{"id":43294,"date":"2015-09-17T11:25:58","date_gmt":"2015-09-17T16:25:58","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-legal\/contracts\/uncategorized\/asset-purchase-agreement-gilead-sciences-inc-and-osi.html"},"modified":"2015-09-17T11:25:58","modified_gmt":"2015-09-17T16:25:58","slug":"asset-purchase-agreement-gilead-sciences-inc-and-osi","status":"publish","type":"corporate_contracts","link":"https:\/\/corporate.findlaw.com\/contracts\/planning\/asset-purchase-agreement-gilead-sciences-inc-and-osi.html","title":{"rendered":"Asset Purchase Agreement &#8211; Gilead Sciences Inc. and OSI Pharmaceuticals Inc."},"content":{"rendered":"<pre><hr noshade>\n<hr noshade>\n<p align=\"CENTER\"><font size=\"2\"><b>ASSET PURCHASE AGREEMENT<\/b><\/font><\/p>\n\n<p align=\"CENTER\"><font size=\"2\">between: <\/font><\/p>\n\n<p align=\"CENTER\"><font size=\"2\"><b>GILEAD SCIENCES, INC.,<br>  <\/b><\/font><font size=\"2\">a Delaware corporation; <\/font><\/p>\n\n<p align=\"CENTER\"><font size=\"2\">and <\/font><\/p>\n\n<p align=\"CENTER\"><font size=\"2\"><b>OSI PHARMACEUTICALS, INC.<\/b><\/font><font size=\"2\">,<br> \na Delaware corporation <\/font><\/p>\n\n<hr noshade align=\"CENTER\" width=\"120\">\n<p align=\"CENTER\"><font size=\"2\">Dated \nas of November 26, 2001 <\/font><\/p>\n\n<hr noshade align=\"CENTER\" width=\"120\">\n<hr noshade>\n<hr noshade>\n<hr noshade>\n\n\n<p align=\"CENTER\"><font size=\"2\"><a name=\"page_kf1006_1_1\"> <\/a> <\/font> <font size=\"2\"><b>TABLE OF CONTENTS  <\/b><\/font><\/p>\n\n\n<\/pre>\n<table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\">1.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\">Sale and Purchase of Assets; Related Transactions<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">1<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Sale and Purchase of Assets<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">1<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Excluded Assets<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">1<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Purchase Price<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">2<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Sales and Transfer Taxes<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">2<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Allocation of Purchase Price<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">2<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Ancillary Agreements<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">3<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">1.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Closing<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">4<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n2.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nRepresentations and Warranties of Seller<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n4<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Title to Assets<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">4<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Specified Patents; Specified Know-How<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">4<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Specified Contracts; Real Property Leases; Equipment; Certain Materials<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">5<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Compliance with Legal Requirements<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">5<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Regulatory Matters<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">6<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Employee Matters<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">7<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Certain Liabilities<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">7<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.8<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Legal Proceedings<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">7<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.9<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Authority; Binding Nature of Agreement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">7<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.10<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Non-Contravention; Consents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">7<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">2.11<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Acquisition of Securities<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">8<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n3.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nRepresentations and Warranties of Purchaser<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n8<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Due Organization<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">8<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Capitalization<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">8<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">SEC Filings; Financial Statements<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">8<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Absence of Changes<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">No Undisclosed Liabilities<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">No Infringement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Compliance with Legal Requirements<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.8<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Legal Proceedings<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.9<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Authority; Binding Nature of Agreement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">9<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.10<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Non-Contravention; Consents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">10<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.11<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Shares<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">10<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">3.12<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Full Disclosure<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">10<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n4.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nPre-Closing Covenants of Seller<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n10<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">4.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Access<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">10<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">4.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Conduct of Business<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">4.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">HSR Filing<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">4.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Consents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">4.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Conditions<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n5.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nPre-Closing Covenants of Purchaser<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Access<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">HSR Filing<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">SEC Reports<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">11<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Consents; Releases<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">12<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Employment Matters<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">12<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Nasdaq Listing<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">12<\/font><\/td>\n<\/tr>\n<\/table>\n<p align=\"CENTER\"><font size=\"2\">i<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kf1006_1_2\"> <\/a><\/p>\n<table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">5.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Conditions<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">12<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n6.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nConditions Precedent to Purchaser&#8217;s Obligation to Close<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n12<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Accuracy of Representations<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">12<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Performance of Obligations<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">HSR Act<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Additional Documents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">No Restraints<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">6.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Consents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n7.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nConditions Precedent to Seller&#8217;s Obligation to Close<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Accuracy of Representations<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Performance of Obligations<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">HSR Act<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">13<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Delivery of Consideration<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Additional Documents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">No Restraints<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Nasdaq Listing<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">7.8<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Consents<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n8.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nTermination<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">8.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Right to Terminate Agreement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">14<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">8.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Termination Procedures<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">15<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">8.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Effect of Termination<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">15<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n9.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nIndemnification<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n15<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">9.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Survival of Representations; Indemnification by Seller<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">15<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">9.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Indemnification by Purchaser<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"><br \/>\n10.<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><br \/>\nMiscellaneous<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\"><br \/>\n18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.1<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Time of Essence<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.2<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">No Implied Representations<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.3<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Knowledge<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.4<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Access of Seller to Books and Records<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.5<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Governing Law<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.6<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Venue and Jurisdiction<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.7<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Notices<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">18<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.8<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Public Announcements<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.9<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Assignment<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.10<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Parties in Interest<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.11<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Severability<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.12<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Entire Agreement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.13<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Waiver<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.14<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Amendments<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">19<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.15<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Counterparts<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">20<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.16<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Interpretation of Agreement<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">20<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"4%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"7%\" align=\"RIGHT\"><font size=\"2\">10.17<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"77%\"><font size=\"2\">Further Assurances<\/font><\/td>\n<td width=\"2%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"4%\" align=\"RIGHT\"><font size=\"2\">20<\/font><\/td>\n<\/tr>\n<\/table>\n<p align=\"CENTER\"><font size=\"2\">ii<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kf1006_1_3\"> <\/a><\/p>\n<p><font size=\"2\"><b>TABLE OF EXHIBITS AND SCHEDULES  <\/b><\/font><\/p>\n<table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit A<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Certain Definitions<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit B<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Assumption Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit C<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Investor Rights Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit D<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Employee Matters Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit E<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Transition Services Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit F<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Data Transfer and Professional Services Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit G<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Nondisclosure Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit H<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Manufacturing Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit I<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of License Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit J<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of Patent Assignment Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit K<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of NCS\/NX211 Sublicense Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit L<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of GSK\/NX211 Sublicense Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit M<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of GS7904L Sublicense Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Exhibit N<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Form of GS7836 Sublicense Agreement<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\"><br \/>\nSchedule 1<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\"><br \/>\nCertain excluded assets<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 2<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Contracts to be assigned<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 3<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Patents to be assigned<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 4<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Know-how to be assigned<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 5<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Regulatory filings<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 6<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Excluded employees<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"#CCEEFF\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 7<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Consents to be obtained<\/font><\/td>\n<\/tr>\n<tr bgcolor=\"White\" valign=\"TOP\">\n<td width=\"49%\"><font size=\"2\">Schedule 8<\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"49%\"><font size=\"2\">Listed Available Employees<\/font><\/td>\n<\/tr>\n<\/table>\n<p align=\"CENTER\"><font size=\"2\">iii<\/font><\/p>\n<hr noshade>\n<p align=\"CENTER\"><font size=\"2\"><a name=\"page_kg1006_1_1\"> <\/a> <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\"><a name=\"kg1006_asset_purchase_agreement\"> <\/a><br \/>\n<a name=\"toc_kg1006_1\"> <\/a><br \/>\n<br \/><\/font><font size=\"2\"><b>ASSET PURCHASE AGREEMENT    <br \/>  <\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>THIS ASSET PURCHASE AGREEMENT<\/b><\/font><font size=\"2\"> is being entered into as of November 26, 2001, by and between: <\/font> <font size=\"2\"><b>GILEAD SCIENCES<\/b><\/font><font size=\"2\">,<br \/>\n<\/font><font size=\"2\"><b>INC<\/b><\/font><font size=\"2\">., a Delaware corporation (&#8220;Seller&#8221;); and <\/font><font size=\"2\"><b>OSI<br \/>\nPHARMACEUTICALS, INC<\/b><\/font><font size=\"2\">., a Delaware corporation (&#8220;Purchaser&#8221;). Seller and Purchaser are referred to collectively in this Agreement as the &#8220;Parties.