{"id":43937,"date":"2015-09-17T11:25:58","date_gmt":"2015-09-17T16:25:58","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-legal\/contracts\/uncategorized\/stockholder-agreement-bristol-myers-squibb-co-bristol-myers.html"},"modified":"2015-09-17T11:25:58","modified_gmt":"2015-09-17T16:25:58","slug":"stockholder-agreement-bristol-myers-squibb-co-bristol-myers","status":"publish","type":"corporate_contracts","link":"https:\/\/corporate.findlaw.com\/contracts\/securities\/stockholder-agreement-bristol-myers-squibb-co-bristol-myers.html","title":{"rendered":"Stockholder Agreement &#8211; Bristol-Myers Squibb Co., Bristol-Myers Squibb Biologics Co. and ImClone Systems Inc."},"content":{"rendered":"<pre>                              STOCKHOLDER AGREEMENT\n\n                                   dated as of\n\n                               September 19, 2001\n\n                                      among\n\n                          BRISTOL-MYERS SQUIBB COMPANY,\n\n                     BRISTOL-MYERS SQUIBB BIOLOGICS COMPANY\n\n                                       and\n\n                          IMCLONE SYSTEMS INCORPORATED\n\n\n\n\n\n\n\n                                TABLE OF CONTENTS\n\n                                  ------------\n\n<\/pre>\n<table>\n<caption>\n                                                                                             PAGE<\/p>\n<p>                                    ARTICLE 1<br \/>\n                                   DEFINITIONS<\/p>\n<p><s>            <c>                                                                            <c><br \/>\nSECTION 1.01.  DEFINITIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.1<\/p>\n<p>                                    ARTICLE 2<br \/>\n                              CORPORATE GOVERNANCE<\/p>\n<p>SECTION 2.01.  COMPOSITION OF THE BOARD OF DIRECTORS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.10<br \/>\nSECTION 2.02.  SOLICITATION AND VOTING OF SHARES&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..12<br \/>\nSECTION 2.03.  COMMITTEES OF THE BOARD OF DIRECTORS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..12<br \/>\nSECTION 2.04.  BMS APPROVAL REQUIRED FOR CERTAIN ACTIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;13<\/p>\n<p>                                    ARTICLE 3<br \/>\n          LIMITATIONS ON ADDITIONAL PURCHASES OF COMMON STOCK AND OTHER<br \/>\n                                     ACTIONS<\/p>\n<p>SECTION 3.01.  PURCHASES OF COMMON STOCK&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.15<br \/>\nSECTION 3.02.  ADDITIONAL LIMITATIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.15<br \/>\nSECTION 3.03.  STANDSTILL EXCEPTIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..16<br \/>\nSECTION 3.04.  BMS DILUTION OPTION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.18<\/p>\n<p>                                    ARTICLE 4<br \/>\n                              TRANSFER RESTRICTIONS<\/p>\n<p>SECTION 4.01.  TRANSFER OF COMMON STOCK&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..21<br \/>\nSECTION 4.02.  TRANSFER OF SHARES OF THE EQUITY HOLDING ENTITY&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;22<\/p>\n<p>                                    ARTICLE 5<br \/>\n                               REGISTRATION RIGHTS<\/p>\n<p>SECTION 5.01.  REGISTRATION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..23<br \/>\nSECTION 5.02.  PIGGYBACK REGISTRATION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.23<br \/>\nSECTION 5.03.  REDUCTION OF OFFERING&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..24<br \/>\nSECTION 5.04.  REGISTRATION PROCEDURES&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;24<br \/>\nSECTION 5.05.  CONDITIONS TO OFFERINGS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;26<br \/>\nSECTION 5.06.  ADDITIONAL CONDITIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..27<br \/>\nSECTION 5.07.  REGISTRATION EXPENSES&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..28<br \/>\nSECTION 5.08.  INDEMNIFICATION; CONTRIBUTION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;28<\/p>\n<p><s>            <c>                                                                            <c><br \/>\nSECTION 5.09.  RULE 144&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;31<br \/>\nSECTION 5.10.  LOCKUP&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..31<\/p>\n<p>                                    ARTICLE 6<br \/>\n                                  MISCELLANEOUS<\/p>\n<p>SECTION 6.01.  NOTICES&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.32<br \/>\nSECTION 6.02.  AMENDMENTS; WAIVERS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\nSECTION 6.03.  SUCCESSORS AND ASSIGNS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.33<br \/>\nSECTION 6.04.  CAPTIONS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;33<br \/>\nSECTION 6.05.  SEVERABILITY&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..33<br \/>\nSECTION 6.06.  SPECIFIC PERFORMANCE&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;33<br \/>\nSECTION 6.07.  GOVERNING LAW&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.34<br \/>\nSECTION 6.08.  JURISDICTION&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\nSECTION 6.09.  WAIVER OF JURY TRIAL&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;34<br \/>\nSECTION 6.10.  COUNTERPARTS; EFFECTIVENESS; BENEFIT&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..34<br \/>\nSECTION 6.11.  ENTIRE AGREEMENT&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.34<br \/>\nSECTION 6.12.  EXPENSES&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;35<br \/>\nSECTION 6.13.  ADDITIONAL COVENANT OF BMS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;35<br \/>\n<\/c><\/c><\/s><\/c><\/c><\/s><\/caption>\n<\/table>\n<p>                                       ii<\/p>\n<p>                              STOCKHOLDER AGREEMENT<\/p>\n<p>         STOCKHOLDER AGREEMENT dated as of September 19, 2001 (this &#8220;AGREEMENT&#8221;)<br \/>\namong BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (&#8220;BMS&#8221;),<br \/>\nBRISTOL-MYERS SQUIBB BIOLOGICS COMPANY, a Delaware corporation and a wholly<br \/>\nowned subsidiary of BMS (&#8220;ACQUISITION SUB&#8221;), and IMCLONE SYSTEMS INCORPORATED, a<br \/>\nDelaware corporation (the &#8220;COMPANY&#8221;).<\/p>\n<p>         WHEREAS, each of the Boards of Directors of BMS, Acquisition Sub and<br \/>\nthe Company has approved this Agreement and the transactions contemplated<br \/>\nhereby;<\/p>\n<p>         WHEREAS, simultaneously with the execution of this Agreement, the<br \/>\nCompany, BMS and Acquisition Sub are entering into an Acquisition Agreement (the<br \/>\n&#8220;ACQUISITION AGREEMENT&#8221;), pursuant to which, among other things, BMS and<br \/>\nAcquisition Sub shall commence a tender offer to acquire shares of the Company&#8217;s<br \/>\ncommon stock; and<\/p>\n<p>         WHEREAS, simultaneously with the execution of this Agreement, the<br \/>\nCompany, BMS and E.R. Squibb &amp; Sons, L.L.C., a limited liability company formed<br \/>\nunder the laws of Delaware and a wholly owned subsidiary of BMS (&#8220;ERS&#8221;) are<br \/>\nentering into a Development, Promotion, Distribution and Supply Agreement (the<br \/>\n&#8220;COMMERCIAL ARRANGEMENTS&#8221;), pursuant to which, among other things, the Company,<br \/>\nBMS and ERS will co-develop and co-promote the biologic pharmaceutical product<br \/>\nIMC-C225 in the United States, Canada and Japan.<\/p>\n<p>         NOW, THEREFORE, in consideration of the respective representations,<br \/>\nwarranties, covenants, agreements and conditions herein, the parties hereto<br \/>\nhereby agree as follows:<\/p>\n<p>                                    ARTICLE 1<br \/>\n                                   DEFINITIONS<\/p>\n<p>         SECTION 1.01. DEFINITIONS. (a) The following terms, as used herein,<br \/>\nhave the following meanings:<\/p>\n<p>         &#8220;AFFILIATE&#8221; of any Person means any other Person directly or indirectly<br \/>\ncontrolling, controlled by or under common control with such Person; PROVIDED<br \/>\nthat for purposes of this Agreement, neither the Company nor any of its<\/p>\n<p>Subsidiaries shall be deemed an Affiliate of BMS or the Equity Holding Entity.<br \/>\nFor the purposes of this definition, &#8220;CONTROL&#8221; when used with respect to any<br \/>\nPerson, means the possession, directly or indirectly, of the power to direct or<br \/>\ncause the direction of the management and policies of such Person, whether<br \/>\nthrough the ownership of voting securities, by contract or otherwise; and the<br \/>\nterms &#8220;CONTROLLING&#8221; and &#8220;CONTROLLED&#8221; have meanings correlative to the foregoing.<\/p>\n<p>         &#8220;BMS DILUTION EVENT&#8221; means (a) the date which is forty-five calendar<br \/>\ndays after any date after the Effective Time on which BMS&#8217; Common Stock Interest<br \/>\nis less than 5%; PROVIDED that if the Equity Holding Entity acquires shares of<br \/>\nCommon Stock within such forty-five calendar day period so that, at any time<br \/>\nprior to the end of such forty-five calendar day period, BMS&#8217; Common Stock<br \/>\nInterest is equal to or greater than 5%, then a BMS Dilution Event shall not be<br \/>\ndeemed to have occurred on such date, or (b) Acquisition Sub not acquiring 5% or<br \/>\nmore of the outstanding Common Stock in the Initial Acquisition; PROVIDED that,<br \/>\nfor purposes of Section 3.03(b)(i) of this Agreement, the term &#8220;BMS&#8217; Beneficial<br \/>\nInterest&#8221; shall be substituted for the term &#8220;BMS&#8217; Common Stock Interest&#8221; in this<br \/>\ndefinition of BMS Dilution Event.<\/p>\n<p>         &#8220;BMS DIRECTOR&#8221; means a Director who is designated for such position by<br \/>\nBMS in accordance with Section 2.01.