusted tax<br \/>\nbasis in such manner as provided in the Regulations; (iv) items of gross income<br \/>\nor deduction allocated pursuant to Section 9.2(b)-(d) shall be excluded from the<br \/>\ncomputation of Net Profit and Net Loss; (v) there shall be taken into account<br \/>\nany separately stated items computed under Section 703(a) of the Code; and (vi)<br \/>\nif the Book Value of any Company asset is adjusted pursuant to clauses (ii) &#8211;<br \/>\n(iv) of the definition thereof, the amount of such adjustment shall be taken<br \/>\ninto account in the taxable year of adjustment as gain or loss from the<br \/>\ndisposition of such asset for purposes of computing Net Profit and Net Loss.<\/p>\n<p>          &#8220;Net Profit Amount&#8221; shall mean in respect of a Carry Member an amount<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nequal to the excess of (i) the aggregate amount of all distributions made to<br \/>\nMerck pursuant to Sections 10.1(b)(ii) and (iii) and the Carry Members pursuant<br \/>\nto the proviso in Section 10.1(b)(iii) in respect of all Portfolio Investments<br \/>\nin which such Carry Member has or had a Carry Interest, provided, however, that<br \/>\n                                                        &#8212;&#8212;&#8211;  &#8212;&#8212;-<br \/>\nin relation to those Portfolio Investments for which a deemed distribution under<br \/>\nSection 10.2(c) has occurred, the price <\/p>\n<p>                                     -11-<\/p>\n<p>set forth in the Bona Fide Third Party Offer will be deemed to be the amount of<br \/>\nthe distribution in respect of that Portfolio Investment for the purposes of<br \/>\nsentence (i) of this definition, over (ii) the aggregate amount of Acquisition<br \/>\nCosts contributed by Merck with respect to such Portfolio Investments.<\/p>\n<p>          &#8220;Net Sales Proceeds&#8221; means Cash payments (including any Cash received<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nby way of deferred payment pursuant to, or by amortization of, a note receivable<br \/>\nor otherwise, as and when so received) received upon the Sale of Other Fees or<br \/>\nOther Securities, net of any bona fide direct costs incurred in connection with<br \/>\nsuch sale, including, without limitation, brokers&#8217; fees, legal fees and expenses<br \/>\nand investment banking fees (but excluding any income taxes) reasonably<br \/>\nestimated to be payable as a result of any gain recognized in connection<br \/>\ntherewith.<\/p>\n<p>          &#8220;Non-Merck Members&#8221; shall have the meaning set forth in Section 16.14.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>          &#8220;Officers&#8221; shall have the meaning set forth in Section 6.12.<br \/>\n           &#8212;&#8212;&#8211;<\/p>\n<p>          &#8220;Operating Expenses&#8221; shall mean all costs and expenses relating to the<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nCompany&#8217;s activities, investments and business (to the extent not borne or<br \/>\nreimbursed by a Portfolio Company), including, without limitation, (i) all costs<br \/>\nand expenses attributable to acquiring, holding and disposing of the Company&#8217;s<br \/>\ninvestments (including, without limitation, interest on money borrowed by the<br \/>\nCompany or on behalf of the Company, legal fees and expenses, travel expenses,<br \/>\nregistration expenses and brokerage, finders&#8217;, custodial and other fees), (ii)<br \/>\nlegal, accounting, auditing, consulting and other costs and expenses directly<br \/>\nrelating to the ongoing activities of the Company (including, without<br \/>\nlimitation, travel expenses, expenses associated with the preparation of<br \/>\nfinancial statements, valuation reports, tax returns and forms K-1), (iii)<br \/>\nexpenses of the Board of Managers and Investment Committee that the Company is<br \/>\nrequired to pay, (iv) costs, expenses and liabilities of the Company (including,<br \/>\nwithout limitation, litigation and indemnification costs and expenses, judgments<br \/>\nand settlements), (v) the payment of the salaries of all of the employees of the<br \/>\nCompany (if any), (vi) rental and other office expenses of the Company and (vii)<br \/>\nall out-of-pocket fees and expenses incurred by the Company or its members,<br \/>\nofficers and employees (without duplication) whether prior to or after the date<br \/>\nhereof directly relating to investment and disposition opportunities for the<br \/>\nCompany not consummated (including, without limitation, legal, travel,<br \/>\naccounting, auditing, engineering, consulting and other fees and expenses of<br \/>\nadvisors and experts, financing commitment and investment banking fees, and<br \/>\nprinting).<\/p>\n<p>          &#8220;Organizational Expenses&#8221; shall mean all costs actually incurred in<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\norganizing the Company, including, without limitation, all fees, costs and<br \/>\nexpenses in connection with the planning, negotiation, execution and delivery of<br \/>\nthis Agreement and the organization and offering of interests in the Company<br \/>\n(including, without limitation, travel, planning, printing and attorneys&#8217; and<br \/>\naccountants&#8217; fees and expenses).