&#8221; Certain other capitalized<br \/>\nterms used in this Agreement are defined in Exhibit A. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\"><b>RECITAL  <\/b><\/font><\/p>\n<p><font size=\"2\">    The Parties wish to provide for the purchase by Purchaser of certain assets from Seller, and to provide for certain related transactions, on the terms and<br \/>\nsubject to the conditions and other provisions set forth in this Agreement and in the Ancillary Agreements. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\"><b>AGREEMENT  <\/b><\/font><\/p>\n<p><font size=\"2\">    The Parties, intending to be legally bound, agree as follows: <\/font><\/p>\n<p><font size=\"2\"><b>1.  SALE AND PURCHASE OF ASSETS; RELATED TRANSACTIONS.  <\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.1<\/b><\/font><font size=\"2\"><b>  Sale and Purchase of Assets.<\/b><\/font><font size=\"2\">  On the terms and<br \/>\nsubject to the conditions and other provisions set forth in this Agreement and in the Ancillary Agreements, at the Closing, Seller will sell and transfer to Purchaser, and Purchaser will purchase from<br \/>\nSeller, all of the following (which, subject to Section 1.2, are referred to in this Agreement as the &#8220;Specified Assets&#8221;): <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> all of Seller&#8217;s rights and interests as of the Closing Date in and to the Specified Patents; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> all of Seller&#8217;s rights and interests as of the Closing Date in and to the Specified Know-How; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> all of Seller&#8217;s rights as of the Closing Date under the Specified Contracts; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> all items of equipment, fixtures and furnishings owned by Seller as of the Closing Date that are located and used<br \/>\nprimarily at the Boulder Facility; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> all finished product inventories, work-in-process inventories,<br \/>\nproduct-in-transit inventories and other inventories of the Specified Products, and all API inventories designated exclusively for use in the manufacture of the Specified<br \/>\nProducts, that are owned by Seller as of the Closing Date; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(f)<\/b><\/font><font size=\"2\">  all laboratory supplies, laboratory animals, cell lines, reagents and related research materials owned by Seller as<br \/>\nof the Closing Date that are located at the Boulder Facility and relate primarily to the Specified Products, to the extent freely transferable (subject to applicable contractual use restrictions); and <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(g)<\/b><\/font><font size=\"2\"> those records of Seller, as they exist on the Closing Date, that only contain preclinical and clinical data relating<br \/>\nexclusively to the Specified Products (it being understood that such records will not be subject to any restrictions on their use by Purchaser and that Seller may, subject to the provisions regarding<br \/>\nconfidentiality set forth in the Ancillary Agreements, retain copies of such records). <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.2<\/b><\/font><font size=\"2\"><b>  Excluded Assets.<\/b><\/font><font size=\"2\">  Notwithstanding anything to the<br \/>\ncontrary contained in Section 1.1, but subject to Sections 1.6(i), 1.6(j), 1.6(k) and 1.6(l), Seller will not be required to sell or transfer to Purchaser, and the Specified Assets will not be<br \/>\ndeemed to include, any of the following or any right or interest in or to any of the following: <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> subject to Section 10.17, any Specified Contract if (i) a Consent is required to be obtained from any<br \/>\nPerson in order to permit the sale or transfer to Purchaser of Seller&#8217;s rights under such Specified Contract and (ii) such Consent shall not have been obtained; <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">1<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_2\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> any cash, cash equivalents or accounts receivable; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> the premises being leased to Seller at 3035 Center Green Drive in Boulder, Colorado, or any assets located at such<br \/>\npremises; or <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> any asset identified on Schedule 1. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.3<\/b><\/font><font size=\"2\"><b>  Purchase Price.<\/b><\/font><font size=\"2\">  As consideration for the sale of<br \/>\nthe Specified Assets to Purchaser: <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> at the Closing, Purchaser will pay to Seller (without deduction or setoff of any nature), by wire transfer of<br \/>\nimmediately available funds, the sum of $130,000,000; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> at the Closing, Purchaser will issue and deliver to Seller (without deduction or setoff of any nature) the number of<br \/>\nshares (rounded to the nearest whole share) of Purchaser Common Stock determined by dividing $40,000,000 by the Closing Five-Day Average Stock Price; <\/font><font size=\"2\"><i>provided,<br \/>\nhowever<\/i><\/font><font size=\"2\">, that in no event shall the number of shares of Purchaser Common Stock to be issued to Seller at the Closing pursuant to this Section 1.3(b) be less than 760,180<br \/>\nshares or greater than 961,404 shares (the shares of Purchaser Common Stock to be issued to Seller at the Closing pursuant to this Section 1.3(b) being referred to as the &#8220;Initial Shares&#8221;); <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> at the Closing, Purchaser will assume the Assumed Liabilities by delivering to Seller an Assumption Agreement<br \/>\nsubstantially in the form of Exhibit B (the &#8220;Assumption Agreement&#8221;); <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> on the first business day after the NX211 Phase III Commencement Date, Purchaser will (without deduction or setoff<br \/>\nof any nature) do one of the following three things: (i) pay to Seller, by wire transfer of immediately available funds, the sum of $20,000,000, (ii) issue and deliver to Seller the<br \/>\nnumber of shares (rounded to the nearest whole share) of Purchaser Common Stock determined by dividing $20,000,000 by the Phase III Twenty-Day Average Stock Price or (iii) pay,<br \/>\nissue and deliver to Seller any combination of cash (paid by wire transfer of immediately available funds) and shares of Purchaser Common Stock (with each share of Purchaser Common Stock valued at the<br \/>\nPhase III Twenty-Day Average Stock Price) with an aggregate combined value equal to $20,000,000 (any shares of Purchaser Common Stock to be issued to Seller pursuant to this<br \/>\nSection 1.3(d) being referred to as &#8220;Subsequent Shares&#8221;); and <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> on the first business day after the NX211 NDA Filing Date, Purchaser will pay to Seller (without deduction or setoff<br \/>\nof any nature), by wire transfer of immediately available funds, the sum of $10,000,000. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">The<br \/>\nnumber of shares of Purchaser Common Stock to be issued pursuant to Section 1.3(b) and the number of shares of Purchaser Common Stock to be issued pursuant to Section 1.3(d) will be<br \/>\nadjusted appropriately to reflect any stock split, stock dividend, recapitalization or other similar transaction affecting the Purchaser Common Stock that is effected or has a record date on or before<br \/>\nthe date of issuance of such shares. The Parties acknowledge that Purchaser will not be assuming any liabilities of Seller other than the Assumed Liabilities, and that Seller will remain responsible<br \/>\nfor all liabilities of Seller other than the Assumed Liabilities. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.4<\/b><\/font><font size=\"2\"><b>  Sales and Transfer Taxes.<\/b><\/font><font size=\"2\">  Purchaser will bear and<br \/>\npay, and will reimburse Seller for, any sales taxes, use taxes, transfer taxes, documentary charges, recording fees, filing fees or similar taxes, charges, fees or expenses that may become payable in<br \/>\nconnection with the sale of the Specified Assets to Purchaser, the issuance and delivery of the Initial Shares and any Subsequent Shares to Seller, the assumption by Purchaser of the Assumed<br \/>\nLiabilities or any of the other transactions contemplated by this Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.5<\/b><\/font><font size=\"2\"><b>  Allocation of Purchase Price.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> The Parties will use their best efforts to agree upon an allocation of the consideration referred to in<br \/>\nSection 1.3 among the Specified Assets and, to the extent appropriate, the Ancillary <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">2<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_3\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\nAgreements (the &#8220;Allocation&#8221;) as soon as possible after the Closing Date. The Allocation will be determined in a manner consistent with this Section 1.5 and Section 1060 of the Internal<br \/>\nRevenue Code and the Treasury Regulations thereunder, and will include the agreed value of the Initial Shares and the methodology for valuing any Subsequent Shares. Purchaser will provide a proposed<br \/>\nallocation to Seller within 25 days after the Closing Date, and Seller will deliver to Purchaser a notice setting forth any proposed changes to such allocation within 15 days after the<br \/>\ndelivery of such proposed allocation to Seller, together with a reasonably detailed explanation of the reasons for such proposed changes. The Parties will negotiate in good faith to resolve any<br \/>\ndisputed items, and if the Parties are unable to agree on the Allocation within 15 days after delivery of such notice to Purchaser, then the dispute will be arbitrated by a &#8220;Big Five&#8221;<br \/>\naccounting firm mutually acceptable to the Parties, whose determination will be conclusive and binding upon the Parties for tax purposes. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> The Allocation (including the agreed value of the Initial Shares and the methodology for valuing any Subsequent<br \/>\nShares) will be conclusive and binding upon the Parties for tax purposes, and neither Party will make any statement or declaration to any taxing authority that is inconsistent with the Allocation,<br \/>\nexcept as provided below. Neither Party will take or permit any of its affiliates or representatives to take any position on any tax return, with any taxing authority or in any judicial tax proceeding<br \/>\nthat is inconsistent with the Allocation except as required by a final determination within the meaning of Section 1313(a) of the Internal Revenue Code or any equivalent provision of any<br \/>\napplicable state or local law. Each Party will promptly provide the other Party with any additional information required to complete Form 8594 if the filing of such form is required. Each Party<br \/>\nwill timely notify the other Party,<br \/>\nand will timely provide the other Party with assistance, in the event of an examination, audit or other proceeding regarding the Allocation. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.6  Ancillary Agreements.<\/b><\/font><font size=\"2\">  At the Closing, the Parties will enter into the following additional<br \/>\nagreements (the &#8220;Ancillary Agreements&#8221;): <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> an Investor Rights Agreement substantially in the form of Exhibit C (the &#8220;Investor Rights Agreement&#8221;); <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> an Employee Matters Agreement substantially in the form of Exhibit D (the &#8220;Employee Matters Agreement&#8221;); <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> a Transition Services Agreement substantially in the form of Exhibit E; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> a Data Transfer and Professional Services Agreement substantially in the form of Exhibit F; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> a Nondisclosure Agreement substantially in the form of Exhibit G; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(f)<\/b><\/font><font size=\"2\">  a Manufacturing Agreement substantially in the form of Exhibit H; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(g)<\/b><\/font><font size=\"2\"> a License Agreement substantially in the form of Exhibit I; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(h)<\/b><\/font><font size=\"2\"> a Patent Assignment Agreement substantially in the form of Exhibit J; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\">  if the NCS\/NX211 Consent shall not have been obtained, a NCS\/NX211 Sublicense Agreement substantially in the form<br \/>\nof Exhibit K; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(j)<\/b><\/font><font size=\"2\">  if the GSK\/NX211 Consent shall not have been obtained, a GSK\/NX211 Sublicense Agreement substantially in the form<br \/>\nof Exhibit L; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(k)<\/b><\/font><font size=\"2\"> if the GSK\/GS7904L Consent shall not have been obtained, a GS7904L Sublicense Agreement substantially in the form of<br \/>\nExhibit M; and <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">3<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_4\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>(l)<\/b><\/font><font size=\"2\">  if the SRI\/GS7836 Consent shall not have been obtained, a GS7836 Sublicense Agreement substantially in the form of<br \/>\nExhibit N. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>1.7<\/b><\/font><font size=\"2\"><b>  Closing.<\/b><\/font><font size=\"2\">  The closing of the purchase of the<br \/>\nSpecified Assets by Purchaser (the &#8220;Closing&#8221;) will take place at the offices of Cooley Godward llp in Colorado, at a time and on a date to be designated by Seller, which will be at least three<br \/>\nbusiness days but not more than fifteen business days after the satisfaction or waiver of the last to be satisfied or waived of the conditions set forth in Sections 6 and 7 (other than those<br \/>\nconditions that by their nature are to be satisfied at the Closing). For purposes of this Agreement, &#8220;Closing Date&#8221; means the date as of which the Closing actually takes place. <\/font><\/p>\n<p><font size=\"2\"><b>2.  