<\/p>\n<p>         &#8220;BMS RIGHT OF FIRST NEGOTIATION&#8221; means the rights granted to BMS<br \/>\npursuant to Section 3.6 of the Commercial Arrangements.<\/p>\n<p>         &#8220;BMS RIGHT OF FIRST OFFER&#8221; means the rights granted to BMS pursuant to<br \/>\nSection 3.5 of the Commercial Arrangements.<\/p>\n<p>         &#8220;BMS SELL-DOWN&#8221; means a direct or indirect transfer, sale or other<br \/>\ndisposition by BMS or any of its Affiliates of shares of Common Stock<br \/>\n(including, without limitation, any pledge of or encumbrance on shares of Common<br \/>\nStock) or any Hedging Transaction entered into by BMS or any of its Affiliates,<br \/>\nthe result of which is that BMS and its Affiliates own or have voting power over<br \/>\nless than, or have reduced their economic exposure to less than the equivalent<br \/>\nof, 75% of the maximum number of shares of Common Stock beneficially owned by<br \/>\nBMS and its Affiliates at any time from the Effective Time through the time<br \/>\nimmediately prior to such transfer, sale or other disposition or transaction.<\/p>\n<p>         &#8220;BMS&#8217; BENEFICIAL INTEREST&#8221; means, for any date, the percentage of<br \/>\nCommon Stock, determined on the basis of the number of shares of Common Stock<br \/>\nthen outstanding (i.e., determined on a primary basis), that is beneficially<br \/>\nowned by BMS on such date.<\/p>\n<p>                                       2<\/p>\n<p>         &#8220;BMS&#8217; COMMON STOCK INTEREST&#8221; means, for any date, the percentage of (i)<br \/>\nshares of outstanding Common Stock owned by BMS and its Affiliates on such date<br \/>\nand over which BMS or any of its Affiliates exercises full voting control and<br \/>\nbears the full economic risk, plus any shares of Common Stock with respect to<br \/>\nwhich BMS has delivered a BMS Dilution Option Exercise Notice but which the<br \/>\nEquity Holding Entity has not yet acquired; PROVIDED that if BMS does not pay<br \/>\nthe purchase price for shares of Common Stock for which it has delivered a BMS<br \/>\nDilution Option Exercise Notice in accordance with the provisions of Section<br \/>\n3.04 of this Agreement, then such shares will not be included in such<br \/>\ncalculation, to (ii) the total number of shares of Common Stock then outstanding<br \/>\n(i.e., determined on a primary basis).<\/p>\n<p>         &#8220;BMS&#8217; ENDING DILUTION PERIOD INTEREST&#8221; means, with respect to any<br \/>\nDilution Period, the BMS Common Stock Interest as of the last day of such<br \/>\nDilution Period.<\/p>\n<p>         &#8220;BMS&#8217; GREATEST DILUTION PERIOD INTEREST&#8221; means, with respect to any<br \/>\nDilution Period, the percentage equivalent of the Net Fraction which is the<br \/>\ngreatest (but in any event not greater than the Standstill Interest) on any day<br \/>\nduring the applicable Dilution Period. The &#8220;NET FRACTION&#8221; for any day shall be<br \/>\nequal to the fraction set forth in clause (a) below less each fraction set forth<br \/>\nin clause (b) below:<\/p>\n<p>         (a) the fraction<\/p>\n<p>                  (i) the numerator of which is the sum of (w) the number of<br \/>\n         shares of outstanding Common Stock owned by the Equity Holding Entity<br \/>\n         at such date (the &#8220;DETERMINATION DATE&#8221;) and over which the Equity<br \/>\n         Holding Entity exercised full voting control and bore the full economic<br \/>\n         risk as of the Determination Date and (x) any shares with respect to<br \/>\n         which at the Determination Date either (A) a previous BMS Dilution<br \/>\n         Option may be, but has not been, exercised by BMS (whether or not the<br \/>\n         Company shall have provided a Dilution Notice to BMS with respect to<br \/>\n         such previous BMS Dilution Option), if any, or (B) a previous BMS<br \/>\n         Dilution Option has been exercised by BMS but the shares subject to<br \/>\n         such BMS Dilution Option shall not have been purchased by the Equity<br \/>\n         Holding Entity, if any; PROVIDED that, in the case of clause (A), if<br \/>\n         BMS does not exercise such previous BMS Dilution Option on or prior to<br \/>\n         the thirtieth day after receipt from the Company of the Dilution Notice<br \/>\n         with respect to such previous BMS Dilution Option, or, in the case of<br \/>\n         clauses (A) and (B), BMS shall have exercised such previous BMS<br \/>\n         Dilution Option but the Equity Holding Entity shall have failed to<br \/>\n         purchase such shares in accordance<\/p>\n<p>                                       3<\/p>\n<p>         with the provisions of Section 3.04(e), such shares shall not be<br \/>\n         included in such calculation; and<\/p>\n<p>         (ii) the denominator of which is the sum of (y) the total number of<br \/>\n         shares of Common Stock outstanding (i.e., determined on a primary<br \/>\n         basis) as of the Determination Date and (z) any shares included in the<br \/>\n         calculation of the numerator pursuant to clause (i)(x) above, if any,<br \/>\n         LESS,<\/p>\n<p>         (b) for each sale, transfer or other disposition (including, without<br \/>\nlimitation, any pledge of or encumbrance on shares of Common Stock) or Hedging<br \/>\nTransaction entered into by the Equity Holding Entity, in each case, which is<br \/>\nconsummated or entered into after the Determination Date, the fraction<\/p>\n<p>                  (i) the numerator of which is the number of shares sold,<br \/>\n         transferred or otherwise disposed of or subject to such Hedging<br \/>\n         Transaction, and<\/p>\n<p>                  (ii) the denominator of which is the total number of shares of<br \/>\n         Common Stock outstanding at the time of such sale, transfer,<br \/>\n         disposition or Hedging Transaction.<\/p>\n<p>         A Person shall be deemed to &#8220;BENEFICIALLY OWN&#8221;, and shall be deemed the<br \/>\n&#8220;BENEFICIAL OWNER&#8221; of, any securities:<\/p>\n<p>                  (a) which such Person or any of its Affiliates, directly or<br \/>\n         indirectly, beneficially owns (as determined pursuant to Rule 13d-3<br \/>\n         under the Exchange Act as in effect on the date hereof);<\/p>\n<p>                  (b) which such Person or any of its Affiliates, directly or<br \/>\n         indirectly, has:<\/p>\n<p>                           (i) the right to acquire (whether such right is<br \/>\n                  exercisable immediately or only upon the occurrence of certain<br \/>\n                  events or the passage of time or both) pursuant to any<br \/>\n                  agreement, arrangement or understanding (whether or not in<br \/>\n                  writing) or otherwise; PROVIDED that shares of Common Stock<br \/>\n                  that the Equity Holding Entity may acquire pursuant to the BMS<br \/>\n                  Dilution Option shall not be deemed beneficially owned by the<br \/>\n                  Equity Holding Entity until BMS shall have delivered a BMS<br \/>\n                  Dilution Option Exercise Notice with respect to such shares;<br \/>\n                  or<\/p>\n<p>                           (ii) the right to vote (whether such right is<br \/>\n                  exercisable immediately or only upon the occurrence of certain<br \/>\n                  events or the<\/p>\n<p>                                       4<\/p>\n<p>                  passage of time or both) pursuant to any agreement,<br \/>\n                  arrangement or understanding (whether or not in writing) or<br \/>\n                  otherwise; PROVIDED that a Person shall not be deemed to<br \/>\n                  &#8220;beneficially own&#8221; or be the &#8220;beneficial owner&#8221; of any<br \/>\n                  security under this clause (ii) as a result of an agreement,<br \/>\n                  arrangement or understanding to vote such security if such<br \/>\n                  agreement, arrangement or understanding (A) arises solely from<br \/>\n                  a revocable proxy or consent given in response to a public<br \/>\n                  proxy or consent solicitation made pursuant to, and in<br \/>\n                  accordance with, the applicable rules and regulations under<br \/>\n                  the Exchange Act and (B) is not also then reportable by such<br \/>\n                  Person on Schedule 13D under the Exchange Act (or any<br \/>\n                  comparable or successor report); or<\/p>\n<p>                  (c) which are beneficially owned, directly or indirectly, by<br \/>\n         any other Person (or any Affiliate thereof) with which such Person or<br \/>\n         any of its Affiliates has any agreement, arrangement or understanding<br \/>\n         (whether or not in writing) for the purpose of acquiring, holding,<br \/>\n         voting (except pursuant to a revocable proxy as described in<br \/>\n         subparagraph(b)(ii) immediately above) or disposing of any such<br \/>\n         securities;<\/p>\n<p>         PROVIDED that neither the Company nor any of its Subsidiaries shall be<br \/>\n         deemed Affiliates of BMS for purposes of this definition.<\/p>\n<p>         &#8220;BOARD&#8221; or &#8220;BOARD OF DIRECTORS&#8221; means the Board of Directors of the<br \/>\nCompany, except where the context requires otherwise.<\/p>\n<p>         &#8220;BUSINESS DAY&#8221; means any day except a Saturday, Sunday or other day on<br \/>\nwhich commercial banks in the City of New York are authorized by law to close.<\/p>\n<p>         &#8220;CODE&#8221; means the Internal Revenue Code of 1986.<\/p>\n<p>         &#8220;COMMON STOCK&#8221; means the common stock, $.001 par value, of the Company.