<\/p>\n<p>                                     -12-<\/p>\n<p>          &#8220;Other Fees&#8221; shall have the meaning set forth in Section 8.3(a).<br \/>\n           &#8212;&#8212;&#8212;-<\/p>\n<p>          &#8220;Other Investor Members Base Commitment&#8221; shall have the meaning set<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nforth in Section 5.1<\/p>\n<p>          &#8220;Other Securities&#8221; shall have the meaning set forth in Section 8.3(b).<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>          &#8220;Partially Adjusted Capital Account&#8221; means, with respect to any Member<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nand any Fiscal Year (or period), the Capital Account of such Member at the<br \/>\nbeginning of such Fiscal Year (or period), adjusted for all contributions and<br \/>\ndistributions during such year (or period) and all special allocations pursuant<br \/>\nto Sections 9.2(b), (c), (d) and (e) with respect to such Fiscal Year (or<br \/>\nperiod), but before giving effect to any allocations of Net Profit or Net Loss<br \/>\nwith respect to such Fiscal Year (or period).<\/p>\n<p>          &#8220;Person&#8221; means any natural person, corporation, membership, trust,<br \/>\n           &#8212;&#8212;<br \/>\npartnership, limited liability company, association or other entity.<\/p>\n<p>          &#8220;Portfolio Company&#8221; shall mean any Person that is the issuer of a<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nPortfolio Investment (other than a Short-Term Investment).<\/p>\n<p>          &#8220;Portfolio Investment&#8221; shall mean an investment made by the Company,<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ndirectly or by or through an entity created for the purpose of making such<br \/>\ninvestment, in a Portfolio Company, including, without limitation, through the<br \/>\nacquisition of assets, capital stock, partnership interests, equity securities,<br \/>\nequity related securities, joint venture interests, undivided interests, leasing<br \/>\ninterests, limited liability company interests or convertible or other<br \/>\ninvestment interests, or any combination thereof, or securities or interests<br \/>\nconvertible into or exchangeable for any of the foregoing, including, without<br \/>\nlimitation, any business transaction in which the Company or an entity created<br \/>\nfor the purpose of making such investment acquires a Portfolio Company or<br \/>\ninterest therein by tender offer, takeover bid, merger, leveraged buyout, open<br \/>\nmarket purchase, private placement or otherwise and including any of the<br \/>\nforegoing received in exchange for or upon conversion of a Portfolio Investment<br \/>\nin connection with the merger or consolidation or other business combination of<br \/>\na Portfolio Company with or into another Person.<\/p>\n<p>          &#8220;Proceeds&#8221; shall have the meaning set forth in Section 10.1(b).<br \/>\n           &#8212;&#8212;&#8211;<\/p>\n<p>          &#8220;Public Float&#8221; means the aggregate Fair Market Value of the common<br \/>\n           &#8212;&#8212;&#8212;&#8212;<br \/>\nstock of an issuer held by Persons who are not Affiliates of such issuer.<\/p>\n<p>          &#8220;Purchase Date&#8221; shall have the meaning set forth in Section 8.2(g).<br \/>\n           &#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>          &#8220;Qualified IPO&#8221; means a bona fide underwritten public offering,<br \/>\n           &#8212;&#8212;&#8212;&#8212;-<br \/>\npursuant to an effective registration statement under the Securities Act of<br \/>\n1933, of the common stock of a Portfolio Company in which the underwriters<br \/>\nrepresent in writing that they are<\/p>\n<p>                                     -13-<\/p>\n<p>prepared to include in such public offering the Company&#8217;s entire interest in<br \/>\nsuch Portfolio Company.<\/p>\n<p>          &#8220;Qualifying Issuer&#8221; means any Portfolio Company whose common stock is<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ntraded on a national securities exchange or on the Nasdaq Stock Market having<br \/>\n(i) a Public Float of at least $500 million or (ii) an average daily trading<br \/>\nvolume for the 20 Business Days prior to the date Lofberg presents a Divestment<br \/>\nProposal to the Board of Managers of at least 25% of the Company&#8217;s interest in<br \/>\nsuch Portfolio Company.<\/p>\n<p>          &#8220;Quarter&#8221; means any consecutive three month period.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;Ratable Contribution Percentage&#8221; means the proportion of the total<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nobligation of the Other Investor Members to make Capital Contributions<br \/>\nattributable to each Other Investor Member expressed as a percentage which shall<br \/>\ninitially be the percentages set out in Schedule B of this Agreement but which<br \/>\nmay be amended from time to time in accordance with Section 5.5.<\/p>\n<p>          &#8220;Reg.(S)&#8221; shall mean a section of the Regulations.