REPRESENTATIONS AND WARRANTIES OF SELLER.  <\/b><\/font><\/p>\n<p><font size=\"2\">    Seller represents and warrants to Purchaser that, except as set forth in the Seller Disclosure Schedule: <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.1  Title to Assets.<\/b><\/font><font size=\"2\">  As of the Closing Date, Seller will have good and valid title to the Specified<br \/>\nAssets (<\/font><font size=\"2\"><i>provided, however,<\/i><\/font><font size=\"2\"> that Seller makes no representation or warranty as to its title to the Specified Patents except as set forth in<br \/>\nSection 2.2(a), and makes no representation or warranty as to its title to the Specified Know-How), free and clear of any liens or encumbrances, except for (i) any lien for<br \/>\ncurrent taxes not yet due and payable, (ii) liens and encumbrances referred to in the Specified Contracts and (iii) minor liens and encumbrances that have arisen in the ordinary course<br \/>\nof business and that do not materially detract from the value of the Specified Assets subject thereto. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.2  Specified Patents; Specified Know-How.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Each of the Specified Patents is owned solely by Seller, except that the patents marked by an asterisk on<br \/>\nSchedule 3 are owned jointly by Seller and North Carolina State University. Seller has made available to Purchaser copies of the Specified Patents, and has supplied to Purchaser copies of the<br \/>\npatent applications included in the Specified Patents that are not publicly available as of the date of this Agreement. To Seller&#8217;s knowledge, there are no intellectual property rights owned or<br \/>\ncontrolled by any third party necessary to make, use, sell, offer for sale and import the Specified Products, as they currently exist, other than those intellectual property rights to be transferred,<br \/>\nlicensed or sublicensed to Purchaser pursuant to this Agreement or any of the Ancillary Agreements. Seller has received no<br \/>\nwritten claim of infringement of any intellectual property rights of any Person arising out of the development, manufacture, use, sale, offer for sale or import of the Specified Products by Seller,<br \/>\nexcept for claims of infringement that have been abandoned or resolved. To Seller&#8217;s knowledge, Seller has complied with its obligation under 37 CFR \u00a71.56(a) to disclose to the United<br \/>\nStates Patent and Trademark Office, during the pendency of any United States patent application included in the Specified Patents, information known to Seller to be material to the patentability of<br \/>\nthe pending claims in such application. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Seller has not granted any Person a license that is currently in effect under any of the Specified Patents for any<br \/>\npurpose. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> None of the Specified Patents is involved in any interference or opposition proceeding, and, to Seller&#8217;s knowledge,<br \/>\nno such proceeding is being threatened with respect to any of the Specified Patents. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> Seller has disclosed trade secrets of Seller included in the Specified Know-How only to Persons that<br \/>\nhave executed written confidentiality agreements governing the use or disclosure of such trade secrets, except to the extent Seller disclosed such information in connection with making filings related<br \/>\nto any Specified Assets or Specified Products with governmental or regulatory authorities. <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">4<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_5\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> Seller has required all professional and technical employees who provided services to Seller in connection with the<br \/>\nSpecified Products, the Specified Patents or the Specified Know-How to execute agreements under which such employees were required to convey to Seller ownership of all inventions and<br \/>\ndevelopments conceived or created by them in the course of their employment with Seller. To Seller&#8217;s knowledge, none of the activities of Seller&#8217;s professional and technical employees who are<br \/>\nproviding services to Seller in connection with the Specified Products, the Specified Patents and the Specified Know-How is violating any agreement between any such employees and their<br \/>\nformer employers. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.3<\/b><\/font><font size=\"2\"><b>  Specified Contracts; Real Property Leases; Equipment; Certain<br \/>\nMaterials<\/b><\/font><font size=\"2\">.  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Seller has made available to Purchaser true and correct copies of each of the contracts identified on<br \/>\nSchedule 2. Each contract identified on Schedule 2 is valid and in full force and effect. Seller is not in material breach of any contract identified on Schedule 2, and, to<br \/>\nSeller&#8217;s knowledge, no other party to any such contract is in material breach of such contract. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> The contracts identified on Schedule 2 include the real property leases pursuant to which Seller has the<br \/>\nright to occupy the Boulder Facility. All security deposits required to be made by Seller under such real property leases have been made by Seller, and no portion of such security deposits has been<br \/>\napplied to any default by Seller under any of such real property leases. Seller has the right to occupy the Boulder Facility in accordance with the terms of such real property leases. Seller has made<br \/>\navailable to Purchaser all material information regarding the premises occupied by Seller under such real property leases. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> Seller has made available to Purchaser all material information regarding the equipment, fixtures and furnishings<br \/>\nthat are owned by Seller and located at the Boulder Facility. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> There are no laboratory supplies, laboratory animals, cell lines, reagents or related research materials owned by<br \/>\nSeller at a location other than the Boulder Facility that relate exclusively to the Specified Products. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.4  Compliance with Legal Requirements.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Seller is in substantial compliance with all Legal Requirements relating to the use of the Specified Assets. Since<br \/>\nJanuary 1, 2000, Seller has not received any written notice from any governmental body alleging any failure to comply with any Legal Requirement relating to the use of the Specified Assets and<br \/>\nthe employment of the Available Employees, except for any such notice relating to a failure to comply that has since been cured. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> To Seller&#8217;s knowledge, at all times prior to August 1, 1999, Seller was in substantial compliance with all<br \/>\nEnvironmental Laws applicable to the Specified Assets, the Boulder Facility and Seller&#8217;s operations at the Boulder Facility. Seller is, and has been at all times since August 1, 1999, in<br \/>\nsubstantial compliance with all Environmental Laws applicable to the Specified Assets, the Boulder Facility and Seller&#8217;s operations at the Boulder Facility. To Seller&#8217;s knowledge, no event has<br \/>\noccurred or condition exists or has existed which would reasonably be expected to give rise to liability on the part of Purchaser pursuant to, or to materially impair Purchaser&#8217;s compliance with, any<br \/>\nEnvironmental Law applicable to the Specified Assets and the Boulder Facility. The Boulder Facility has not been listed or, to Seller&#8217;s knowledge, proposed for listing on the National Priorities List<br \/>\nestablished by the United States Environmental Protection Agency, or any similar federal or state list. To Seller&#8217;s knowledge, no material lien has attached to any of Seller&#8217;s property at the Boulder<br \/>\nFacility pursuant to any Environmental Law. <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">5<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_6\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> There has not been any action taken by Seller, operating practice by Seller or failure by Seller to act that would<br \/>\nreasonably be expected to give rise to a material liability on the part of Purchaser as a result of: <\/font><\/p>\n<ul>\n<p><font size=\"2\">     <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\"> the handling, storage, use, presence, transportation or disposal or arranging for transportation or disposal of any<br \/>\nHazardous Substance by Seller in, on, under, near or from the Boulder Facility; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(ii)<\/b><\/font><font size=\"2\"> any emission, discharge or release of any Hazardous Substance by Seller on or from the Boulder Facility into or<br \/>\nupon the air, surface water, ground water or land; <\/font><\/p>\n<p><font size=\"2\">   <\/font><font size=\"2\"><b>(iii)<\/b><\/font><font size=\"2\"> any disposal, handling, manufacturing, processing, distribution, use, treatment or transport of any Hazardous<br \/>\nSubstances by Seller on or from the Boulder Facility; or <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(iv)<\/b><\/font><font size=\"2\"> the presence of any Hazardous Substances (including asbestos, urea formaldehyde foam installation or similar<br \/>\nsubstances contained in building materials) in or on the Boulder Facility. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> Seller holds all registrations, permits, licenses and approvals issued by or on behalf of any federal, state or<br \/>\nlocal government body that are required pursuant to any Environmental Laws for the occupancy of and the conduct of business at the Boulder Facility and the ownership of the Specified Assets<br \/>\n(&#8220;Environmental Permits&#8221;), except where the failure to hold such Environmental Permits would not have a material adverse effect on the value of the Specified Assets taken as a whole. Any such<br \/>\nEnvironmental Permits held by Seller are currently in full force and effect. Seller is in substantial compliance with all terms and conditions of such Environmental Permits, and with all other<br \/>\napplicable limitations, restrictions, conditions, standards, prohibitions, requirements, obligations, schedules and timetables contained in Environmental Laws. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> To Seller&#8217;s knowledge, no underground storage tanks or surface impoundments exist at the Boulder Facility. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(f)<\/b><\/font><font size=\"2\">  Seller has not, either expressly or by operation of law, assumed or undertaken any liability or corrective,<br \/>\ninvestigatory or remedial obligation of any other Person relating to any Environmental Laws that would reasonably be expected to result in a material liability to Purchaser. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(g)<\/b><\/font><font size=\"2\"> Seller has made available to Purchaser copies of any environmental reports, audits, permits, licenses, registrations<br \/>\nand other environmental, health or safety documents relating to the Specified Assets and the Boulder Facility that are in Seller&#8217;s possession or control. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.5  Regulatory Matters.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> The Specified Regulatory Filings are current and in full force and effect and include all regulatory filings and<br \/>\ngovernmental registrations made by or issued to Seller that relate specifically to the Specified Products. Seller has made available to Purchaser copies of all governmental correspondence (including<br \/>\ncopies of official notices, citations or decisions) in Seller&#8217;s files relating to the Specified Regulatory Filings, except for governmental correspondence relating to the manufacture of Specified<br \/>\nProducts. To Seller&#8217;s knowledge, in the course of the clinical development of the Specified Products, Seller has not used any employee or consultant who (at the time such employee or consultant<br \/>\nprovided services to Seller with respect to the Specified Products) was debarred by the FDA or the subject of pending disbarment proceedings by the FDA. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Seller is in substantial compliance with the laws applicable to the development, manufacture, labeling, testing and<br \/>\ninspection of the Specified Products (at the Boulder Facility and otherwise) and the operation of manufacturing facilities used to manufacture the Specified Products, and with all applicable<br \/>\nregulations, policies and procedures promulgated by the FDA <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">6<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_7\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\nwith respect thereto. Seller has received no written notice that any recalls, field notifications or seizures have been ordered or, to Seller&#8217;s knowledge, threatened by any governmental body with<br \/>\nrespect to any of the Specified Products. Seller has not received a warning letter or other similar written notice from the FDA regarding the Specified Products or the manufacturing facilities used to<br \/>\nmanufacture the Specified Products, except for written notices regarding matters that have since been cured, corrected or resolved. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.6<\/b><\/font><font size=\"2\"><b>  Employee Matters.<\/b><\/font><font size=\"2\">  Seller has made available to<br \/>\nPurchaser (except to the extent prohibited under applicable Legal Requirements) accurate information with respect to the employment of, the job responsibilities of, the compensation payable by Seller<br \/>\nto, the stock options of Seller held by and the employee benefits being provided to each of the Available Employees. As of the date of this Agreement, there are approximately 147 employees of Seller<br \/>\nbased at the Boulder Facility. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.7  Certain Liabilities.<\/b><\/font><font size=\"2\">  As of the date of this Agreement, Seller has no material liabilities relating<br \/>\nto the Specified Assets, the Specified Products or the Available Employees other than (i) liabilities under or relating to the contracts and other instruments identified on Schedule 2,<br \/>\n(ii) liabilities incurred in the ordinary course of business or consistent with past practices, (iii) liabilities referred to in, or relating to matters referred to in, the Seller<br \/>\nDisclosure Schedule, (iv) liabilities under applicable Legal Requirements, (v) liabilities referred to in the written materials made available by Seller to Purchaser during the period<br \/>\nfrom September 20, 2001 through the date of this Agreement and (vi) liabilities otherwise made known to or discovered by Purchaser in the course of Purchaser&#8217;s investigation of the<br \/>\nSpecified Assets, the Specified Products, the Available Employees and the operations conducted at the Boulder Facility during the period from September 20, 2001 through the date of this<br \/>\nAgreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.8  Legal Proceedings.<\/b><\/font><font size=\"2\">  There is no lawsuit or other legal proceeding pending or, to Seller&#8217;s knowledge,<br \/>\nbeing threatened against Seller as of the date of this Agreement that involves the Specified Assets and would reasonably be expected to result in a judgment having a material adverse effect on the<br \/>\nvalue of the Specified Assets taken as a whole. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.9  Authority; Binding Nature of Agreement.<\/b><\/font><font size=\"2\">  Seller has all necessary corporate power and authority to<br \/>\nexecute and deliver this Agreement and the Ancillary Agreements and to perform its obligations under this Agreement and the Ancillary Agreements; and the execution, delivery and performance by Seller<br \/>\nof this Agreement and the Ancillary Agreements have been duly authorized by all necessary action on the part of Seller and its board of directors. Seller has provided to Purchaser a copy of the<br \/>\nresolutions adopted by the board of directors of Seller authorizing the execution, delivery and performance by Seller of this Agreement and the Ancillary Agreements. No vote of the holders of Seller&#8217;s<br \/>\ncommon stock is required to authorize the transactions contemplated by this Agreement. This Agreement constitutes, and, upon execution thereof, each of the Ancillary Agreements will constitute, the<br \/>\nvalid and binding obligation of Seller, enforceable against Seller in accordance with its terms, subject to (i) laws of general application relating to bankruptcy, insolvency and the relief of<br \/>\ndebtors and (ii) rules of law governing specific performance, injunctive relief and other equitable remedies. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>2.10  Non-Contravention; Consents.<\/b><\/font><font size=\"2\">  Assuming the Consents referred to in Part 2.10 of<br \/>\nthe Seller Disclosure Schedule are obtained, the execution and delivery by Seller of this Agreement and the Ancillary Agreements and the sale of the Specified Assets by Seller to Purchaser will not:<br \/>\n(a) materially contravene or result in a material violation or breach of any Legal Requirement applicable to the Specified Assets or any Specified Contract; or (b) result in the<br \/>\nimposition of any lien or encumbrance upon any of the Specified Assets (except for minor liens that will not materially detract from the value of the Specified Assets taken as a whole). Except as set<br \/>\nforth in Part 2.10 of the Seller Disclosure Schedule, Seller is not required to obtain any Consent from any Person, under any material Specified Contract, at or prior to the Closing in<br \/>\nconnection with the execution and delivery of this Agreement or the Ancillary Agreements or the sale of the Specified Assets to Purchaser. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">7<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_8\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>2.11  Acquisition of Securities.<\/b><\/font><font size=\"2\">  Seller will acquire the Initial Shares and any Subsequent Shares for<br \/>\nits own account and not with a view to the public distribution thereof. Seller acknowledges that additional representations and warranties with respect to the acquisition of the Initial Shares and any<br \/>\nSubsequent Shares are set forth in the Investor Rights Agreement. <\/font><\/p>\n<p><font size=\"2\"><b>3.  REPRESENTATIONS AND WARRANTIES OF PURCHASER<\/b><\/font><font size=\"2\">. <\/font><\/p>\n<p><font size=\"2\">    Purchaser<br \/>\nrepresents and warrants to Seller as follows: <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.1<\/b><\/font><font size=\"2\"><b>  Due Organization.<\/b><\/font><font size=\"2\">  Purchaser is a corporation duly<br \/>\norganized, validly existing and in good standing under the laws of the State of Delaware. Each material subsidiary of Purchaser is a corporation duly organized, validly existing and in good standing<br \/>\nunder the laws of the jurisdiction in which it was organized, except where the failure to be in good standing would not reasonably be expected to have a material adverse effect on in the business,<br \/>\nassets (tangible or intangible), liabilities or operations of Purchaser and its subsidiaries (collectively, the &#8220;Purchaser Corporations.&#8221;) <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.2<\/b><\/font><font size=\"2\"><b>  Capitalization.<\/b><\/font><font size=\"2\">  The authorized capital stock of<br \/>\nPurchaser consists of 200,000,000 shares of Purchaser Common Stock and 5,000,000 shares of preferred stock. As of November 16, 2001, 35,072,529 shares of Purchaser Common Stock were issued and<br \/>\noutstanding. No shares of preferred stock of Purchaser have been issued or are outstanding. All of the outstanding shares of Purchaser Common Stock have been duly authorized and validly issued, and<br \/>\nare fully paid and nonassessable. No Person holds any preemptive or similar right with respect to any future issuance of Purchaser Common Stock. As of November 16, 2001, 3,745,690 shares of<br \/>\nPurchaser Common Stock were reserved for future issuance pursuant to outstanding stock options granted to employees under Purchaser&#8217;s stock option plans. Except for stock options and purchase rights<br \/>\noutstanding under Purchaser&#8217;s employee stock option and employee stock purchase plans, and except as set forth in the Purchaser Disclosure Schedule, there are (i) no outstanding options, calls,<br \/>\nwarrants or rights (whether or not currently exercisable) to acquire from any of the Purchaser Corporations any shares of the capital stock or other securities of any of the Purchaser Corporations,<br \/>\n(ii) no outstanding securities, instruments or obligations that are or may become convertible into or exchangeable for any shares of the capital stock or other securities of any of the<br \/>\nPurchaser Corporations, (iii) no agreements, commitments or arrangements to which any of the Purchaser Corporations is a party (other than Purchaser&#8217;s employee benefit plans) under which any of<br \/>\nthe Purchaser Corporations is or may become obligated to issue any shares of its capital stock or other securities and (iv) no stockholder agreements, voting agreements or other similar<br \/>\nagreements with respect to Purchaser Common Stock to which Purchaser is a party or, to Purchaser&#8217;s knowledge, between or among any of Purchaser&#8217;s stockholders. Part 3.2 of the Purchaser<br \/>\nDisclosure Schedule describes all registration rights and similar rights possessed by holders of Purchaser Common Stock and other securities of Purchaser. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.3<\/b><\/font><font size=\"2\"><b>  SEC Filings; Financial Statements.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Copies of all reports, registration statements, proxy statements and other documents filed by Purchaser with the SEC<br \/>\nsince January 1, 2000 (the &#8220;Purchaser SEC Documents&#8221;) have been made available to Seller for its review. All reports, statements and other documents required to have been filed by Purchaser<br \/>\nwith the SEC have been so filed on a timely basis. As of the time it was filed with the SEC (or, if amended or superseded by a filing prior to the date of this Agreement, then on the date of such<br \/>\nfiling): (i) each of the Purchaser SEC Documents complied in all material respects with the applicable requirements of the Securities Act or the Exchange Act (as the case may be); and<br \/>\n(ii) none of the Purchaser SEC Documents contained any untrue statement of a material fact or omitted to state<br \/>\na material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">8<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_9\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> The consolidated financial statements contained in the Purchaser SEC Documents: (i) complied as to form in<br \/>\nall material respects with the published rules and regulations of the SEC applicable thereto; (ii) were prepared in accordance with generally accepted accounting principles applied on a<br \/>\nconsistent basis throughout the periods covered (except as may be indicated in the notes to such financial statements and, in the case of unaudited statements, as permitted by<br \/>\nForm 10-Q of the SEC, and except that unaudited financial statements may not contain footnotes and are subject to normal and recurring year-end audit adjustments which<br \/>\nwill not, individually or in the aggregate, be material in amount); and (iii) fairly present the consolidated financial position of the Purchaser Corporations as of the respective dates thereof<br \/>\nand the consolidated results of operations and cash flows of the Purchaser Corporations for the periods covered thereby. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.4<\/b><\/font><font size=\"2\"><b>  Absence of Changes.<\/b><\/font><font size=\"2\">  Since June 30, 2001,<br \/>\nthere has not been any material adverse change in the business, condition, capitalization, assets (tangible or intangible), liabilities, operations, financial performance or prospects of the Purchaser<br \/>\nCorporations, and no event has occurred or circumstance exists that could reasonably be expected to result in such a material adverse change. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.5<\/b><\/font><font size=\"2\"><b>  No Undisclosed Liabilities.<\/b><\/font><font size=\"2\">  None of the Purchaser<br \/>\nCorporations has any material accrued, contingent or other liabilities of any nature, except for (i) liabilities reflected in the consolidated balance sheet of the Purchaser Corporations as of<br \/>\nJune 30, 2001, contained in Purchaser&#8217;s Report on Form 10-Q as filed with the SEC for the quarter ended June 30, 2001, and (ii) liabilities incurred by the<br \/>\nPurchaser Corporations in the ordinary course of business since June 30, 2001. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.6<\/b><\/font><font size=\"2\"><b>  No Infringement.<\/b><\/font><font size=\"2\">  Each of the Purchaser Corporations<br \/>\npossesses all intellectual property rights required to conduct its business as now conducted, except to the extent the failure to possess such rights would not have a material adverse effect on the<br \/>\nbusiness, assets (tangible or intangible), liabilities or operations of the Purchaser Corporations. None of the Purchaser Corporations has received any notice of, or has any knowledge of, any asserted<br \/>\ninfringement of third party intellectual property rights. No event has occurred which, to Purchaser&#8217;s knowledge, permits, or after notice or lapse of time or both would permit, the revocation or<br \/>\ntermination of any of the intellectual property rights of any of the Purchaser Corporations. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.7<\/b><\/font><font size=\"2\"><b>  Compliance with Legal Requirements.<\/b><\/font><font size=\"2\">  Each of the<br \/>\nPurchaser Corporations is in substantial compliance with all applicable Legal Requirements. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.8<\/b><\/font><font size=\"2\"><b>  Legal Proceedings.<\/b><\/font><font size=\"2\">  Except as disclosed in the<br \/>\nPurchaser SEC Documents filed with the SEC before the date of this Agreement, there is no material pending or, to Purchaser&#8217;s knowledge, threatened lawsuit or other legal proceeding that involves any<br \/>\nof the Purchaser Corporations or any of the assets owned or used by any of the Purchaser Corporations. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.9<\/b><\/font><font size=\"2\"><b>  Authority; Binding Nature of Agreement.<\/b><\/font><font size=\"2\">  Purchaser<br \/>\nhas all necessary power and authority to execute and deliver this Agreement, the Assumption Agreement and the Ancillary Agreements, and to perform its obligations hereunder (including its obligations<br \/>\nrelating to the issuance and delivery of the Initial Shares and any Subsequent Shares) and thereunder; and the execution, delivery and performance by Purchaser of this Agreement, the Assumption<br \/>\nAgreement and the Ancillary Agreements have been duly authorized by all necessary action on the part of Purchaser and its board of directors. Purchaser has provided to Seller a copy of the resolutions<br \/>\nof the board of directors of Purchaser authorizing the execution, delivery and performance by Purchaser of this Agreement, the Assumption Agreement and the Ancillary Agreements. No vote of the holders<br \/>\nof Purchaser Common Stock is required to authorize the purchase by Purchaser of the Specified Assets, the issuance by Purchaser of the Initial Shares or any Subsequent Shares or any of the other<br \/>\ntransactions contemplated by this Agreement. This Agreement constitutes, and, upon execution thereof, each of the Assumption Agreement and the Ancillary Agreements will constitute, the valid and<br \/>\nbinding obligation of Purchaser, enforceable against Purchaser in accordance with its terms, subject to (i) laws of general application relating to bankruptcy, <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">9<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kg1006_1_10\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\ninsolvency and the relief of debtors, and (ii) rules of law governing specific performance, injunctive relief and other equitable remedies. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.10<\/b><\/font><font size=\"2\"><b>  Non-Contravention; Consents.<\/b><\/font><font size=\"2\">  Neither<br \/>\nthe execution, delivery or performance of this Agreement, the Assumption Agreement or any of the Ancillary Agreements, nor the consummation of any of the transactions contemplated by this Agreement<br \/>\n(including the issuance and delivery of the Initial Shares and any Subsequent Shares), the Assumption Agreement or any of the Ancillary Agreements, will (a) conflict with or result in any<br \/>\nviolation of any provision of the certificate of incorporation, bylaws or other charter or organizational documents of any of the Purchaser Corporations, (b) result in a breach or default by<br \/>\nany of the Purchaser Corporations under any material contract to which any of the Purchaser Corporations is a party, (c) result in a violation of any Legal Requirement or order to which any of<br \/>\nthe Purchaser Corporations is subject or (d) result in the creation of a lien or encumbrance on any material asset of any of the Purchaser Corporations. Purchaser is not and will not be<br \/>\nrequired to obtain any Consent from any Person in connection with the execution, delivery or performance of this Agreement, the Assumption Agreement or any of the Ancillary Agreements or the<br \/>\nconsummation of any of the transactions contemplated hereby or thereby. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.11<\/b><\/font><font size=\"2\"><b>  Shares.<\/b><\/font><font size=\"2\">  The Initial Shares and any Subsequent<br \/>\nShares will, when issued, be validly issued, fully paid and nonassessable. The issuance of the Initial Shares and any Subsequent Shares is and will be exempt from the registration provisions of the<br \/>\nSecurities Act and the registration and qualification provisions of all applicable state securities laws. All notices and filings required to be made under state securities laws in connection with the<br \/>\noffer, issuance and delivery of the Initial Shares and any Subsequent Shares have been or will be given and made by Purchaser on a reasonably timely basis. The Purchaser<br \/>\nCommon Stock is registered pursuant to Section 12(g) of the Exchange Act and is listed on The Nasdaq National Market, and Purchaser has taken no action that may have the effect of terminating<br \/>\nthe registration of the Purchaser Common Stock under the Exchange Act or delisting the Purchaser Common Stock from The Nasdaq National Market. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>3.12<\/b><\/font><font size=\"2\"><b>  Full Disclosure.<\/b><\/font><font size=\"2\">  None of this Agreement, the<br \/>\nPurchaser Disclosure Schedule, the certificate to be delivered pursuant to Section 7.5(b)(i), the Assumption Agreement and the Ancillary Agreements (i) contains or will contain any<br \/>\nuntrue statement of fact or (ii) omits or will omit to state any fact necessary to make any of the representations, warranties or other statements or information contained herein or therein not<br \/>\nmisleading. <\/font><\/p>\n<p><font size=\"2\"><b>4.  PRE-CLOSING COVENANTS OF SELLER.<\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>4.1  Access.