<\/p>\n<p>         &#8220;COMMON STOCK EQUIVALENTS&#8221; means any securities of the Company<br \/>\nexercisable or exchangeable for or convertible into shares of Common Stock,<br \/>\nwhether exercisable, exchangeable or convertible immediately or only upon the<br \/>\noccurrence of certain events or the passage of time or both.<\/p>\n<p>         &#8220;COMPANY AGGREGATE VALUE&#8221; means, for any date, the aggregate market<br \/>\ncapitalization of the Company plus the aggregate indebtedness of the Company<br \/>\nplus the fair value of any outstanding preferred stock of the Company.<\/p>\n<p>                                       5<\/p>\n<p>         &#8220;COMPANY AVERAGE CLOSING PRICE&#8221; means the average closing price of the<br \/>\nCommon Stock on the Nasdaq for the thirty Nasdaq trading days ending on and<br \/>\nincluding the date which is the fifth Nasdaq trading day prior to the date on<br \/>\nwhich the existence of any Complying Proposal is made public.<\/p>\n<p>         &#8220;COMPLYING PROPOSAL&#8221; means a proposal by BMS to acquire all, but not<br \/>\nless than all, of the then-outstanding shares of Common Stock and Common Stock<br \/>\nEquivalents not owned by the Equity Holding Entity for a price or consideration<br \/>\nper share not less than 125% of the Company Average Closing Price, the<br \/>\nconsideration for which may be cash or common stock of BMS; PROVIDED that if BMS<br \/>\nproposes consideration in the form of BMS common stock, in whole or in part,<br \/>\nthen (i) upon issuance to holders of Common Stock and Common Stock Equivalents,<br \/>\nsuch common stock of BMS shall be listed on the same securities exchanges as all<br \/>\nother outstanding common stock of BMS, and (ii) the acquisition shall be<br \/>\nstructured so as to qualify as a &#8220;reorganization&#8221; under Section 368 of the Code<br \/>\nor as an exchange described in Section 351 of the Code or any successor<br \/>\nprovision thereto or any other provision of the Code which would enable the<br \/>\nacquisition to be tax-free to the Company&#8217;s stockholders.<\/p>\n<p>         &#8220;DETERMINATION DATE&#8221; has the meaning set forth in the definition of<br \/>\n&#8220;BMS&#8217; Greatest Dilution Period Interest&#8221;.<\/p>\n<p>         &#8220;DIRECTOR&#8221; means a member of the Board of Directors.<\/p>\n<p>         &#8220;DILUTION REFERENCE DATE&#8221; means any (i) Annual Dilution Reference Date,<br \/>\n(ii) Exceptional Stock Issuance Date or (iii) Rights-Reducing Stock Issuance<br \/>\nDate.<\/p>\n<p>         &#8220;DILUTION PERIOD&#8221; means (i) with respect to the initial Dilution<br \/>\nPeriod, the period beginning on the Effective Time and ending upon the first<br \/>\nDilution Reference Date thereafter and (ii) with respect to all subsequent<br \/>\nDilution Periods, the period beginning on the day following the immediately<br \/>\npreceding Dilution Reference Date and ending on the immediately following<br \/>\nDilution Reference Date.<\/p>\n<p>         &#8220;EFFECTIVE TIME&#8221; means the time of the Closing (as defined in the<br \/>\nAcquisition Agreement), unless &#8220;Closing&#8221; is defined by clause (iv) of the<br \/>\ndefinition of Closing, in which case &#8220;Effective Time&#8221; shall mean the date on<br \/>\nwhich BMS&#8217; Common Stock Interest is first equal to or greater than 5%.<\/p>\n<p>         &#8220;EQUITY HOLDING ENTITY&#8221; means Acquisition Sub or, upon any transfer by<br \/>\nAcquisition Sub pursuant to Section 4.01(d) of the shares of Common Stock<\/p>\n<p>                                       6<\/p>\n<p>owned by Acquisition Sub, the transferee of Acquisition Sub (or, upon any<br \/>\nsubsequent transfer pursuant to Section 4.01(d), the transferee of such<br \/>\ntransferee).<\/p>\n<p>         &#8220;EXCHANGE ACT&#8221; means the Securities Exchange Act of 1934.<\/p>\n<p>         &#8220;FIRST COMMERCIAL SALE&#8221; has the meaning set forth in the Commercial<br \/>\nArrangements.<\/p>\n<p>         &#8220;HEDGING TRANSACTION&#8221; means any forward, futures, swap, call, put,<br \/>\nshort sale or other hedging arrangement entered into by any Person or any of its<br \/>\nAffiliates that transfers all or a portion of the economic risk or benefit<br \/>\nassociated with the ownership of Common Stock.<\/p>\n<p>         &#8220;HSR ACT&#8221; means the Hart-Scott-Rodino Antitrust Improvements Act of<br \/>\n1976.<\/p>\n<p>         &#8220;INITIAL ACQUISITION&#8221; means the acquisition by Acquisition Sub of<br \/>\nshares of Common Stock pursuant to (i) the Offer and, if consummated, the<br \/>\nAdditional Share Issuance, (ii) the Market Failure Share Issuance, or (iii) the<br \/>\nOpen Market Purchase and, if consummated, the Open Market Top-Up Share Issuance<br \/>\n(as such terms are defined in the Acquisition Agreement).<\/p>\n<p>         &#8220;INITIAL TRIGGER DATE&#8221; means the later to occur of (i) the date which<br \/>\nis the third anniversary of the Signing Date, and (ii) the date which is the<br \/>\nsecond anniversary of the First Commercial Sale; PROVIDED that if the date<br \/>\nreferred to in clause (ii) occurs after the date which is forty-two months after<br \/>\nthe Signing Date, the Initial Trigger Date shall be the date which is forty-two<br \/>\nmonths after the Signing Date.<\/p>\n<p>         &#8220;INSTITUTIONAL PURCHASER&#8221; means a Person described in Rule 13d-1(b)(1)<br \/>\npromulgated under the Exchange Act (other than any such Person who acquires<br \/>\nCommon Stock as part of such Person&#8217;s market-making or broker-dealer<br \/>\nactivities).<\/p>\n<p>         &#8220;MERCK AGREEMENT&#8221; means the Development and License Agreement, dated<br \/>\nDecember 14, 1998, between the Company and Merck KgaA, as amended and modified<br \/>\nas of the date of this Agreement.<\/p>\n<p>         &#8220;NASDAQ&#8221; means the National Association of Securities Dealers<br \/>\nAutomated Quotation System.<\/p>\n<p>         &#8220;NET FRACTION&#8221; has the meaning set forth in the definition of &#8220;BMS&#8217;<br \/>\nGreatest Dilution Period Interest&#8221;.<\/p>\n<p>                                       7<\/p>\n<p>         &#8220;OUTSTANDING CONVERTIBLE SECURITIES&#8221; means (a) any securities of the<br \/>\nCompany outstanding as of September 18, 2001 that are convertible into or<br \/>\nexercisable or exchangeable for shares of Common Stock, and any options or other<br \/>\nrights to acquire from the Company or other obligation of the Company to issue,<br \/>\nshares of Common Stock, in each case outstanding or existing as of September 18,<br \/>\n2001, including without limitation shares issuable (A) to Merck KGaA pursuant to<br \/>\nthe Merck Agreement, (B) as a result of the exercise of options or warrants<br \/>\noutstanding as of September 18, 2001, (C) upon conversion of the Company&#8217;s<br \/>\noutstanding 5 1\/2% Convertible Notes due March 1, 2005, or (D) pursuant to the<br \/>\nCompany&#8217;s employee stock purchase plan, and (b) any shares issued after<br \/>\nSeptember 18, 2001 in connection with any hiring, retention, compensation,<br \/>\nincentivization, retirement, termination or severance arrangements for<br \/>\nemployees, officers, directors and consultants of the Company and its<br \/>\nAffiliates, whether or not the obligation exists as of September 18, 2001, and<br \/>\nany option, stock award or warrant issued in the ordinary course of business.<\/p>\n<p>         &#8220;PERSON&#8221; means an individual or a corporation, partnership,<br \/>\nassociation, trust, or any other entity or organization, including a government<br \/>\nor political subdivision or an agency or instrumentality thereof.<\/p>\n<p>         &#8220;REGISTRABLE SECURITIES&#8221; means all shares of Common Stock held by the<br \/>\nEquity Holding Entity; PROVIDED, that such securities shall cease to be<br \/>\nRegistrable Securities when (i) a registration statement relating to such<br \/>\nsecurities shall have been declared effective by the SEC and such securities<br \/>\nshall have been disposed of pursuant to such registration statement, or (ii)<br \/>\nsuch securities have been disposed of pursuant to Rule 144 promulgated under the<br \/>\nSecurities Act or may be disposed of pursuant to Rule 144(k) promulgated under<br \/>\nthe Securities Act.<\/p>\n<p>         &#8220;RESTRICTED PERIOD&#8221; means the period from the Signing Date until the<br \/>\nearliest to occur of (i) the fifth anniversary of the Signing Date, (ii) a BMS<br \/>\nDilution Event, (iii) a BMS Sell-Down, (iv) the consummation of a Third-Party<br \/>\nChange of Control Transaction, (v) a termination of the Commercial Arrangements<br \/>\nby BMS pursuant to Section 13.3 of the Commercial Arrangements, or (vi) a<br \/>\ntermination of the Commercial Arrangements by the Company pursuant to Section<br \/>\n13.2 of the Commercial Arrangements.<\/p>\n<p>         &#8220;SEC&#8221; means the Securities and Exchange Commission.<\/p>\n<p>         &#8220;SECURITIES ACT&#8221; means the Securities Act of 1933.<\/p>\n<p>         &#8220;SIGNING DATE&#8221; means the date of this Agreement.<\/p>\n<p>                                       8<\/p>\n<p>         &#8220;STANDSTILL INTEREST&#8221; means, for any date, 19.9% of the<br \/>\nthen-outstanding shares of Common Stock.<\/p>\n<p>         &#8220;STANDSTILL PERIOD&#8221; means the period from the Signing Date until the<br \/>\nStandstill Termination Date.<\/p>\n<p>         &#8220;STANDSTILL TERMINATION DATE&#8221; means the earliest to occur of: (i) the<br \/>\ndate which is the fifth anniversary of the Signing Date; (ii) the date on which<br \/>\na Third- Party Change of Control Transaction is consummated; (iii) the first<br \/>\nanniversary of a BMS Dilution Event; and (iv) the date on which a Prohibited<br \/>\nAction is taken by the Company during the Restricted Period without the consent<br \/>\nof the BMS Directors.