<br \/>\n           &#8212;&#8212;-<\/p>\n<p>          &#8220;Regulations&#8221; shall mean the Treasury regulations from time to time<br \/>\n           &#8212;&#8212;&#8212;&#8211;<br \/>\nissued pursuant to, and in effect under, the Code.<\/p>\n<p>          &#8220;Required Consents&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n8.3(c).<\/p>\n<p>          &#8220;Sale&#8221; or &#8220;Sold&#8221; means the sale, liquidation or other disposition of a<br \/>\n           &#8212;-      &#8212;-<br \/>\nPortfolio Investment for cash or the distribution in kind of a Portfolio<br \/>\nInvestment; provided that (i) if a Portfolio Investment is partially sold or<br \/>\ndistributed in kind, only the portion so sold or distributed shall be treated as<br \/>\na &#8220;Sold&#8221; Portfolio Investment and (ii) if a Portfolio Investment is exchanged<br \/>\nfor securities, the Portfolio Investment shall not be treated as a &#8220;Sold&#8221;<br \/>\nPortfolio Investment.<\/p>\n<p>          &#8220;Section 705(a)(2)(B) Expenditure&#8221; shall mean an expenditure described<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nin Section 705(a)(2)(B) of the Code which is neither deductible in computing<br \/>\ntaxable income nor properly chargeable to capital accounts and any expenditure<br \/>\nconsidered to be an expenditure described in Section 705(a)(2)(B) of the Code<br \/>\npursuant to Regulations under Section 704(b) of the Code.<\/p>\n<p>          &#8220;Short-Term Investments&#8221; shall mean: (i) negotiable instruments or<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nsecurities (whether certificated or uncertificated) which evidence (A)<br \/>\nobligations of or fully guaranteed by the United States of America, (B) time<br \/>\ndeposits in, or bankers&#8217; acceptances or certificates of deposit issued by, any<br \/>\ndepository institution or trust company organized under the laws of the United<br \/>\nStates of America or any state thereof, subject to supervision and examination<br \/>\nby United States or state banking or depository institution authorities and<br \/>\nhaving, to the knowledge of the Carry Members at the time<\/p>\n<p>                                     -14-<\/p>\n<p>such investment is made or committed, reported capital and surplus in excess of<br \/>\n$250,000,000, and (c) commercial paper having a maturity of less than 180 days<br \/>\nand having, at the time of the investment or commitment to invest therein, a<br \/>\nrating from Moody&#8217;s Investors Service, Inc. or Standard &amp; Poor&#8217;s Corporation of<br \/>\nP-1 or A-1, respectively; and (ii) demand deposits in any depository institution<br \/>\nor trust company referred to in (i)(B) above.<\/p>\n<p>          &#8220;Start Date&#8221; means, in respect of Lofberg and Cooper, the date of this<br \/>\n           &#8212;&#8212;&#8212;-<br \/>\nAgreement, and in respect of any Designated Applicable Carry Member, the date<br \/>\nsuch Designated Applicable Carry Member is designated pursuant to section 5.5 or<br \/>\nsuch other date after such designation as may be specified by the Board of<br \/>\nManagers in a resolution of the Board.<\/p>\n<p>          &#8220;Target Capital Account&#8221; means, with respect to any Member and any<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nFiscal Year (or period), an amount (which may be either a positive or a deficit<br \/>\nbalance) equal to the hypothetical distribution such Member would receive<br \/>\npursuant to clause (i) below, minus the hypothetical contribution such Member<br \/>\nwould be required to make pursuant to clause (ii), and minus the Member&#8217;s share<br \/>\nof the Company&#8217;s partnership minimum gain, and minus the Member&#8217;s share of the<br \/>\nCompany&#8217;s partner nonrecourse debt minimum gain, all computed immediately prior<br \/>\nto the hypothetical sale described in clause (i) below.<\/p>\n<p>               (i)   The hypothetical distribution to a Member at any time is<br \/>\n                     equal to the amount that would be received by such Member<br \/>\n                     if all of the Company&#8217;s assets were sold for an amount of<br \/>\n                     cash equal to their Book Values, all Company liabilities<br \/>\n                     were satisfied to the extent required by their terms<br \/>\n                     (limited, with respect to each nonrecourse liability or<br \/>\n                     &#8220;partner nonrecourse debt&#8221; (as defined in Reg.(S) 1.704-<br \/>\n                     2(b)(4)) to the Book Value of the Company assets securing<br \/>\n                     each such liability), and the net assets of the Company,<br \/>\n                     including any amount returned to the Company pursuant to<br \/>\n                     Section 12.4, were distributed in full to the Members<br \/>\n                     pursuant to Section 12.3(c) hereof upon liquidation of the<br \/>\n                     Company.<\/p>\n<p>               (ii)  The hypothetical contribution by a Member is equal to the<br \/>\n                     amount that such Member would be obligated to contribute<br \/>\n                     pursuant to Section 12.4 upon the hypothetical sale<br \/>\n                     described in clause (i) above in liquidation of the<br \/>\n                     Company.