<\/b><\/font><font size=\"2\">  Subject to the provisions of the Confidentiality Agreements and to applicable Legal<br \/>\nRequirements, during the period from the date of this Agreement through the Closing Date (the &#8220;Pre-Closing Period&#8221;), Seller will, after receiving reasonable advance notice from Purchaser,<br \/>\ngive Purchaser reasonable access (during normal business hours) to the Boulder Facility and to Seller&#8217;s books and records relating to the Specified Assets and relating to those Available Employees who<br \/>\nconsent in writing to such access (the &#8220;Consenting Employees&#8221;), and will provide Purchaser with such information regarding the Specified Assets, the Consenting Employees and any other appropriate<br \/>\nmatters germane to the subject matter of this Agreement and the Ancillary Agreements as Purchaser may reasonably request, for the sole purposes of enabling Purchaser (i) to further investigate,<br \/>\nat Purchaser&#8217;s sole expense, the Specified Assets, the Consenting Employees and any other appropriate matters germane to the subject matter of this Agreement and the Ancillary Agreements and<br \/>\n(ii) to verify the accuracy of the representations and warranties set forth in Section 2; <\/font><font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that except as provided in<br \/>\nSection 5.5, Purchaser will not (without Seller&#8217;s approval, which will not be unreasonably withheld) contact or otherwise communicate with any of the Available<br \/>\nEmployees<\/font><font size=\"2\"><b>.<\/b><\/font><font size=\"2\"> To the extent requested by Purchaser, Seller will arrange to permit Purchaser to conduct interviews of any of the Available Employees during<br \/>\nthe Pre-Closing Period. Seller will request the consent of the Available Employees to the disclosure of their respective personnel files to Purchaser. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">10<\/font><\/p>\n<hr noshade>\n<p><font size=\"2\"><a name=\"page_ki1006_1_11\"> <\/a><br \/>\n    <\/font><font size=\"2\"><b>4.2  Conduct of Business.<\/b><\/font><font size=\"2\">  Except (i) as contemplated or permitted by this Agreement or the Seller<br \/>\nDisclosure Schedule, (ii) as contemplated by any of the Ancillary Agreements, (iii) as may be necessary to carry out any of the transactions contemplated by this Agreement or the<br \/>\nAncillary Agreements, (iv) as may be necessary to facilitate compliance with any Legal Requirement or the requirements of any Specified Contract or (v) as approved by Purchaser, during<br \/>\nthe Pre-Closing Period: <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Seller will (i) conduct its operations at the Boulder Facility in the ordinary course and consistent with its<br \/>\npast practices, to the extent such operations relate to the Specified Assets, and (ii) use commercially reasonable efforts to maintain good relations with the Available Employees and the<br \/>\nparties to the Specified Contracts; and <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Seller will not (i) license or dispose of any material Specified Assets, (ii) prematurely terminate or<br \/>\nmaterially amend, grant a sublicense under or assign any of the Specified Contracts, (iii) commit a material breach of any Specified Contract entered into after the date of this Agreement,<br \/>\n(iv) make any material changes to the compensation or benefits provided by Seller to the Available Employees or (v) enter into any employment, bonus or severance agreement with any of<br \/>\nthe Available Employees. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">If<br \/>\nSeller requests Purchaser&#8217;s approval of a proposed action that would result in a breach by Seller of this Section 4.2, Purchaser will respond promptly to Seller&#8217;s request and will not<br \/>\nunreasonably withhold its approval of the proposed action. All references in this Section 4.2 to the &#8220;Available Employees&#8221; will be deemed to refer instead only to the &#8220;Specified Employees&#8221; at<br \/>\nsuch time as the Specified Employees are identified by Purchaser pursuant to Section 5.5. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>4.3  HSR Filing.<\/b><\/font><font size=\"2\">  As promptly as possible after the date of this Agreement, Seller will file the<br \/>\nnotification form required to be filed on behalf of Seller under the HSR Act with respect to the transactions contemplated by this Agreement, and will request early termination of the applicable<br \/>\nwaiting period. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>4.4  Consents.<\/b><\/font><font size=\"2\">  Seller will use commercially reasonable efforts during the Pre-Closing Period<br \/>\nto obtain the Consents identified in Part 2.10 of the Seller Disclosure Schedule (including the NCS\/NX211 Consent, the GSK\/NX211 Consent, the GSK\/GS7904L Consent, the SRI\/GS7836 Consent and the<br \/>\nConsents identified on Schedule 7). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>4.5  Conditions.<\/b><\/font><font size=\"2\">  Seller will use commercially reasonable efforts (i) to cause the conditions set<br \/>\nforth in Section 6 to be satisfied on a timely basis and (ii) otherwise to cause the Closing to take place as soon as reasonably practicable. <\/font><\/p>\n<p><font size=\"2\"><b>5.  PRE-CLOSING COVENANTS OF PURCHASER.  <\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.1<\/b><\/font><font size=\"2\"><b>  Access.<\/b><\/font><font size=\"2\">  Subject to the provisions of the<br \/>\nConfidentiality Agreements, during the Pre-Closing Period, Purchaser will, after receiving reasonable advance notice from Seller, give Seller reasonable access (during normal business<br \/>\nhours) to the Purchaser Corporations&#8217; facilities, books and records, and will provide Seller with such information as Seller may reasonably request, for the sole purposes of enabling Seller<br \/>\n(i) to further investigate, at Seller&#8217;s sole expense, the business, condition, capitalization, assets, liabilities, operations, financial performance and prospects of each of the Purchaser<br \/>\nCorporations and (ii) to verify the accuracy of the representations and warranties set forth in Section 3. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.2<\/b><\/font><font size=\"2\"><b>  HSR Filing.<\/b><\/font><font size=\"2\">  As promptly as possible after the date<br \/>\nof this Agreement, Purchaser will file the notification form required to be filed on behalf of Purchaser under the HSR Act with respect to the transactions contemplated by this Agreement, and will<br \/>\nrequest early termination of the applicable waiting period. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.3<\/b><\/font><font size=\"2\"><b>  SEC Reports.<\/b><\/font><font size=\"2\">  Purchaser will (i) promptly<br \/>\ndeliver to Seller a copy of each report or other document filed with the SEC on behalf of Purchaser during the Pre-Closing Period and (ii) take all <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">11<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_12\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\nactions reasonably necessary to ensure that Purchaser is eligible to use SEC Form S-3 (under general instruction I.A to SEC Form S-3) from and after the Closing. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.4<\/b><\/font><font size=\"2\"><b>  Consents; Releases.<\/b><\/font><font size=\"2\">  Purchaser will cooperate with<br \/>\nSeller, and will provide Seller with such assistance as Seller may reasonably request, for the purpose of (i) attempting to obtain the Consents identified in Part 2.10 of the Seller<br \/>\nDisclosure Schedule and (ii) arranging for Seller to be released and discharged from its obligations and other liabilities under the Specified Contracts. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.5<\/b><\/font><font size=\"2\"><b>  Employment Matters.<\/b><\/font><font size=\"2\">  Within fourteen days after the<br \/>\ndate of this Agreement, Purchaser will provide to Seller a list identifying at least 105 of the Available Employees (the employees identified on such list being referred to in this Agreement as the<br \/>\n&#8220;Specified Employees&#8221;), it being understood that at least 105 of the Specified Employees must be based at the Boulder Facility. Prior to the Closing, on a date mutually agreed by the Parties,<br \/>\nPurchaser will extend to each Specified Employee an individualized written offer of employment that, if accepted, would contemplate that such Specified Employee would commence his or her employment<br \/>\nwith Purchaser on the later of January 1, 2002 or the day after the Closing Date and would provide such Specified Employee with compensation, benefits and terms of<br \/>\nemployment (including terms relating to job responsibilities) that in the aggregate are substantially as favorable to such Specified Employee as the compensation, benefits and terms of employment<br \/>\nprovided by Seller to such Specified Employee immediately prior to the Closing. Each such written offer of employment will include the terms set forth in Sections 1.1, 2.1, 2.2, 3.1, 3.2 and 4 of the<br \/>\nEmployee Matters Agreement to the extent such terms relate to the Specified Employee to whom such offer is extended. The offers made to the Specified Employees who are based at the Boulder Facility<br \/>\nwill specify a job location at the Boulder Facility. On the later of January 1, 2002 or the day after the Closing Date, Purchaser will hire each Specified Employee who accepts the written offer<br \/>\nof employment extended to such Specified Employee by Purchaser (it being understood that, except as otherwise provided in any individual employment agreement between Purchaser and a Specified<br \/>\nEmployee, Purchaser will not be obligated to maintain the employment of or the compensation or employee benefits provided to such Specified Employee for any specified period thereafter). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.6<\/b><\/font><font size=\"2\"><b>  Nasdaq Listing.<\/b><\/font><font size=\"2\">  Purchaser will use commercially<br \/>\nreasonable efforts to ensure that the Initial Shares are listed and available for quotation on The Nasdaq National Market as of the Closing Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>5.7<\/b><\/font><font size=\"2\"><b>  Conditions.<\/b><\/font><font size=\"2\">  Purchaser will use commercially<br \/>\nreasonable efforts (i) to cause the conditions set forth in Section 7 to be satisfied on a timely basis and (ii) otherwise to cause the Closing to take place as soon as reasonably<br \/>\npracticable. <\/font><\/p>\n<p><font size=\"2\"><b>6.  CONDITIONS PRECEDENT TO PURCHASER&#8217;S OBLIGATION TO CLOSE.<\/b><\/font><\/p>\n<p><font size=\"2\">    Purchaser&#8217;s<br \/>\nobligation to purchase the Specified Assets and to take the other actions required to be taken by Purchaser at the Closing is subject to the satisfaction, at or prior to<br \/>\nthe Closing, of each of the following conditions (any of which may be waived by Purchaser, in whole or in part, in writing): <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>6.1<\/b><\/font><font size=\"2\"><b>  Accuracy of Representations.<\/b><\/font><font size=\"2\">  Those representations<br \/>\nand warranties of Seller set forth in Section 2 that refer specifically to and are made as of the date of this Agreement shall have been accurate as of the date of this Agreement, and all other<br \/>\nrepresentations and warranties of Seller set forth in Section 2 (and any representations and warranties of Seller set forth in the Ancillary Agreements) shall be accurate as of the Closing Date<br \/>\nas if made on and as of the Closing Date; <\/font><font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that, for purposes of this Section 6.1, any inaccuracies in the representations and<br \/>\nwarranties of Seller will be disregarded unless all such inaccuracies, considered collectively, have a material adverse effect on the value of the Specified Assets taken as a whole. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">12<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_13\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>6.2<\/b><\/font><font size=\"2\"><b>  Performance of Covenants.<\/b><\/font><font size=\"2\">  Seller shall have<br \/>\nperformed, in all material respects, all covenants required by this Agreement and the Ancillary Agreements to be performed by Seller on or before the Closing Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>6.3<\/b><\/font><font size=\"2\"><b>  HSR Act.<\/b><\/font><font size=\"2\">  The waiting period applicable to the<br \/>\nconsummation of the transactions contemplated by this Agreement under the HSR Act shall have expired or been terminated. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>6.4<\/b><\/font><font size=\"2\"><b>  Additional Documents.<\/b><\/font><font size=\"2\">  Each of the Ancillary<br \/>\nAgreements shall have been executed on behalf of Seller and delivered to Purchaser, and each of the following additional documents shall have been delivered to Purchaser: <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> a certificate, executed by an executive officer of Seller, confirming that, to the actual knowledge of such<br \/>\nexecutive officer, the conditions set forth in Sections 6.1 and 6.2 have been satisfied; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> such bills of sale, assignments and other instruments as Seller may be required to execute in order to evidence and<br \/>\neffectuate the transfer of the Specified Assets to Purchaser; and <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> such good standing certificates and other similar documents as Purchaser may reasonably request to ensure that the<br \/>\nactions required to be taken by Seller at the Closing have been properly authorized. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>6.5<\/b><\/font><font size=\"2\"><b>  No Restraints.<\/b><\/font><font size=\"2\">  No injunction or other order<br \/>\npreventing the consummation of the transactions contemplated by this Agreement shall have been issued since the date of this Agreement by any United States federal or state court of competent<br \/>\njurisdiction and shall remain in effect; and no United States federal or state Legal Requirement that makes consummation of the transactions contemplated by this Agreement illegal shall have been<br \/>\nenacted or adopted since the date of this Agreement and shall remain in effect. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>6.6<\/b><\/font><font size=\"2\"><b>  Consents.<\/b><\/font><font size=\"2\">  The Consents identified on<br \/>\nSchedule 7 shall have been obtained. <\/font><\/p>\n<p><font size=\"2\"><b>7.  CONDITIONS PRECEDENT TO SELLER&#8217;S OBLIGATION TO CLOSE.<\/b><\/font><\/p>\n<p><font size=\"2\">    Seller&#8217;s<br \/>\nobligation to sell and transfer the Specified Assets to Purchaser and to take the other actions required to be taken by Seller at the Closing is subject to the satisfaction,<br \/>\nat or prior to the Closing, of each of the following conditions (any of which may be waived by Seller, in whole or in part, in writing): <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.1<\/b><\/font><font size=\"2\"><b>  Accuracy of Representations.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> The representations and warranties set forth in Section 3.2 shall be accurate in all material respects as of<br \/>\nthe Closing Date as if made on and as of the Closing Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> All other representations and warranties of Purchaser set forth in Section 3 (and any representations and<br \/>\nwarranties of Purchaser set forth in the Ancillary Agreements) shall be accurate as of the Closing Date as if made on and as of the Closing Date; <\/font><font size=\"2\"><i>provided,<br \/>\nhowever<\/i><\/font><font size=\"2\">, that, for purposes of this Section 7.1(b), any inaccuracies in the representations and warranties of Purchaser will be disregarded unless all such inaccuracies,<br \/>\nconsidered collectively, have a material adverse effect on the business, assets (tangible or intangible), liabilities or operations of the Purchaser Corporations. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.2<\/b><\/font><font size=\"2\"><b>  Performance of Covenants.<\/b><\/font><font size=\"2\">  Purchaser shall have<br \/>\nperformed, in all material respects, all covenants required by this Agreement and by the Ancillary Agreements to be performed by Purchaser on or before the Closing Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.3<\/b><\/font><font size=\"2\"><b>  HSR Act.<\/b><\/font><font size=\"2\">  The waiting period applicable to the<br \/>\nconsummation of the transactions contemplated by this Agreement under the HSR Act shall have expired or been terminated. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">13<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_14\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>7.4<\/b><\/font><font size=\"2\"><b>  Delivery of Consideration.<\/b><\/font><font size=\"2\">  Seller shall have<br \/>\nreceived the cash payment referred to in Section 1.3(a); and the Initial Shares shall have been duly issued and delivered by Purchaser to Seller. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.5<\/b><\/font><font size=\"2\"><b>  Additional Documents.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Seller shall have received an opinion letter from Saul Ewing LLP, dated as of the Closing Date and reasonably<br \/>\nsatisfactory to Seller, in the form customarily delivered in a private placement of shares by a publicly traded corporation. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Each of the Ancillary Agreements and the Assumption Agreement shall have been executed on behalf of Purchaser and<br \/>\ndelivered to Seller, and each of the following additional documents shall have been delivered to Seller: <\/font><\/p>\n<ul>\n<dl compact>\n<dt><font size=\"2\"><b>(i)<\/b><\/font><\/dt>\n<dd><font size=\"2\">a certificate, executed by an executive officer of Purchaser, confirming that, to the actual<br \/>\nknowledge of such executive officer, the conditions set forth in Sections 7.1 and 7.2 have been satisfied; and <\/p>\n<p><\/font><\/dd>\n<dt><font size=\"2\"><b>(ii)<\/b><\/font><\/dt>\n<dd><font size=\"2\">such good standing certificates and other similar documents as Seller may reasonably request to<br \/>\nensure that the actions required to be taken by Purchaser at the Closing have been properly authorized. <\/font><\/dd>\n<\/dl>\n<\/ul>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.6<\/b><\/font><font size=\"2\"><b>  No Restraints.<\/b><\/font><font size=\"2\">  No injunction or other order<br \/>\npreventing the consummation of the transactions contemplated by this Agreement shall have been issued since the date of this Agreement by any United States federal or state court of competent<br \/>\njurisdiction and shall remain in effect; and no United States federal or state Legal Requirement that makes consummation of the transactions contemplated by this Agreement illegal shall have been<br \/>\nenacted or adopted since the date of this Agreement and shall remain in effect. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.7<\/b><\/font><font size=\"2\"><b>  Nasdaq Listing.<\/b><\/font><font size=\"2\">  The Initial Shares shall have been<br \/>\nlisted and approved for quotation on The Nasdaq National Market. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>7.8<\/b><\/font><font size=\"2\"><b>  Consents.<\/b><\/font><font size=\"2\">  The Consents identified on<br \/>\nSchedule 7 shall have been obtained. <\/font><\/p>\n<p><font size=\"2\"><b>8.  TERMINATION.<\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>8.1<\/b><\/font><font size=\"2\"><b>  Right to Terminate Agreement.<\/b><\/font><font size=\"2\">  This Agreement may be<br \/>\nterminated prior to the Closing: <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> by the mutual written consent of the Parties; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> by either Party (by delivery of a written termination notification in accordance with Section 8.2) at any<br \/>\ntime after February 15, 2002 if the Closing has not taken place on or before February 15, 2002, unless the failure of the Closing to take place on or before such date is attributable to<br \/>\na breach by such Party of any of its obligations set forth in this Agreement or in any of the Ancillary Agreements; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> by Seller (by delivery of a written termination notification in accordance with Section 8.2) if<br \/>\n(i) there shall have been a breach on the part of Purchaser of any of its representations, warranties or covenants such that the condition set forth in Section 7.1 or Section 7.2,<br \/>\nas the case may be, would not be satisfied as of the time of such breach, (ii) Seller shall have given written notice of such breach to Purchaser, (iii) at least twenty days shall have<br \/>\nelapsed since the delivery of such written notice to Purchaser, (iv) such breach shall not have been cured and (v) Purchaser shall not be using its commercially reasonable efforts to<br \/>\nattempt to cure such breach; or <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> by Purchaser (by delivery of a written termination notification in accordance with Section 8.2) if<br \/>\n(i) there shall have been a breach on the part of Seller of any of its representations, warranties or covenants such that the condition set forth in Section 6.1 or Section 6.2, as<br \/>\nthe case may be, would not be satisfied as of the time of such breach, (ii) Purchaser shall have given <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">14<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_15\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\nwritten notice of such breach to Seller, (iii) at least twenty days shall have elapsed since the delivery of such written notice to Seller, (iv) such breach shall not have been cured and<br \/>\n(v) Seller shall not be using its commercially reasonable efforts to attempt to cure such breach. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>8.2<\/b><\/font><font size=\"2\"><b>  Termination Procedures.<\/b><\/font><font size=\"2\">  If either Party wishes to<br \/>\nterminate this Agreement pursuant to Section 8.1, such Party will deliver to the other Party a written termination notification stating that such Party is terminating this Agreement and setting<br \/>\nforth a brief statement of the basis on which such Party is terminating this Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>8.3<\/b><\/font><font size=\"2\"><b>  Effect of Termination.<\/b><\/font><font size=\"2\">  Upon the termination of this<br \/>\nAgreement pursuant to Section 8.1, neither Party will have any obligation or other liability to the other Party, except that (i) the Parties will remain bound by the provisions of<br \/>\nSection 10 and by the provisions of the Confidentiality Agreements, and (ii) neither Party will be relieved of any liability for any breach of its obligation to consummate the<br \/>\ntransactions contemplated by this Agreement or its obligation to take any other action required to be taken by such Party at or before the Closing. <\/font><\/p>\n<p><font size=\"2\"><b>9.  INDEMNIFICATION.  <\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>9.1  Survival of Representations; Indemnification by Seller.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> All of the representations and warranties of Seller set forth in this Agreement and in any certificate delivered<br \/>\npursuant to this Agreement, and all covenants of Seller set forth in Section 4, will terminate and expire, and will cease to be of any force or effect, on the Closing Date, and all liability of<br \/>\nSeller with respect to such representations, warranties and covenants (and any liability with respect to the certificate delivered to Purchaser pursuant to Section 6.4(a)) will thereupon be<br \/>\nextinguished. Notwithstanding the prior sentence: <\/font><\/p>\n<ul>\n<p><font size=\"2\">     <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\"> the representations and warranties of Seller set forth in Sections 2.1, 2.3(a), 2.5 and 2.7 (and the certificate<br \/>\ndelivered to Purchaser pursuant to Section 6.4(a), to the extent it relates to such representations and warranties) will survive the Closing but will terminate and expire, and will cease to be<br \/>\nof any force or effect, at 10:00 a.m. (California time) on the first anniversary of the Closing Date and all liability of Seller with respect to such representations and warranties (and any<br \/>\nliability with respect to the certificate delivered pursuant to Section 6.4(a), to the extent it relates to such representations and warranties) will thereupon be extinguished; <\/font> <font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">,<br \/>\nthat if, prior to such first anniversary, Purchaser shall have duly delivered to Seller, in conformity with all of the applicable<br \/>\nprocedures set forth in Section 9.1(f), a Claim Notice setting forth a claim for indemnification based upon Seller&#8217;s breach of any of such representations or warranties, then the specific claim<br \/>\nset forth in such Claim Notice will survive (and will not be extinguished upon) such first anniversary; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(ii)<\/b><\/font><font size=\"2\"> the representations and warranties of Seller set forth in Section 2.2 (and the certificate delivered to<br \/>\nPurchaser pursuant to Section 6.4(a), to the extent it relates to such representations and warranties) will survive the Closing but will terminate and expire, and will cease to be of any force<br \/>\nor effect, at 10:00 a.m. (California time) on the date eighteen months after the Closing Date, and all liability of Seller with respect to such representations and warranties (and any liability<br \/>\nwith respect to the certificate delivered pursuant to Section 6.4(a), to the extent it relates to such representations and warranties) will thereupon be extinguished; <\/font> <font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that if,<br \/>\nprior to such date, Purchaser shall have duly delivered to Seller, in conformity with all of the applicable procedures set<br \/>\nforth in Section 9.1(f), a Claim Notice setting forth a claim for indemnification based upon Seller&#8217;s breach of any of such representations or warranties, then the specific claim set forth in<br \/>\nsuch Claim Notice will survive (and will not be extinguished upon) such date; and <\/font><\/p>\n<p><font size=\"2\">   <\/font><font size=\"2\"><b>(iii)<\/b><\/font><font size=\"2\"> the representations and warranties of Seller set forth in Sections 2.4(b), 2.4(c), 2.4(d), 2.4(e), 2.4(f) and<br \/>\n2.4(g) (and the certificate delivered to Purchaser pursuant to Section 6.4(a), <\/font><\/p>\n<\/ul>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">15<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_16\"> <\/a><\/p>\n<ul>\n<ul>\n<p><font size=\"2\"><br \/>\nto the extent it relates to such representations and warranties) will survive the Closing but will terminate and expire, and will cease to be of any force or effect, at 10:00 a.m. (California<br \/>\ntime) on the third anniversary of the Closing Date, and all liability of Seller with respect to such representations and warranties (and any liability with respect to the certificate delivered<br \/>\npursuant to Section 6.4(a), to the extent it relates to such representations and warranties) will thereupon be extinguished; <\/font><font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">,<br \/>\nthat if, prior to such third anniversary, Purchaser shall have duly delivered to Seller, in conformity with all of the applicable procedures set forth in Section 9.1(f), a Claim Notice setting<br \/>\nforth a claim for indemnification based upon Seller&#8217;s breach of any of such representations or warranties,<br \/>\nthen the specific claim set forth in such Claim Notice will survive (and will not be extinguished upon) such third anniversary. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Subject to the limitations set forth in this Section 9.1 and elsewhere in this Agreement, from and after the<br \/>\nClosing Date, Seller will indemnify Purchaser against any Damages that Purchaser incurs as a result of any breach by Seller of any of the Specified Representations. Seller&#8217;s obligation to indemnify<br \/>\nPurchaser pursuant to this Section 9.1(b) will not relieve Seller of, or alter in any way, Seller&#8217;s obligation to fully satisfy all of Seller&#8217;s liabilities other than the Assumed Liabilities. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> Seller will not be required to indemnify Purchaser with respect to any breach by Seller of any of the Specified<br \/>\nRepresentations, except to the extent that the cumulative amount of the Damages actually incurred by Purchaser as a result of all such breaches of the Specified Representations exceeds $3,000,000; and<br \/>\nSeller will only be required to pay, and will only be liable for, the amount by which the cumulative amount of the Damages actually incurred by Purchaser as a result of all such breaches of the<br \/>\nSpecified Representations exceeds $3,000,000. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> The total amount of the payments that Seller can be required to make under or in connection with this Agreement<br \/>\n(including all indemnification payments required to be made to Purchaser with respect to breaches of the Specified Representations and all amounts payable to any counsel retained in accordance with<br \/>\nSection 9.1(g)) will be limited in the aggregate to a maximum of $42,500,000, and Seller&#8217;s cumulative liability will in no event exceed such amount. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> Any indemnification payment required to be made by Seller under this Agreement may be made (at Seller&#8217;s election) in<br \/>\ncash or by delivery of shares of Purchaser Common Stock (or by delivery of a combination of cash and shares of Purchaser Common Stock). For purposes of this Section 9.1(e), each share of<br \/>\nPurchaser Common Stock delivered to Purchaser will represent an indemnification payment in an amount equal to the Closing Five-Day Average Stock Price (subject to appropriate adjustment to<br \/>\nreflect any stock split, stock dividend, recapitalization or other similar transaction affecting the Purchaser Common Stock that is effected or has a record date on or prior to the date of delivery of<br \/>\nsuch Purchaser Common Stock to Purchaser). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(f)<\/b><\/font><font size=\"2\">  If Purchaser wishes to assert an indemnification claim against Seller, Purchaser will deliver to Seller, as soon as<br \/>\nreasonably practicable, a written notice (a &#8220;Claim Notice&#8221;) setting forth: <\/font><\/p>\n<ul>\n<p><font size=\"2\">     <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\"> the specific representation and warranty alleged to have been breached by Seller; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(ii)<\/b><\/font><font size=\"2\"> a reasonably detailed description of the facts and circumstances giving rise to the alleged breach of such<br \/>\nrepresentation and warranty; and <\/font><\/p>\n<p><font size=\"2\">   <\/font><font size=\"2\"><b>(iii)<\/b><\/font><font size=\"2\"> a reasonably detailed description of, and a good faith estimate of the total amount of, the Damages actually<br \/>\nincurred or expected to be incurred by Purchaser as a result of such alleged breach. <\/font><\/p>\n<\/ul>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">16<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_17\"> <\/a><\/p>\n<ul>\n<ul>\n<\/ul>\n<p><font size=\"2\">Notwithstanding<br \/>\nanything to the contrary contained in this Agreement, Purchaser will not be permitted to deliver any Claim Notice to Seller (and will not be entitled to assert any claim set forth in<br \/>\nany Claim Notice) unless Purchaser has reasonably determined that the breach alleged in such Claim Notice has actually occurred. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(g)<\/b><\/font><font size=\"2\"> If Purchaser receives notice or otherwise obtains knowledge of any Matter or any threatened Matter that may<br \/>\nreasonably be expected to give rise to an indemnification claim against Seller, then Purchaser will deliver to Seller a written notice describing such Matter in reasonable detail as soon as reasonably<br \/>\npracticable; <\/font><font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that for the sole purpose of determining whether a Matter or threatened Matter may give rise to an indemnification claim<br \/>\nagainst Seller within the meaning of this sentence, the limitation set forth in Section 9.1(c) will not be taken into account. Seller will have the right, at its election and at its sole<br \/>\nexpense, to assume the defense of any such Matter with its own counsel. If Seller elects to assume the defense of any such Matter, then: <\/font><\/p>\n<ul>\n<p><font size=\"2\">     <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\"> notwithstanding anything to the contrary contained in this Agreement, Seller will not be required to pay or<br \/>\notherwise indemnify Purchaser against any attorneys&#8217; fees or other expenses incurred on behalf of Purchaser in connection with such Matter following Seller&#8217;s election to assume the defense of such<br \/>\nMatter; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(ii)<\/b><\/font><font size=\"2\"> Purchaser will make available to Seller all books, records and other documents and materials that are under the<br \/>\ncontrol of Purchaser or any of Purchaser&#8217;s affiliates, advisors or representatives and that Seller reasonably considers necessary or desirable for the defense of such Matter; <\/font><\/p>\n<p><font size=\"2\">   <\/font><font size=\"2\"><b>(iii)<\/b><\/font><font size=\"2\"> Purchaser will execute such documents and take such other actions as Seller may reasonably request for the purpose<br \/>\nof facilitating the defense of, or any settlement, compromise or adjustment relating to, such Matter; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(iv)<\/b><\/font><font size=\"2\"> Purchaser will otherwise fully cooperate as reasonably requested by Seller in the defense of such Matter; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(v)<\/b><\/font><font size=\"2\"> Purchaser will not admit any liability with respect to such Matter; and <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(vi)<\/b><\/font><font size=\"2\"> Seller will have the exclusive right to settle, adjust or compromise such Matter, on such terms as Seller may<br \/>\nconsider appropriate, with the consent of Purchaser (which will not be unreasonably withheld). <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">If<br \/>\nSeller elects not to assume the defense of such Matter, then Purchaser will proceed diligently to defend such Matter with the assistance of counsel reasonably satisfactory to Seller; <\/font> <font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">,<br \/>\nthat Purchaser will not settle, adjust or compromise such Matter, or admit any liability with respect to such Matter, without the<br \/>\nprior written consent of Seller (which will not be unreasonably withheld). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(h)<\/b><\/font><font size=\"2\"> To the extent Seller makes or is required to make any indemnification payment to Purchaser, Seller will be entitled<br \/>\nto exercise, and will be subrogated to, any rights and remedies (including rights of indemnity, rights of contribution and other rights of recovery) that Purchaser or any of Purchaser&#8217;s affiliates may<br \/>\nhave against any other Person with respect to any Damages, circumstances or Matter to which such indemnification payment is directly or indirectly related. Purchaser will take such actions as Seller<br \/>\nmay reasonably request for the purpose of enabling Seller to perfect or exercise Seller&#8217;s right of subrogation hereunder. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(i)<\/b><\/font><font size=\"2\">  The right of Purchaser to assert indemnification claims and receive indemnification payments pursuant to this<br \/>\nSection 9.1 will be the sole and exclusive right and remedy exercisable by Purchaser with respect to any breach by Seller of any representation or warranty set forth in this Agreement or in any<br \/>\nof the Ancillary Agreements; <\/font><font size=\"2\"><i>provided, however,<\/i><\/font><font size=\"2\"> that this <\/font><\/p>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">17<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_18\"> <\/a><\/p>\n<ul>\n<p><font size=\"2\"><br \/>\nSection 9.1(i) shall not prevent Purchaser from asserting a tort claim for fraud against Seller in appropriate circumstances. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>9.2  Indemnification by Purchaser.<\/b><\/font><font size=\"2\">  The Parties acknowledge that Purchaser&#8217;s indemnification obligations<br \/>\nwith respect to breaches of the representations and warranties set forth in Section 3 are set forth in the Investor Rights Agreement, and that Purchaser&#8217;s indemnification obligations with<br \/>\nrespect to the Assumed Liabilities are set forth in the Assumption Agreement. <\/font><\/p>\n<p><font size=\"2\"><b>10.  MISCELLANEOUS.  <\/b><\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.1  Time of Essence.<\/b><\/font><font size=\"2\">  Time is of the essence of this Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.2  No Other Representations.<\/b><\/font><font size=\"2\">  The Parties acknowledge that, except as expressly set forth in Sections<br \/>\n2 and 3 and in the Ancillary Agreements, neither Party has made or is making any representations or warranties whatsoever to the other, implied or otherwise. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.3  Knowledge.<\/b><\/font><font size=\"2\">  Neither Party will be deemed to have breached any representation or warranty that is<br \/>\nmade to such Party&#8217;s &#8220;knowledge&#8221; unless an officer of such Party with the rank of Vice President or above has actual knowledge, as of the date of this Agreement, that such representation or warranty<br \/>\nis materially inaccurate. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.4  Access of Seller to Books and Records.<\/b><\/font><font size=\"2\">  At all times after the Closing Date, Purchaser will give<br \/>\nSeller and Seller&#8217;s advisors and representatives reasonable access to all books and records of Seller that are included in the Specified Assets (to the extent such books and records relate to any<br \/>\nperiod prior to the Closing Date). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.5  Governing Law.<\/b><\/font><font size=\"2\">  This Agreement will be construed in accordance with, and governed in all respects<br \/>\nby, the laws of the State of Colorado (without giving effect to principles of conflicts of law). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.6  Venue and Jurisdiction.<\/b><\/font><font size=\"2\">  If any legal proceeding or other legal action relating to this Agreement<br \/>\nis brought or otherwise initiated, the venue therefor will be in the State of Colorado, which will be deemed to be a convenient forum. Purchaser and Seller hereby expressly and irrevocably consent and<br \/>\nsubmit to the jurisdiction of the state and federal courts in the State of Colorado. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.7  Notices.<\/b><\/font><font size=\"2\">  Any notice or other communication required or permitted to be delivered to either Party<br \/>\nunder this Agreement must be in writing and will be deemed properly delivered, given and received when delivered (by hand, by registered mail, by courier or express delivery service or by facsimile)<br \/>\nto the address or facsimile telephone number set forth beneath the name of such Party below (or to such other address or facsimile telephone number as such Party shall have specified in a written<br \/>\nnotice given to the other Party): <\/font><\/p>\n<ul>\n<ul>\n<ul>\n<p><font size=\"2\">if<br \/>\nto Purchaser: <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">OSI<br \/>\nPharmaceuticals, Inc.<br \/> <br \/>\n58 South Service Road<br \/> <br \/>\nMelville, New York 11747<br \/> <br \/>\nAttention: Barbara Wood, General Counsel<br \/> <br \/>\nFacsimile: (631) 962-2021 <\/font><\/p>\n<ul>\n<p><font size=\"2\">with<br \/>\na copy to: <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">Mintz<br \/>\nLevin Cohn Ferris Glovsky &amp; Popeo, PC<br \/> <br \/>\n666 Third Avenue<br \/> <br \/>\nNew York, New York 10017<br \/> <br \/>\nAttention: Joel Papernik<br \/> <br \/>\nFacsimile: (212) 983-3115 <\/font><\/p>\n<\/ul>\n<\/ul>\n<p align=\"CENTER\"><font size=\"2\">18<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_19\"> <\/a><\/p>\n<ul>\n<ul>\n<ul>\n<p><font size=\"2\">if<br \/>\nto Seller: <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">Gilead<br \/>\nSciences, Inc.<br \/> <br \/>\n333 Lakeside Drive<br \/> <br \/>\nFoster City, CA 94404<br \/> <br \/>\nAttention: Gregg Alton, General Counsel<br \/> <br \/>\nFacsimile: (650) 522-5537<br \/><\/font><\/p>\n<ul>\n<p><font size=\"2\">with<br \/>\na copy to: <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">Cooley<br \/>\nGodward LLP<br \/> <br \/>\nFive Palo Alto Square<br \/> <br \/>\n3000 El Camino Real<br \/> <br \/>\nPalo Alto, CA 94306<br \/> <br \/>\nAttention: Robert Jones<br \/> <br \/>\nFacsimile: (650) 849-7400 <\/font><\/p>\n<\/ul>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.8  Public Announcements.<\/b><\/font><font size=\"2\">  Except as may be required by any Legal Requirement, neither Party will (and<br \/>\nneither Party will permit any of its advisors or representatives to) issue any press release or make any public statement regarding this Agreement or any of the transactions contemplated by this<br \/>\nAgreement, without the other Party&#8217;s prior written consent (which will not be unreasonably withheld). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.9  Assignment.<\/b><\/font><font size=\"2\">  Neither Party may assign any of its rights or delegate any of its obligations under<br \/>\nthis Agreement (whether voluntarily, involuntarily, by way of merger or otherwise) to any other Person without the prior written consent of the other Party; <\/font><font size=\"2\"><i>provided,<br \/>\nhowever<\/i><\/font><font size=\"2\">, that Seller may, before or after the Closing, (i) assign to any Person its right to receive all or any portion of any of the cash payments to be made by<br \/>\nPurchaser pursuant to Section 1.3 and (ii) assign, to any Person that assumes the applicable obligations of Seller under the Investor Rights Agreement, any or all of Seller&#8217;s rights to<br \/>\nreceive the Initial Shares or any Subsequent Shares; and <\/font><font size=\"2\"><i>provided further<\/i><\/font><font size=\"2\">, that (without limiting Purchaser&#8217;s obligations under or relating to this<br \/>\nAgreement) Purchaser may, before the Closing, assign its right to receive all or any of the Specified Assets to an affiliate of Purchaser. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.10  Parties in Interest.<\/b><\/font><font size=\"2\">  Nothing in this Agreement is intended to provide any rights or remedies to<br \/>\nany employee of Seller or to any other Person other than the Parties. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.11  Severability.<\/b><\/font><font size=\"2\">  In the event that any provision of this Agreement, or the application of such<br \/>\nprovision to any Person or set of circumstances, shall be determined to be invalid, unlawful, void or unenforceable to any extent, the remainder of this Agreement, and the application of such<br \/>\nprovision to Persons or circumstances other than those as to which it is determined to be invalid, unlawful, void or unenforceable, will not be affected and will continue to be valid and enforceable<br \/>\nto the fullest extent permitted by law. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.12  Entire Agreement.<\/b><\/font><font size=\"2\">  This Agreement, the Confidentiality Agreements (which remain in full force and<br \/>\neffect), the Assumption Agreement and the Ancillary Agreements set forth the entire understanding of the Parties and supersede all other agreements and understandings between the Parties relating to<br \/>\nthe subject matter hereof and thereof. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.13  Waiver.<\/b><\/font><font size=\"2\">  No failure on the part of either Party to exercise any power, right, privilege or remedy<br \/>\nunder this Agreement, and no delay on the part of either Party in exercising any power, right, privilege or remedy under this Agreement, will operate as a waiver thereof; and no single or partial<br \/>\nexercise of any such power, right, privilege or remedy will preclude any other or further exercise thereof or of any other power, right, privilege or remedy. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.14  Amendments.<\/b><\/font><font size=\"2\">  This Agreement may not be amended, modified, altered or supplemented except by means<br \/>\nof a written instrument executed on behalf of both Parties. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">19<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_ki1006_1_20\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>10.15  Counterparts.<\/b><\/font><font size=\"2\">  This Agreement may be executed in several counterparts, each of which will<br \/>\nconstitute an original and all of which, when taken together, will constitute one agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.16  Interpretation of Agreement.<\/b><\/font><font size=\"2\">  <\/font><\/p>\n<ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(a)<\/b><\/font><font size=\"2\"> Each Party acknowledges that it has participated in the drafting of this Agreement, and any applicable rule of<br \/>\nconstruction to the effect that ambiguities are to be resolved against the drafting party will not be applied in connection with the construction or interpretation of this Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(b)<\/b><\/font><font size=\"2\"> Whenever required by the context hereof, the singular number will include the plural, and vice versa; the masculine<br \/>\ngender will include the feminine and neuter genders; and the neuter gender will include the masculine and feminine genders. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(c)<\/b><\/font><font size=\"2\"> As used in this Agreement, the words &#8220;include&#8221; and &#8220;including,&#8221; and variations thereof, will not be deemed to be<br \/>\nterms of limitation, and will be deemed to be followed by the words &#8220;without limitation.&#8221; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(d)<\/b><\/font><font size=\"2\"> Unless the context otherwise requires, references in this Agreement to &#8220;Sections,&#8221; &#8220;Schedules&#8221; and &#8220;Exhibits&#8221; are<br \/>\nintended to refer to Sections of and Schedules and Exhibits to this Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>(e)<\/b><\/font><font size=\"2\"> The table of contents of this Agreement and the bold-faced headings contained in this Agreement are for<br \/>\nconvenience of reference only, will not be deemed to be a part of this Agreement and will not be referred to in connection with the construction or interpretation of this Agreement. <\/font><\/p>\n<\/ul>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>10.17  Further Assurances.<\/b><\/font><font size=\"2\">  For a period of one year following the Closing, (i) Seller will use<br \/>\ncommercially reasonable efforts to make available to Purchaser the material benefits of any Specified Contract that (a) was not assigned to Purchaser as a result of the failure to obtain any<br \/>\nConsent identified in Part 2.10 of the Seller Disclosure Schedule or (b) is not assignable and for which a waiver has not been received or obtained and (ii) each Party will, to<br \/>\nthe extent reasonably requested by the other Party and at such other Party&#8217;s sole expense, execute and deliver such documents and instruments and take such other actions as such other Party may<br \/>\nreasonably request in order to consummate and make effective the transactions contemplated by this Agreement. <\/font><\/p>\n<p><font size=\"2\">    The<br \/>\nParties have caused this Agreement to be executed as of November 26, 2001. <\/font><\/p>\n<table width=\"78%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tr valign=\"TOP\">\n<td width=\"47%\"><font size=\"2\"> <\/font><\/td>\n<td width=\"3%\"><font size=\"2\"> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><b>GILEAD SCIENCES, INC.