<\/p>\n<p>         &#8220;SUBSIDIARY&#8221; means, with respect to any Person, any corporation or<br \/>\nother entity of which a majority of the capital stock or other ownership<br \/>\ninterests having ordinary voting power to elect a majority of the board of<br \/>\ndirectors or other persons performing similar functions are at the time directly<br \/>\nor indirectly owned by such Person.<\/p>\n<p>         &#8220;THIRD-PARTY CHANGE OF CONTROL TRANSACTION&#8221; means an acquisition of<br \/>\nbeneficial ownership of more than 35% of the outstanding Common Stock by a<br \/>\nthird-party other than BMS or any Affiliate of BMS.<\/p>\n<p>         &#8220;UNDERWRITER&#8221; means a securities dealer who purchases any Registrable<br \/>\nSecurities as a principal in connection with a distribution of such Registrable<br \/>\nSecurities and not as part of such dealer&#8217;s market-making activities.<\/p>\n<p>         Any reference in this Agreement to a statute shall be to such statute,<br \/>\nas amended from time to time, and to the rules and regulations promulgated<br \/>\nthereunder.<\/p>\n<p>         (b) Each of the following terms is defined in the Section set forth<br \/>\nopposite each term:<\/p>\n<table>\n<caption>\nTERM                                                      SECTION<br \/>\n&#8212;-                                                      &#8212;&#8212;-<br \/>\n<s>                                                       <c><br \/>\nAcquisition Agreement&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  Recitals<br \/>\nAcquisition Sub&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  Preamble<br \/>\nAnnual Dilution Reference Date&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  3.04<br \/>\nBMS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  Preamble<br \/>\nBMS Dilution Option&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  3.04<br \/>\nBMS Dilution Option Exercise Notice&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;  3.04<br \/>\nBMS Dilution Option Shares&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;  3.04<\/p>\n<p>                                       9<\/p>\n<caption>\nTERM                                                      SECTION<br \/>\n&#8212;-                                                      &#8212;&#8212;-<br \/>\n<s>                                                       <c><br \/>\nBMS Schedule 13D&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  3.04<br \/>\nCommercial Arrangements&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;  Recitals<br \/>\nCompany&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  Preamble<br \/>\nDemand Registration&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  5.01<br \/>\nDilution Notice&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  3.04<br \/>\nERS&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  Recitals<br \/>\nExceptional Stock Issuance Date&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  3.04<br \/>\nInspectors&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  5.04<br \/>\nOverall Dilution Option Period&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  3.04<br \/>\nPiggyback Registration&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  5.02<br \/>\nProhibited Actions&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  2.04<br \/>\nRecords&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  5.04<br \/>\nRegistration Expenses&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;..  5.07<br \/>\nRegistration Statement&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.  5.01<br \/>\nRights-Reducing Stock Issuance Date&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;  3.04<br \/>\n<\/c><\/s><\/caption>\n<p><\/c><\/s><\/caption>\n<\/table>\n<p>                                    ARTICLE 2<br \/>\n                              CORPORATE GOVERNANCE<\/p>\n<p>         SECTION 2.01. COMPOSITION OF THE BOARD OF DIRECTORS. (a) The number of<br \/>\ndirectors comprising the Board of Directors immediately after the Effective Time<br \/>\nshall be increased to twelve.<\/p>\n<p>          (b) Immediately after the Effective Time, the Company shall cause to<br \/>\nbe appointed to its Board of Directors two individuals to be designated by BMS<br \/>\nprior to the Effective Time, which individuals shall serve as BMS Directors in<br \/>\naccordance with the terms of this Section 2.01; PROVIDED that (i) if immediately<br \/>\nafter the Effective Time, BMS has the right to nominate only one BMS Director<br \/>\npursuant to this Section 2.01, the Company shall cause one individual designated<br \/>\nby BMS to be appointed to its Board of Directors, and such individual shall<br \/>\nserve as a BMS Director in accordance with the terms of this Section 2.01, and<br \/>\n(ii) if immediately after the Effective Time, BMS has no right to designate a<br \/>\nBMS Director pursuant to this Section 2.01, the Board shall not be required to<br \/>\ncause the appointment of any individual to the Board as a BMS Director. Subject<br \/>\nto the other provisions of this Section 2.01, such BMS Directors shall remain in<br \/>\noffice until the next election of directors (or any earlier termination,<br \/>\nresignation or removal). Following the Effective Time, all Directors in office<br \/>\nimmediately prior to the Effective Time shall remain in office until the next<br \/>\nelection of directors (or any earlier termination, resignation or removal).<\/p>\n<p>                                       10<\/p>\n<p>          (c) Except as otherwise provided herein, at all times from and after<br \/>\nthe Effective Time, but subject to Section 2.01(d), BMS shall have the right to<br \/>\ndesignate two BMS Directors for election at each annual meeting of the Company&#8217;s<br \/>\nstockholders. Any individual designated by BMS to serve as a BMS Director<br \/>\npursuant to this Section 2.01 shall be a senior officer or director of BMS. Each<br \/>\nindividual so designated shall, subject to applicable law, be recommended by the<br \/>\nBoard for election to the Board by the Company&#8217;s stockholders.<\/p>\n<p>          (d) At all times from and after the Effective Time, if the Board is<br \/>\ncomprised of twelve members, BMS will have the right to have the Company<br \/>\nnominate two BMS Directors; PROVIDED that if at any time BMS&#8217; Common Stock<br \/>\nInterest is less than 12.5% for a period of forty-five consecutive calendar<br \/>\ndays, thereafter BMS will only have the right to have the Company nominate one<br \/>\nBMS Director until such time as BMS&#8217; Common Stock Interest is 12.5% or greater.<br \/>\nIn the event that the number of Directors is increased from twelve during any<br \/>\nperiod in which BMS has the right to have the Company nominate at least one BMS<br \/>\nDirector pursuant to this Section 2.01, BMS shall be entitled to designate a<br \/>\nnumber of BMS Directors equal to (i) the lesser of (A) BMS&#8217; Common Stock<br \/>\nInterest or (B) the Standstill Interest, multiplied by (ii) the total number of<br \/>\nDirectors (rounded down to next lowest whole number in the case of fractions<br \/>\nless than .5 and rounded up to the next highest whole number in the case of<br \/>\nfractions of .5 or greater). Notwithstanding the foregoing, if the Company has<br \/>\nterminated the Commercial Arrangements pursuant to Section 13.2 of the<br \/>\nCommercial Arrangements, BMS shall have no right to have the Company nominate a<br \/>\nBMS Director, regardless of BMS&#8217; Common Stock Interest.<\/p>\n<p>          (e) Subject to applicable law, in the event that at any time after the<br \/>\nEffective Time, the number of BMS Directors differs from the number of Directors<br \/>\nthat BMS has the right to designate pursuant to this Section 2.01, (i) if the<br \/>\nnumber of BMS Directors exceeds such number, BMS shall promptly cause to resign,<br \/>\nand take all other action reasonably necessary to cause the prompt removal of,<br \/>\nthat number of BMS Directors as required to make the remaining number of BMS<br \/>\nDirectors conform to the number of BMS Directors that BMS has the right to<br \/>\nnominate pursuant to this Section 2.01 and (ii) if the number of BMS Directors<br \/>\nis less than such number, the Company shall promptly take all necessary action<br \/>\nto create sufficient vacancies on the Board of Directors to permit BMS to<br \/>\ndesignate the full number of BMS Directors which it is entitled to designate<br \/>\npursuant to this Section 2.01 (such action to include expanding the size of the<br \/>\nBoard of Directors or seeking the resignation or removal of Directors). The<br \/>\nCompany shall have the right to designate replacement Directors for the BMS<br \/>\nDirectors removed in accordance with clause (i) of the preceding sentence and<br \/>\nupon the creation of any vacancy pursuant to clause (ii) of the preceding<br \/>\nsentence BMS shall designate the<\/p>\n<p>                                       11<\/p>\n<p>person to fill such vacancy in accordance with this Section 2.01 and, subject to<br \/>\napplicable law, the Board of Directors shall appoint each person so designated.<\/p>\n<p>          (f) BMS shall have the right to designate any replacement for a BMS<br \/>\nDirector designated in accordance with this Section 2.01 by BMS at the<br \/>\ntermination of such Director&#8217;s term or upon death, resignation, retirement,<br \/>\ndisqualification, removal from office or other cause. Subject to applicable law,<br \/>\nthe Board of Directors shall appoint each person so designated.