<\/p>\n<p>          &#8220;Tax Distribution&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n10.1(e).<\/p>\n<p>                                     -15-<\/p>\n<p>          &#8220;Tax Liability Amount&#8221; with respect to a Member for a Fiscal Year,<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nshall equal the product of (i) the Applicable Tax Rate, times (ii) the amount of<br \/>\nthe Company&#8217;s taxable income allocated to such Member with respect to such<br \/>\nFiscal Year.<\/p>\n<p>          &#8220;Tax Matters Member&#8221; shall have the meaning set forth in Section 13.1.<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<\/p>\n<p>          &#8220;Tax Payment Date&#8221; with respect to a Fiscal Year shall mean March 31st<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\nof the year following such Fiscal Year.<\/p>\n<p>          &#8220;Transfer&#8221; shall have the meaning set forth in Section 11.1(a).<br \/>\n           &#8212;&#8212;&#8211;    <\/p>\n<p>          &#8220;Transferring Member&#8221; shall have the meaning set forth in Section<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n8.3(c).<\/p>\n<p>          &#8220;Warrants Acquired for Cash&#8221; means warrants or options acquired for<br \/>\n           &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\ncash consideration if such warrants, after giving effect to the cash purchase<br \/>\nprice and no other consideration, were not in-the-money at the date of<br \/>\nacquisition. Warrants acquired in connection with a cash investment in other<br \/>\nsecurities (a &#8220;Unit Investment&#8221;) shall be deemed Warrants Acquired for Cash if<br \/>\n               &#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\nsuch Unit Investment is a financing transaction for a cash purchase price made<br \/>\non arm&#8217;s length terms.<\/p>\n<p>                                     -16-<\/p>\n<p>                                  Schedule A<br \/>\n                                  &#8212;&#8212;&#8212;-<\/p>\n<p>Part A &#8211; Investor Members:<\/p>\n<p>1.   Merck-Medco Managed Care, L.L.C.<br \/>\n     c\/o Merck &amp; Co. Inc.<br \/>\n     1 Merck Drive<br \/>\n     Whitehouse Station, NJ 08889<br \/>\n     Fax No.: (908) 735-1244<br \/>\n     Attention: Ken Frazier<\/p>\n<p>2.   Per G. H. Lofberg<br \/>\n     63 East 92\/nd\/ Street<br \/>\n     New York, NY 10128<br \/>\n     Fax No.: (212) 423-3034<\/p>\n<p>3.   James Cooper<br \/>\n     8 Lambert Lane<br \/>\n     Upper Saddle River, NJ 07458<br \/>\n     Fax No.: (201) 327-2671<\/p>\n<p>Part B &#8211; Carry Members:<\/p>\n<p>1.   Per G. H. Lofberg<br \/>\n     63 East 92\/nd\/ Street<br \/>\n     New York, NY 10128<br \/>\n     Fax No.: (212) 423-3043<\/p>\n<p>2.   James Cooper<br \/>\n     8 Lambert Lane<br \/>\n     Upper Saddle River, NJ 07458<br \/>\n     Fax No.: (201) 327-2671<\/p>\n<p>                                      -1-<\/p>\n<p>                                  Schedule B<br \/>\n                                  &#8212;&#8212;&#8212;-<\/p>\n<p>                             Contribution Schedule<\/p>\n<p>          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n           Lofberg                         82.75%<br \/>\n          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<br \/>\n           Cooper                          17.25%<br \/>\n          &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p>                                      -1-<\/p>\n<p>                                  Schedule C<br \/>\n                                  &#8212;&#8212;&#8212;- <\/p>\n<p>    Illustration of Distributions and Allocation of Net Profits and Losses<\/p>\n<p>                      [See attached Distribution Example]<\/p>\n<p>                                      -2-<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_stopmodifiedupdate":true,"_modified_date":"","_cloudinary_featured_overwrite":false},"corporate_contracts_companies":[8190],"corporate_contracts_industries":[9407],"corporate_contracts_types":[9573,9576],"class_list":["post-41643","corporate_contracts","type-corporate_contracts","status-publish","hentry","corporate_contracts_companies-merck---co","corporate_contracts_industries-drugs__pharma","corporate_contracts_types-formation","corporate_contracts_types-formation__llc"],"acf":[],"_links":{"self":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts\/41643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts"}],"about":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/types\/corporate_contracts"}],"wp:attachment":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/media?parent=41643"}],"wp:term":[{"taxonomy":"corporate_contracts_companies","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_companies?post=41643"},{"taxonomy":"corporate_contracts_industries","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_industries?post=41643"},{"taxonomy":"corporate_contracts_types","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_types?post=41643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}