<\/b><\/font><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"47%\"><font size=\"2\"><br \/>\n <\/font><\/td>\n<td width=\"3%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"5%\"><font size=\"2\"><br \/>\nBy:<\/font><\/td>\n<td width=\"1%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"45%\" align=\"CENTER\"><font size=\"2\"><br \/>\n\/s\/ <\/font><font size=\"2\">MARK PERRY<\/font><font size=\"2\">   <\/font><\/p>\n<hr noshade><font size=\"2\"> Mark Perry, <\/font><font size=\"2\"><i>Executive Vice President, Operations<\/i><\/font><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"47%\"><font size=\"2\"><br \/>\n <\/font><\/td>\n<td width=\"3%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td colspan=\"3\"><font size=\"2\"><b>OSI PHARMACEUTICALS, INC.<\/b><\/font><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"47%\"><font size=\"2\"><br \/>\n <\/font><\/td>\n<td width=\"3%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"5%\"><font size=\"2\"><br \/>\nBy:<\/font><\/td>\n<td width=\"1%\"><font size=\"2\"><br \/> <\/font><\/td>\n<td width=\"45%\" align=\"CENTER\"><font size=\"2\"><br \/>\n\/s\/ <\/font><font size=\"2\">COLIN GODDARD<\/font><font size=\"2\">   <\/font><\/p>\n<hr noshade><font size=\"2\"> Colin Goddard, <\/font><font size=\"2\"><i>Chairman and CEO<\/i><\/font><\/td>\n<\/tr>\n<\/table>\n<p align=\"CENTER\"><font size=\"2\">20<\/font><\/p>\n<hr noshade>\n<p align=\"CENTER\"><font size=\"2\"><a name=\"page_kk1006_1_1\"> <\/a> <\/font> <font size=\"2\"><b>EXHIBIT A  <\/b><\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\"><b> CERTAIN DEFINITIONS  <\/b><\/font><\/p>\n<p><font size=\"2\">    For purposes of the Agreement: <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Agreement&#8221;<\/b><\/font><font size=\"2\"> means the Asset Purchase Agreement to which this Exhibit A is attached, including the Seller Disclosure Schedule and<br \/>\nthe Purchaser Disclosure Schedule. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Allocation&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.5. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Ancillary Agreements&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.6. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;API&#8221;<\/b><\/font><font size=\"2\"> means (i) with respect to GS7904L, the thymidylate synthase inhibitor GW1843; (ii) with respect to GS7836, the<br \/>\ncompound referred to by Seller as 4&#8242;-thio-ara-C; and (iii) with respect to NX211, lurtotecan. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Assumed Liabilities&#8221;<\/b><\/font><font size=\"2\"> means the following obligations and other liabilities (whether known, unknown, accrued, absolute, matured,<br \/>\nunmatured, contingent or otherwise, and whether arising before or after the Closing) as they may exist at and\/or after the Closing: (i) all obligations and other liabilities of Seller under or<br \/>\nrelating to the Specified Contracts; (ii) all obligations and other liabilities of Seller to Glaxo Wellcome Inc. and Glaxo Group Limited (or their successor(s) in interest, if any),<br \/>\nNorth Carolina State University and Southern Research Institute under or relating to any license agreement or other agreement relating to any of the Specified Products; (iii) all obligations<br \/>\nand other liabilities of Seller relating to any of the taxes, charges, fees and expenses that Purchaser is required to bear and pay pursuant to Section 1.4; and (iv) each other<br \/>\nobligation or other liability of Seller relating to any of the Specified Assets, any of the Specified Products, any of the Transferred Employees (as defined in the Employee Matters Agreement) or the<br \/>\noperations conducted at the Boulder Facility; <\/font><font size=\"2\"><i>provided, however,<\/i><\/font><font size=\"2\"> that (A) if the NCS\/NX211 Consent is not obtained, then &#8220;Assumed Liabilities&#8221;<br \/>\nwill not include the obligations set forth in Section 4.07 of the License Agreement between North Carolina State University and Glaxo Wellcome Inc. dated May 26, 1998; and<br \/>\n(B) if the SRI\/GS7836 Consent is not obtained, then &#8220;Assumed Liabilities&#8221; will not include the obligations set forth in Section 4.4 of the License Agreement between Southern Research<br \/>\nInstitute and Seller dated December 15, 2002. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Assumption Agreement&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.3(c). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Available Employees&#8221;<\/b><\/font><font size=\"2\"> means the employees of Seller who are based at the Boulder Facility or are listed on Schedule 8; <\/font> <font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that none of the<br \/>\nemployees identified on Schedule 6 will be deemed to be &#8220;Available Employees.&#8221; <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Boulder Facility&#8221;<\/b><\/font><font size=\"2\"> means the premises located at 2860 Wilderness Place, 2900 Center Green Court, 2970 Wilderness Place and 5311 Western<br \/>\nAve, Suite K, in Boulder, Colorado, that are being leased to Seller. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Claim Notice&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 9.1(f). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Closing&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.7. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Closing Date&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.7. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Closing Five-Day Average Stock Price&#8221;<\/b><\/font><font size=\"2\"> means the average of the closing sale prices of a share of Purchaser Common Stock as<br \/>\nreported on The Nasdaq National Market for the period of five consecutive trading days ending on the trading day immediately preceding the Closing Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Confidentiality Agreements&#8221;<\/b><\/font><font size=\"2\"> means the Confidentiality Agreement between the Parties dated as of September 20, 2001, and the<br \/>\nConfidentiality Agreement between the Parties dated as of November 1, 2001. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Consent&#8221;<\/b><\/font><font size=\"2\"> means any consent, approval or waiver. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">A\u00961<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kk1006_1_2\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>&#8220;Damages&#8221;<\/b><\/font><font size=\"2\"> means out-of-pocket losses and damages, excluding indirect, consequential, incidental, special and<br \/>\npunitive damages; <\/font><font size=\"2\"><i>provided, however<\/i><\/font><font size=\"2\">, that for purposes of computing the amount of Damages incurred by any Person, there will be deducted an amount equal<br \/>\nto the amount of any insurance<br \/>\nproceeds, indemnification payments, contribution payments or reimbursements actually received by such Person or any of such Person&#8217;s affiliates in connection with such Damages or the circumstances<br \/>\ngiving rise thereto. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Employee Matters Agreement&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.6(b). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Environmental Laws&#8221;<\/b><\/font><font size=\"2\"> means all federal, state or local laws (including any statute, rule, regulation, ordinance, code or rule of common<br \/>\nlaw), and all judicial or administrative interpretations thereof, and all decrees, judgments, policies, written guidance or judicial or administrative orders relating to the environment, health,<br \/>\nsafety or Hazardous Substances, including the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. \u00a79901 et seq., the Resource Conservation and Recovery Act of<br \/>\n1976, 42 U.S.C. \u00a7 6901 et seq., the Emergency Planning and Community Right-to-Know Act, 42 U.S.C. \u00a7 11001 et seq., the Clean Air Act, 42 U.S.C.<br \/>\n\u00a7 7401 et seq., the Federal Water Pollution Control Act, 33 U.S.C. \u00a7 1251 et seq., the Toxic Substance Control Act, 15 U.S.C. \u00a7 2601 et seq., the Safe Drinking<br \/>\nWater Act, U.S.C. \u00a7 300f et seq., the Occupational Safety and Health Act, 42 U.S.C. \u00a7 1801 et seq., the Federal Insecticide, Fungicide and Rodenticide Act, 7 U.S.C.<br \/>\n\u00a7 136 et seq., the Hazardous Materials Transportation Act, 49 U.S.C. \u00a7 1801 et seq., and their state counterparts or equivalents, all as amended, and any regulations or rules<br \/>\nadopted or promulgated pursuant thereto. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Environmental Permits&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in 2.4(d). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Exchange Act&#8221;<\/b><\/font><font size=\"2\"> means the Securities Exchange Act of 1934, as amended. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;FDA&#8221;<\/b><\/font><font size=\"2\"> means the United States Food and Drug Administration. <\/font><\/p>\n<p><font size=\"2\">    &#8220;<\/font><font size=\"2\"><b>GS7836<\/b><\/font><font size=\"2\">&#8221; means any formulation of the compound known as 4-thio-AraC, and any analogs, homologs, congeners and<br \/>\nderivatives thereof that are claimed in United States Provisional Patent Application No. 60\/093,869 filed July 23, 1998, Patent Cooperation Treaty Patent Application No. PCT\/US99\/16630<br \/>\nfiled July 23, 1999 or United States Patent Application Serial No. 09\/493,247 filed January 28, 2000, in each case as originally filed, together with intermediates therefor that<br \/>\nare useful specifically for the manufacture of 4-thio-AraC. <\/font><\/p>\n<p><font size=\"2\">    &#8220;<\/font><font size=\"2\"><b>GS7904L<\/b><\/font><font size=\"2\">&#8221; means any formulation of the thymidylate synthase inhibitor known as 1843U89 or GW 1843, and the analogs, homologs, congeners<br \/>\nand derivatives thereof that are claimed in United States Patent No. 5,663,337, issued September 2, 1997, together with intermediates therefor that are useful specifically for the<br \/>\nmanufacture of such thymidylate synthase inhibitor. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;GSK\/GS7904L Consent&#8221;<\/b><\/font><font size=\"2\"> means the Consent identified as item 19 of Part 2.10 of the Seller Disclosure Schedule that is to be<br \/>\nrequested from Glaxo Wellcome Inc. and Glaxo Group Limited (or their successor(s) in interest, if any). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;GSK\/NX211 Consent&#8221;<\/b><\/font><font size=\"2\"> means the Consent identified as item 21 of Part 2.10 of the Seller Disclosure Schedule that is to be<br \/>\nrequested from Glaxo Wellcome Inc. and Glaxo Group Limited (or their successor(s) in interest, if any). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Hazardous Substance&#8221;<\/b><\/font><font size=\"2\"> means any: contaminant or pollutant; toxic, radioactive or hazardous waste, chemical, substance, material or<br \/>\nconstituent; asbestos; polychlorinated byphenyls (PCBs); paint containing lead or mercury; fixtures containing mercury or urea formaldehyde; natural or liquefied gas; flammable, explosive, corrosive,<br \/>\nradioactive, medical and infectious waste; and oil or other petroleum product, all as defined in Environmental Laws. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;HSR Act&#8221;<\/b><\/font><font size=\"2\"> means the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and the rules promulgated thereunder. <\/font><\/p>\n<p align=\"CENTER\"><font size=\"2\">A\u00962<\/font><\/p>\n<hr noshade>\n<p><a name=\"page_kk1006_1_3\"> <\/a><\/p>\n<p><font size=\"2\"><br \/>\n    <\/font><font size=\"2\"><b>&#8220;Initial Shares&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.3(b). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Investor Rights Agreement&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 1.6(a). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Legal Requirement&#8221;<\/b><\/font><font size=\"2\"> means any law, rule or regulation of any governmental body. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Matter&#8221;<\/b><\/font><font size=\"2\"> means any claim, demand, dispute, action, suit, proceeding, investigation or other similar matter. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;NCS\/NX211 Consent&#8221;<\/b><\/font><font size=\"2\"> means the Consent identified as item 20 of Part 2.10 of the Seller Disclosure Schedule that is to be<br \/>\nrequested from North Carolina State University. <\/font><\/p>\n<p><font size=\"2\">    &#8220;<\/font><font size=\"2\"><b>NX211<\/b><\/font><font size=\"2\">&#8221; means any formulation of the topoisomerase I inhibitor known as GI147211C, more commonly known as lurtotecan, together with<br \/>\nsalts thereof and intermediates therefor that are useful specifically for the manufacture of lurtotecan. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;NX211 NDA Filing Date&#8221;<\/b><\/font><font size=\"2\"> means the first date on which (i) a New Drug Application relating to NX211 is filed with the FDA or<br \/>\n(ii) a similar filing is made with any equivalent to the FDA in Europe (whether such filing is made using a central filing procedure or in an individual European country). <\/font><\/p>\n<p><font size=\"2\">    &#8220;<\/font><font size=\"2\"><b>NX211 Phase III Commencement Date<\/b><\/font><font size=\"2\">&#8221; means the earlier of: (i) the date upon which the first dosing of a patient with NX211<br \/>\noccurs pursuant to a protocol for a clinical trial that is designed to provide pivotal safety and efficacy data regarding NX211 for a New Drug Application for submission to the FDA or similar filing<br \/>\nwith any foreign equivalent thereof; or (ii) the date upon which a New Drug Application is filed with the FDA or a similar filing is made with any equivalent to the FDA in Europe (whether such<br \/>\nfiling is made using a central filing procedure or in an individual European country), if no trial fulfilling all criteria set forth in clause &#8220;(i)&#8221; of this sentence shall have been conducted prior to<br \/>\nthe filing of such application. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Parties&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in the introductory paragraph of the Agreement. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Person&#8221;<\/b><\/font><font size=\"2\"> means any individual, corporation, general partnership, limited partnership, limited liability company, trust, association,<br \/>\nfirm, organization, company, business, entity, union, society or governmental body. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Phase III Twenty-Day Average Stock Price&#8221;<\/b><\/font><font size=\"2\"> means the average of the closing sale prices of a share of Purchaser Common<br \/>\nStock as reported on The Nasdaq National Market for the period of twenty consecutive trading days ending on the trading day immediately preceding the NX211 Phase III Commencement Date. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Pre-Closing Period&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 4.1. <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Purchaser Common Stock&#8221;<\/b><\/font><font size=\"2\"> means the common stock, par value $.01 per share, of Purchaser (or such other securities into which the shares<br \/>\nof such common stock shall be converted, whether by virtue of any recapitalization of Purchaser, any merger of Purchaser into another entity or otherwise). <\/font><\/p>\n<p><font size=\"2\">    <\/font><font size=\"2\"><b>&#8220;Purchaser Corporations&#8221;<\/b><\/font><font size=\"2\"> has the meaning set forth in Section 3.1. 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