<\/p>\n<p>          (g) Notwithstanding anything in this Agreement to the contrary, the<br \/>\nprovisions of Sections 2.01(a), (b), (c), (d) and (f) shall terminate<br \/>\nimmediately and have no further force or effect upon the occurrence of a BMS<br \/>\nDilution Event.<\/p>\n<p>         SECTION 2.02. SOLICITATION AND VOTING OF SHARES. (a) The Company shall<br \/>\nuse all reasonable efforts to solicit from the stockholders of the Company<br \/>\neligible to vote for the election of Directors proxies in favor of the nominees<br \/>\ndesignated in accordance with Section 2.01; it being understood and agreed that<br \/>\nthe Company shall have satisfied its obligation under this Section 2.02(a) if it<br \/>\nuses the same efforts to solicit consents in favor of the nominees designated by<br \/>\nBMS as it uses to solicit consents in favor of all other nominees for the Board.<\/p>\n<p>          (b) During the period in which BMS has the right to have the Company<br \/>\nnominate at least one BMS Director pursuant to Section 2.01, in any election of<br \/>\nDirectors or in any meeting of the stockholders of the Company called expressly<br \/>\nfor the removal of Directors (or any action by written consent for such<br \/>\npurposes), BMS, the Equity Holding Entity and all other Affiliates of BMS shall<br \/>\nvote all of their shares of Common Stock as follows: (i) with respect to BMS<br \/>\nDirectors, as BMS and its Affiliates shall determine, and (ii) with respect to<br \/>\nall remaining Directors, in the same proportion as the votes cast (whether for,<br \/>\nagainst or abstaining) by all stockholders of the Company (other than BMS and<br \/>\nits Affiliates).<\/p>\n<p>          (c) BMS shall cause all shares of Common Stock beneficially owned by<br \/>\nit to be represented, in person or by proxy, at all meetings of the Company&#8217;s<br \/>\nstockholders, so that such shares of Common Stock may be counted for the purpose<br \/>\nof determining the presence of a quorum at such meetings.<\/p>\n<p>         SECTION 2.03. COMMITTEES OF THE BOARD OF DIRECTORS. Subject to<br \/>\napplicable law, during the period in which (i) BMS has the right to have the<br \/>\nCompany nominate at least one BMS Director pursuant to Section 2.01 and (ii) at<br \/>\nleast one BMS Director is a member of the Board, one of the members of each<br \/>\ncommittee of the Board (other than any committee or committees of the Board<br \/>\nwhose mandate is limited to consideration of matters relating to (i) the<br \/>\nCompany&#8217;s<\/p>\n<p>                                       12<\/p>\n<p>relationship with BMS, (ii) any transaction with BMS, or (iii) any Third-Party<br \/>\nChange of Control Transaction) shall be a BMS Director. Committees of the Board<br \/>\nmay consist of any number of members, as determined by the Board. Where<br \/>\napplicable, each BMS Director serving on a committee of the Board shall satisfy<br \/>\nindependent director criteria in order to be eligible to serve on such<br \/>\ncommittee. Each committee of the Board will hold regularly scheduled meetings<br \/>\nand each member of a committee shall receive reasonable prior notice of and may<br \/>\nattend in person or by telephone any regular or special committee meeting.<\/p>\n<p>         SECTION 2.04. BMS APPROVAL REQUIRED FOR CERTAIN ACTIONS. During the<br \/>\nRestricted Period, the Company will not do any of the following (each, a<br \/>\n&#8220;PROHIBITED ACTION&#8221;) without the consent of the BMS Directors:<\/p>\n<p>          (a) Issue Common Stock (or securities convertible into, or exercisable<br \/>\nor exchangeable for, Common Stock) in excess of 21,473,002 shares in the<br \/>\naggregate, subject to appropriate adjustment for any stock split, reverse stock<br \/>\nsplit or other similar transactions; PROVIDED that for purposes of this<br \/>\nparagraph (a), the issuance of options and other securities convertible into, or<br \/>\nexercisable or exchangeable for, Common Stock will be deemed issuances of shares<br \/>\nof Common Stock (in the amount of shares into which such securities are<br \/>\nexercisable, convertible or exchangeable) at the time such options and other<br \/>\nsecurities are issued, and the subsequent issuance of Common Stock upon the<br \/>\nexercise, conversion or exchange thereof shall not be subject to the limitations<br \/>\nset forth in this paragraph (a); PROVIDED further that the following shall not<br \/>\nbe subject to the limitations set forth in this paragraph (a):<\/p>\n<p>                  (i) the issuance of Common Stock (or securities convertible<br \/>\n         into, or exercisable or exchangeable for, Common Stock) in connection<br \/>\n         with any acquisition that is otherwise permitted under Section 2.04(c)<br \/>\n         below,<\/p>\n<p>                  (ii) the issuance of Common Stock upon the conversion,<br \/>\n         exercise or exchange of options and other securities convertible into,<br \/>\n         or exercisable or exchangeable for, Common Stock outstanding as of the<br \/>\n         close of business on the Signing Date,<\/p>\n<p>                  (iii) the issuance of Common Stock (or securities convertible<br \/>\n         into, or exercisable or exchangeable for, Common Stock) on a PRO RATA<br \/>\n         basis to all stockholders of the Company; and<\/p>\n<p>                  (iv) the issuance of any capital stock of the Company pursuant<br \/>\n         to the Merck Agreement, the Acquisition Agreement or Section 3.04 of<br \/>\n         this Agreement;<\/p>\n<p>                                       13<\/p>\n<p>         (b) Incur any indebtedness for borrowed money or issue any preferred<br \/>\nstock if the total of (i) the principal amount of indebtedness incurred since<br \/>\nthe Signing Date and then-outstanding, and (ii) the net proceeds from the<br \/>\nissuance after September 18, 2001 of any redeemable preferred stock<br \/>\nthen-outstanding would exceed the amount of indebtedness for borrowed money<br \/>\noutstanding as of the Signing Date by more than $500 million; PROVIDED that, in<br \/>\nthe case of any indebtedness issued at a discount to its face value of greater<br \/>\nthan 5%, for the purposes of this paragraph (b), the principal amount of such<br \/>\nindebtedness will be the gross proceeds received by the Company from such<br \/>\nissuance; and PROVIDED further that the following shall not be subject to the<br \/>\nlimitations set forth in this paragraph (b):<\/p>\n<p>                  (i) indebtedness for borrowed money incurred in connection<br \/>\n         with any acquisition that is otherwise permitted under Section 2.04(c)<br \/>\n         below;<\/p>\n<p>                  (ii) inter-company indebtedness, including (i) indebtedness<br \/>\n         between the Company and any of its wholly-owned Subsidiaries, and (ii)<br \/>\n         indebtedness between any wholly-owned Subsidiaries of the Company; and<\/p>\n<p>                  (iii) the issuance of any capital stock of the Company<br \/>\n         pursuant to the Merck Agreement;<\/p>\n<p>         (c) Acquire any business, the aggregate consideration for which, when<br \/>\ntaken together with the aggregate consideration for all other such acquisitions<br \/>\nconsummated during the previous twelve months (it being acknowledged and agreed<br \/>\nthat the calculation of aggregate consideration under this paragraph (c) shall<br \/>\ninclude any assumption of indebtedness in connection with any such acquisition),<br \/>\nis in excess of 25% of the Company Aggregate Value at the time the Company<br \/>\nenters into the binding agreement relating to such acquisition;<\/p>\n<p>         (d) Enter into any non-competition agreement which would be binding on<br \/>\nBMS or its Affiliates or any BMS Director, either at the time entered into or at<br \/>\nthe time at which BMS acquires, directly or indirectly, 100% of the outstanding<br \/>\nCommon Stock;<\/p>\n<p>         (e) Dispose of all or any substantial portion of the non-cash assets of<br \/>\nthe Company, PROVIDED that any licensing, product development or marketing<br \/>\narrangement entered into after the Company has complied with the BMS Right of<br \/>\nFirst Offer or the BMS Right of First Negotiation, as applicable, shall not be<br \/>\nsubject to this limitation;<\/p>\n<p>                                       14<\/p>\n<p>         (f) Enter into any transaction or adopt any corporate action (including<br \/>\nany amendment to the Company&#8217;s certificate of incorporation or by-laws (other<br \/>\nthan those amendments approved by the Company&#8217;s stockholders which are not<br \/>\nrecommended by the Board)), other than those contemplated by this Agreement, the<br \/>\nAcquisition Agreement or the Commercial Arrangements and other than those<br \/>\nimposed on each other holder of Common Stock, which would (i) impose limitations<br \/>\non the legal rights of BMS or any of its Affiliates as a stockholder of the<br \/>\nCompany, (ii) deny any benefit to BMS or any of its Affiliates, proportionately<br \/>\nas a holder of Common Stock, that is made available to other holders of Common<br \/>\nStock, or (iii) otherwise materially adversely discriminate against BMS or any<br \/>\nof its Affiliates as a stockholder of the Company; and<\/p>\n<p>         (g) Issue shares of any class of capital stock with more than one vote<br \/>\nper share, other than any class of stock (i) the shares of which are convertible<br \/>\ninto Common Stock, and (ii) for which the number of votes per share of such<br \/>\nclass does not exceed the number of votes per share of the class of stock into<br \/>\nwhich it is convertible.<\/p>\n<p>                                    ARTICLE 3<br \/>\n          LIMITATIONS ON ADDITIONAL PURCHASES OF COMMON STOCK AND OTHER<br \/>\n                                     ACTIONS<\/p>\n<p>         SECTION 3.01. PURCHASES OF COMMON STOCK. Except for the acquisition of<br \/>\nshares of Common Stock pursuant to the Acquisition Agreement, subject to the<br \/>\nexceptions set forth in Section 3.03, during the Standstill Period, BMS and the<br \/>\nEquity Holding Entity shall not, and BMS shall not permit its Affiliates to,<br \/>\ndirectly or indirectly, acquire or make a proposal to acquire beneficial<br \/>\nownership of any shares of Common Stock from the Company or any other person or<br \/>\nentity.<\/p>\n<p>         SECTION 3.02. ADDITIONAL LIMITATIONS. Subject to the exceptions set<br \/>\nforth in Section 3.03, during the Standstill Period, BMS and the Equity Holding<br \/>\nEntity shall not, and BMS shall not permit its Affiliates to:<\/p>\n<p>         (a) make, or take any action to solicit, initiate or encourage, any<br \/>\noffer or proposal for, or any indication of interest in, a merger or other<br \/>\nbusiness combination involving the Company or any Subsidiary of the Company or<br \/>\nthe acquisition of any equity interest in, or a substantial portion of the<br \/>\nassets of, the Company or any Subsidiary of the Company;<\/p>\n<p>         (b) &#8220;solicit&#8221;, or become a &#8220;participant&#8221; in any &#8220;solicitation&#8221; of, any<br \/>\n&#8220;proxy&#8221; (as such terms are defined in Regulation 14A under the Exchange Act)<\/p>\n<p>                                       15<\/p>\n<p>from any holder of Common Stock in connection with any vote on any matter, or<br \/>\nagree or announce its intention to vote with any Person undertaking a<br \/>\n&#8220;solicitation&#8221;;<\/p>\n<p>         (c) form, join or in any way participate in a &#8220;group&#8221; (within the<br \/>\nmeaning of Section 13(d)(3) of the Exchange Act) with respect to any Common<br \/>\nStock;<\/p>\n<p>         (d) grant any proxies with respect to any Common Stock to any Person<br \/>\n(other than as recommended by the Board) or deposit any Common Stock in a voting<br \/>\ntrust or enter into any other arrangement or agreement with respect to the<br \/>\nvoting thereof; or<\/p>\n<p>         (e) request, propose or otherwise seek any amendment or waiver of the<br \/>\nprovisions of Article 3.<\/p>\n<p>         SECTION 3.03. STANDSTILL EXCEPTIONS. (a) Notwithstanding Sections 3.01<br \/>\nand 3.02, but subject to the provisions of Section 3.03(b) and Section 3.03(c):<\/p>\n<p>                  (i) during the Standstill Period but after the Effective Time,<br \/>\n         the Equity Holding Entity may acquire beneficial ownership of<br \/>\n         additional shares of Common Stock (A) in the open market, or (B) in<br \/>\n         accordance with the terms of Section 3.04, if after giving effect to<br \/>\n         any acquisition of beneficial ownership of additional shares of Common<br \/>\n         Stock pursuant to clause (A) or (B), BMS&#8217; Beneficial Interest would not<br \/>\n         exceed the Standstill Interest;<\/p>\n<p>                  (ii) if, during the Standstill Period, the Company provides<br \/>\n         material non-public information to a third-party in connection with, or<br \/>\n         begins active negotiation of, a Third-Party Change of Control<br \/>\n         Transaction, the Company shall promptly, and in any event within 2<br \/>\n         Business Days, deliver written notice to BMS to such effect, which<br \/>\n         notice shall to the extent known by the Company set forth the<br \/>\n         percentage of Common Stock which the third-party is seeking to acquire<br \/>\n         pursuant to the Third-Party Change of Control Transaction, and BMS<br \/>\n         shall have the right to make a non-public proposal to the Board to<br \/>\n         acquire additional shares of Common Stock; PROVIDED that (i) BMS shall<br \/>\n         not be required (whether by applicable law or otherwise) to publicly<br \/>\n         disclose, or to amend, modify or supplement any existing public<br \/>\n         disclosure because of, the making of such proposal, and (ii) BMS shall<br \/>\n         not publicly disclose such proposal; PROVIDED FURTHER that<br \/>\n         notwithstanding the foregoing, if a third-party has publicly proposed a<br \/>\n         Third-Party Change of Control Transaction and the Company has provided<br \/>\n         material non-public information to such third-party in connection<br \/>\n         therewith, or has begun active negotiation of such Third-Party Change<br \/>\n         of<\/p>\n<p>                                       16<\/p>\n<p>         Control Transaction, BMS shall have the right to make a public or non-<br \/>\n         public proposal to acquire additional shares of Common Stock, subject<br \/>\n         to the proviso in the penultimate sentence of this paragraph. If the<br \/>\n         Company accepts such BMS proposal, BMS or the Equity Holding Entity may<br \/>\n         acquire additional shares of Common Stock in accordance with the terms<br \/>\n         of such proposal. If the Company rejects such BMS proposal and enters<br \/>\n         into an agreement with respect to a Third-Party Change of Control<br \/>\n         Transaction, BMS may make a public proposal to acquire additional<br \/>\n         shares of Common Stock; PROVIDED that BMS may only acquire beneficial<br \/>\n         ownership of any additional shares of Common Stock in a transaction for<br \/>\n         the acquisition of (i) 100% of the outstanding shares of Common Stock,<br \/>\n         or (ii) the same percentage of the outstanding shares of Common Stock<br \/>\n         which a third-party has agreed to acquire in the Third-Party Change of<br \/>\n         Control Transaction. Notwithstanding the foregoing, BMS&#8217; right to make<br \/>\n         any proposal and to acquire additional shares of Common Stock pursuant<br \/>\n         to this clause (ii) is subject to the condition that the BMS Directors<br \/>\n         recuse themselves from any and all consideration of a Third-Party<br \/>\n         Change of Control Transaction by the Board or any committee thereof;<\/p>\n<p>                  (iii) during the Standstill Period, BMS may acquire beneficial<br \/>\n         ownership of Common Stock if such acquisition has been approved by a<br \/>\n         majority of the Directors that are not BMS Directors; and<\/p>\n<p>                  (iv) during the Standstill Period, BMS shall be permitted to<br \/>\n         make non-public requests to the Board to amend or waive any of the<br \/>\n         limitations set forth in Sections 3.01 or 3.02, which requests the<br \/>\n         Company may accept or reject in its sole discretion; PROVIDED that (i)<br \/>\n         BMS shall not be required (whether by applicable law or otherwise) to<br \/>\n         publicly disclose, or to amend, modify or supplement any existing<br \/>\n         public disclosure because of, the making of such request, and (ii) BMS<br \/>\n         shall not publicly disclose such request; PROVIDED FURTHER that if the<br \/>\n         Company agrees to any such request, and thereafter in connection with<br \/>\n         such amendment or waiver BMS makes a proposal for a merger or business<br \/>\n         combination, or a proposal for an acquisition of shares of Common Stock<br \/>\n         such that, after giving effect to such acquisition, BMS&#8217; Beneficial<br \/>\n         Interest would exceed the Standstill Interest, BMS agrees that any such<br \/>\n         proposal shall be a Complying Proposal.<\/p>\n<p>         (b) Notwithstanding the provisions of Section 3.03(a):<\/p>\n<p>                  (i) to the extent that the Standstill Period is still in<br \/>\n         effect, the exceptions set forth in clauses (i) through (iv) of Section<br \/>\n         3.03(a) shall terminate (if not already terminated) upon the earlier to<br \/>\n         occur of a BMS<\/p>\n<p>                                       17<\/p>\n<p>         Dilution Event or the termination of the Commercial Arrangements by the<br \/>\n         Company pursuant to Section 13.2 of the Commercial Arrangements; and<\/p>\n<p>                  (ii) to the extent that the Standstill Period is still in<br \/>\n         effect, the exception set forth in Section 3.03(a)(ii) shall terminate<br \/>\n         (if not already terminated) upon the earlier to occur of a BMS<br \/>\n         Sell-Down or the termination of the Commercial Arrangements by BMS<br \/>\n         pursuant to Section 13.3 of the Commercial Arrangements; PROVIDED that<br \/>\n         if the exception set forth in Section 3.03(a)(ii) is terminated in<br \/>\n         accordance with this clause (ii), BMS shall be permitted to make a<br \/>\n         proposal to the Company to acquire Common Stock, but only after an<br \/>\n         agreement with respect to a Third-Party Change of Control Transaction<br \/>\n         has been publicly announced by the Company.<\/p>\n<p>         (c) Notwithstanding anything in this Article 3 to the contrary, nothing<br \/>\nshall prohibit the Board from taking any action, or refraining from taking any<br \/>\naction, if the Board reasonably believes that taking such action or refraining<br \/>\nfrom taking such action, as the case may be, is necessary in order to comply<br \/>\nwith its fiduciary duties.<\/p>\n<p>         SECTION 3.04. BMS DILUTION OPTION. (a) During the period in which the<br \/>\nEquity Holding Entity has the right to acquire additional shares of Common Stock<br \/>\npursuant to Section 3.03(a)(i) or, if the Standstill Period is terminated<br \/>\npursuant to clause (iv) of the definition of Standstill Termination Date and<br \/>\nnone of the events referred to in clauses (ii) or (iii) of the definition of<br \/>\nStandstill Termination Date has occurred, the period ending on the fifth<br \/>\nanniversary of the Signing Date (in either case, the &#8220;OVERALL DILUTION OPTION<br \/>\nPERIOD&#8221;), the Company shall deliver a written notice to BMS of the occurrence of<br \/>\na Dilution Reference Date (the &#8220;DILUTION NOTICE&#8221;) within 15 days after (i) the<br \/>\nlast date of each calendar year beginning with calendar year 2002 and the last<br \/>\ndate of the Overall Dilution Option Period (each such date, an &#8220;ANNUAL DILUTION<br \/>\nREFERENCE DATE&#8221;), (ii) any date on which the Company has issued shares of Common<br \/>\nStock not in respect of Outstanding Convertible Securities and where the number<br \/>\nof shares issued pursuant to such issuance represents more than 10% of the<br \/>\nshares of Common Stock outstanding as of the close of business on the<br \/>\nimmediately preceding Business Day (each such date, an &#8220;EXCEPTIONAL STOCK<br \/>\nISSUANCE DATE&#8221;), and (iii) any date on which the Company has issued shares of<br \/>\nCommon Stock that has the effect of reducing BMS&#8217; Common Stock Interest below 5%<br \/>\nor 12.5% where BMS&#8217; Common Stock Interest at the close of business on the<br \/>\nimmediately preceding Business Day was equal to or greater than 5% or 12.5%,<br \/>\nrespectively (each such date, a &#8220;RIGHTS-REDUCING STOCK ISSUANCE DATE&#8221;). Each<br \/>\nDilution Notice shall specify the number of shares of Common Stock outstanding<br \/>\non the relevant Dilution Reference Date, the number of shares of Common Stock<br \/>\nissued<\/p>\n<p>                                       18<\/p>\n<p>by the Company since the previous Dilution Reference Date (or, in the case of<br \/>\nthe first Dilution Notice, since September 18, 2001) and, in the case of an<br \/>\nExceptional Stock Issuance Date, a description of the transaction which gave<br \/>\nrise to such Exceptional Stock Issuance Date. In addition, each party shall<br \/>\npromptly provide the other with such additional information as such party may<br \/>\nreasonably request in order to enable the parties to determine the number of<br \/>\nshares of Common Stock subject to each BMS Dilution Option. For purposes of<br \/>\ndetermining whether a Rights-Reducing Stock Issuance Date has occurred or will<br \/>\noccur pursuant to clause (iii) above, the parties hereto agree that, unless<br \/>\notherwise certified in writing to the Company by BMS (i) the Company shall be<br \/>\nentitled to rely upon information set forth in the Schedule 13D to be filed on<br \/>\nor after the date hereof by BMS with respect to its beneficial ownership of<br \/>\nshares of Common Stock, as the same may be amended from time to time (the &#8220;BMS<br \/>\nSCHEDULE 13D&#8221;), and (ii) the Company shall assume that the number of shares of<br \/>\nCommon Stock &#8220;beneficially owned&#8221; by BMS as set forth in the BMS Schedule 13D is<br \/>\nthe number of &#8220;shares of outstanding Common Stock owned by BMS and its<br \/>\nAffiliates on such date and over which BMS or any of its Affiliates exercises<br \/>\nfull voting control and bears the full economic risk&#8221; for purposes of the<br \/>\ndefinition of &#8220;BMS&#8217; Common Stock Interest&#8221;.<\/p>\n<p>         (b) For each Dilution Period, if BMS&#8217; Ending Dilution Period Interest<br \/>\nis less than BMS&#8217; Greatest Dilution Period Interest, BMS shall have the option<br \/>\n(the &#8220;BMS DILUTION OPTION&#8221;) to purchase (through the Equity Holding Entity) from<br \/>\nthe Company a number of shares of Common Stock equal to (i) the percentage which<br \/>\nis the difference between BMS&#8217; Greatest Dilution Period Interest and BMS&#8217; Ending<br \/>\nDilution Period Interest, multiplied by (ii) the number of outstanding shares of<br \/>\nCommon Stock as of the last day of such Dilution Period.<\/p>\n<p>         (c) BMS may exercise the BMS Dilution Option, in whole or in part, by<br \/>\ndelivery to the Company of written notice of exercise within 30 days of receipt<br \/>\nof a Dilution Notice (the &#8220;BMS DILUTION OPTION EXERCISE NOTICE&#8221;), which notice<br \/>\nshall specify the number of shares of Common Stock to be purchased by BMS and<br \/>\nwhich shall be irrevocable and binding on both parties upon receipt thereof by<br \/>\nthe Company.<\/p>\n<p>         (d) The per share price for shares of Common Stock purchased by BMS and<br \/>\nissued to the Equity Holding Entity pursuant to the BMS Dilution Option (&#8220;BMS<br \/>\nDILUTION OPTION SHARES&#8221;) shall be equal to the average closing price of the<br \/>\nCommon Stock on the Nasdaq for the thirty Nasdaq trading days ending on and<br \/>\nincluding the date on which the BMS Dilution Option Exercise Notice is delivered<br \/>\nto the Company.<\/p>\n<p>                                       19<\/p>\n<p>         (e) Delivery of certificates representing BMS Dilution Option Shares by<br \/>\nthe Company shall be made against payment of the purchase price therefor by wire<br \/>\ntransfer of immediately available funds to such account of the Company as the<br \/>\nCompany shall communicate to BMS. The certificates for the BMS Dilution Option<br \/>\nShares shall be registered in the name of the Equity Holding Entity. Delivery of<br \/>\nsuch certificates and payment of the purchase price therefor shall be at such<br \/>\nplace and on such date as the parties shall mutually agree, but in no event<br \/>\nlater than ten Business Days after receipt by the Company of the BMS Dilution<br \/>\nOption Exercise Notice (or such later date on which any required filings,<br \/>\nconsents or approvals have been made or received, as the case may be).<\/p>\n<p>         (f) To the extent any issuance of shares of Common Stock pursuant to<br \/>\nthe BMS Dilution Option requires any action by or in respect of, filing with, or<br \/>\nconsent of, any governmental body, agency, official or authority (including,<br \/>\nwithout limitation, filings required under the HSR Act and the rules and<br \/>\nregulations of the Nasdaq), the parties hereto will use their reasonable best<br \/>\nefforts to take, or cause to be taken, all actions and to do, or cause to be<br \/>\ndone, all things necessary, proper or advisable under applicable laws and<br \/>\nregulations to consummate the issuance of shares of Common Stock pursuant to the<br \/>\nBMS Dilution Option.<\/p>\n<p>         (g) Any failure by BMS to exercise a BMS Dilution Option shall not<br \/>\naffect BMS&#8217; right to exercise any subsequent BMS Dilution Option in connection<br \/>\nwith any subsequent Dilution Notice in accordance with the terms set forth<br \/>\nabove.<\/p>\n<p>         (h) Each certificate evidencing BMS Dilution Option Shares shall bear a<br \/>\nlegend in substantially the following form:<\/p>\n<p>                   THE SECURITIES REPRESENTED BY THIS<br \/>\n                   CERTIFICATE ARE SUBJECT TO RESTRICTIONS<br \/>\n                   ON TRANSFER AS SET FORTH IN THE<br \/>\n                   STOCKHOLDER AGREEMENT, DATED SEPTEMBER<br \/>\n                   19, 2001, AMONG IMCLONE SYSTEMS<br \/>\n                   INCORPORATED, BRISTOL-MYERS SQUIBB<br \/>\n                   COMPANY AND BRISTOL-MYERS SQUIBB<br \/>\n                   BIOLOGICS COMPANY, A COPY OF WHICH MAY BE<br \/>\n                   OBTAINED FROM THE CORPORATE SECRETARY OF<br \/>\n                   IMCLONE SYSTEMS INCORPORATED.<\/p>\n<p>                   THE SHARES REPRESENTED BY THIS<br \/>\n                   CERTIFICATE HAVE NOT BEEN REGISTERED<\/p>\n<p>                                       20<\/p>\n<p>                   UNDER THE SECURITIES ACT OF 1933, AS<br \/>\n                   AMENDED, AND MAY BE REOFFERED OR SOLD<br \/>\n                   ONLY IF SO REGISTERED OR IF AN EXEMPTION<br \/>\n                   FROM SUCH REGISTRATION IS AVAILABLE.<\/p>\n<p>                          ARTICLE 4<br \/>\n                    TRANSFER RESTRICTIONS<\/p>\n<p>         SECTION 4.01. TRANSFER OF COMMON STOCK. (a) Subject to Section 4.01(d),<br \/>\nprior to the Initial Trigger Date, BMS and the Equity Holding Entity shall not,<br \/>\nand BMS shall cause its Affiliates not to, directly or indirectly, transfer,<br \/>\nsell or otherwise dispose of, or pledge or otherwise encumber, any shares of<br \/>\nCommon Stock or enter into a Hedging Transaction.<\/p>\n<p>         (b) Subject to Section 4.01(d), after the Initial Trigger Date, BMS and<br \/>\nthe Equity Holding Entity shall not, and BMS shall cause its Affiliates not to,<br \/>\ndirectly or indirectly, transfer, sell or otherwise dispose of, or pledge or<br \/>\notherwise encumber, any shares of Common Stock or enter into a Hedging<br \/>\nTransaction, except (i) pursuant to its registration rights set forth in Article<br \/>\n5, (ii) pursuant to Rule 144 promulgated under the Securities Act, or (iii)<br \/>\npursuant to a Hedging Transaction that is permitted under paragraph (c)(iii) of<br \/>\nthis Section.<\/p>\n<p>         (c) Any transfer, sale or disposition pursuant to Section 4.01(b) shall<br \/>\nbe subject to the following limitations:<\/p>\n<p>                  (i) no shares of Common Stock may be transferred, sold or<br \/>\n         pledged to any Person (other than an Institutional Purchaser) or group<br \/>\n         (within the meaning of Section 13(d)(3) of the Exchange Act) if, after<br \/>\n         giving effect to such sale, such Person or group would beneficially own<br \/>\n         (or, in the case of a registered firm commitment underwritten public<br \/>\n         offering, if the lead Underwriter believes after reasonable inquiry<br \/>\n         such person or group would own) more than 5% of the then outstanding<br \/>\n         shares of Common Stock;<\/p>\n<p>                  (ii) no more than 10% of the total outstanding Common Stock<br \/>\n         may be sold in any one registered firm commitment underwritten public<br \/>\n         offering made in accordance with Article 5; and<\/p>\n<p>                  (iii) neither BMS nor any of its Affiliates will in any<br \/>\n         twelve-month period pledge, otherwise encumber, enter into a Hedging<\/p>\n<p>                                       21<\/p>\n<p>         Transaction or, except for transactions that are registered firm<br \/>\n         commitment underwritten public offerings made in accordance with<br \/>\n         Article 5 hereof, transfer, sell or otherwise dispose of, any shares of<br \/>\n         Common Stock, the effect of which, individually or in the aggregate,<br \/>\n         would be to reduce the economic exposure by BMS or its Affiliates by<br \/>\n         the equivalent of more than 10% of the maximum number of shares of<br \/>\n         Common Stock beneficially owned by BMS and its Affiliates at any time<br \/>\n         after the Signing Date.<\/p>\n<p>         (d) Notwithstanding the foregoing, Acquisition Sub may at any time<br \/>\ntransfer all but not less than all of the shares of Common Stock owned by<br \/>\nAcquisition Sub to any one of (i) BMS, (ii) ERS or (iii) a wholly owned<br \/>\nsubsidiary of ERS; PROVIDED that, in the case of transfers pursuant to clause<br \/>\n(ii) or (iii) above, such transferee is a direct wholly owned subsidiary of BMS<br \/>\nor is wholly owned by one or more subsidiaries of BMS, each of which is wholly<br \/>\nowned by BMS; PROVIDED FURTHER that prior to any transfer pursuant to this<br \/>\nSection 4.01(d), such transferee shall have agreed in writing to be bound by the<br \/>\nterms of this Agreement pursuant to documentation reasonably satisfactory to the<br \/>\nCompany; PROVIDED FURTHER that no transfer pursuant to this Section 4.01(d)<br \/>\nshall relieve any transferor from any liability for damages incurred or suffered<br \/>\nby the Company as a result of any breach of this Agreement by such transferor.<br \/>\nUpon any such transfer, the transferee shall be the Equity Holding Entity under<br \/>\nthis Agreement, and shall thereafter have the rights of transfer granted to<br \/>\nAcquisition Sub under this Section 4.01(d).<\/p>\n<p>         (e) Purported transfers, sales or dispositions of, or Hedging<br \/>\nTransactions with respect to, Common Stock that are not in compliance with<br \/>\nArticle 4 shall be of no force and effect.<\/p>\n<p>         (f) Notwithstanding anything herein to the contrary, the transfer, sale<br \/>\nor disposition of, or Hedging Transactions with respect to, shares of Common<br \/>\nStock by BMS or any of its Affiliates (other than pursuant to Section 4.01(d))<br \/>\nshall not result in the transfer of any rights of BMS or the Equity Holding<br \/>\nEntity under this Agreement.<\/p>\n<p>         SECTION 4.02. TRANSFER OF SHARES OF THE EQUITY HOLDING ENTITY. BMS<br \/>\nagrees that, from the date hereof until such date after the Effective Time on<br \/>\nwhich BMS no longer beneficially owns any shares of Common Stock, BMS will<br \/>\nmaintain its direct, or indirect through one or more wholly owned subsidiaries<br \/>\nof BMS, ownership of 100% of the outstanding capital stock of the Equity Holding<br \/>\nEntity and will not transfer, sell, assign or otherwise dispose of, or pledge or<br \/>\notherwise encumber, any shares of capital stock of the Equity Holding Entity or<\/p>\n<p>                                       22<\/p>\n<p>any subsidiary of BMS which directly or indirectly owns any shares of capital<br \/>\nstock of the Equity Holding Entity.<\/p>\n<p>                                    ARTICLE 5<br \/>\n                               REGISTRATION RIGHTS<\/p>\n<p>         SECTION 5.01. REGISTRATION. (a) The Company agrees that, at any time<br \/>\nafter the Initial Trigger Date, upon the request of BMS (a &#8220;DEMAND<br \/>\nREGISTRATION&#8221;), it will file a registration statement (a &#8220;REGISTRATION<br \/>\nSTATEMENT&#8221;) under the Securities Act as to the number of shares of Registrable<br \/>\nSecurities specified in such request; PROVIDED that (i) the Company shall not be<br \/>\nrequired to file more than three Registration Statements that become effective<br \/>\nand remain effective for the period referred to in Section 5.01(b), (ii) the<br \/>\nCompany shall not be obligated to effect more than one Demand Registration in<br \/>\nany twelve-month period, (iii) the Registrable Securities for which a Demand<br \/>\nRegistration has been requested by BMS shall have a value (based on the average<br \/>\nclosing price per share of Common Stock for ten trading days preceding the<br \/>\ndelivery of BMS&#8217; request) of not less that $100,000,000 (or, if less, all of the<br \/>\nshares of Common Stock then held by the Equity Holding Entity), and (iv) the<br \/>\nCompany shall not be required to file a shelf registration statement pursuant to<br \/>\nRule 415 of the Securities Act under this Section 5.01.<\/p>\n<p>         (b) The Company agrees to use its reasonable best efforts (i) to have<br \/>\nany registration of the Registrable Securities declared effective as promptly as<br \/>\npracticable after the filing thereof, and (ii) to keep such registration<br \/>\nstatement effective for a period (up to three months) sufficient to complete the<br \/>\ndistribution of the Registrable Securities. The Company further agrees to<br \/>\nsupplement or make amendments to the Registration Statement, if required (i) to<br \/>\nrespond to the comments of the SEC, if any, (ii) by the registration form<br \/>\nutilized by the Company for such registration or by the instructions applicable<br \/>\nto such registration form, (iii) by the Securities Act or the rules and<br \/>\nregulations thereunder, or (iv) by BMS (or any Underwriter for BMS) with respect<br \/>\nto information concerning BMS or such Underwriter or the plan of distribution to<br \/>\nbe utilized with respect to the Registrable Securities. The Company agrees to<br \/>\nfurnish to BMS copies of any such supplement or amendment prior to its being<br \/>\nused or filed with the SEC.<\/p>\n<p>         (c) In the event an offering of shares of Registrable Securities is a<br \/>\nfully- underwritten firm commitment offering, BMS shall select the lead<br \/>\nUnderwriter and any additional Underwriters in connection with the offering from<br \/>\na list of<\/p>\n<p>                                       23<\/p>\n<p>nationally-recognized investment banks reasonably agreed to between the<br \/>\nCompany and BMS.<\/p>\n<p>         SECTION 5.02. PIGGYBACK REGISTRATION. If the Company proposes to file a<br \/>\nregistration statement under the Securities Act with respect to an offering of<br \/>\nCommon Stock (i) for the Company&#8217;s own account (other than a registration<br \/>\nstatement on S-4 or S-8 or shelf registration statement (or any substitute form<br \/>\nthat may be adopted by the SEC)) or (ii) for the account of any of its holders<br \/>\nof Common Stock, then the Company shall give written notice of such proposed<br \/>\nfiling to BMS as soon as practicable (but in no event less than 10 days before<br \/>\nthe anticipated filing date), and such notice shall offer BMS the opportunity to<br \/>\nregister such number of shares of Registrable Securities as BMS may request on<br \/>\nthe same terms and conditions as the Company&#8217;s or such holder&#8217;s Common Stock (a<br \/>\n&#8220;PIGGYBACK REGISTRATION&#8221;).<\/p>\n<p>         SECTION 5.03. REDUCTION OF OFFERING. Notwithstanding anything contained<br \/>\nherein, if the lead Underwriter of an offering described in Section 5.01 or<br \/>\nSection 5.02 delivers a written opinion to the Company that the size of the<br \/>\noffering that BMS, the Company and any other Persons intend to make is such that<br \/>\nthe success of the offering would be materially and adversely affected, then the<br \/>\nnumber of shares of Common Stock to be offered for the account of BMS shall be<br \/>\nreduced to the extent necessary to reduce the total amount of securities to be<br \/>\nincluded in such offering to the amount recommended by such lead Underwriter;<br \/>\nPROVIDED, that (a) priority in the case of a Demand Registration pursuant to<br \/>\nSection 5.01 shall be (i) first, the securities offered for the account of BMS,<br \/>\n(ii) second, securities offered by the Company for its own account, and (iii)<br \/>\nthird, pro rata among any other securities of the Company requested to be<br \/>\nregistered pursuant to a contractual right of registration; (b) priority in the<br \/>\ncase of a registration initiated by the Company for its own account pursuant to<br \/>\nSection 5.02 shall be (i) first, securities offered by the Company for its own<br \/>\naccount, (ii) second, pro rata among any other securities of the Company<br \/>\nrequested to be registered pursuant to a contractual right of registration<br \/>\n(including securities requested to be registered by BMS pursuant to Section<br \/>\n5.02); and (c) priority in a registration initiated by the Company for the<br \/>\naccount of a holder (other than the Equity Holding Entity) pursuant to Section<br \/>\n5.02 shall be (i) first, securities offered for the account of such holder, (ii)<br \/>\nsecond, securities offered by the Company for its own account, and (iii) third,<br \/>\npro rata among any other securities of the Company requested to be registered<br \/>\npursuant to a contractual right of registration (including securities requested<br \/>\nto be registered by BMS pursuant to Section 5.02).<\/p>\n<p>         SECTION 5.04. REGISTRATION PROCEDURES. Subject to the provisions of<br \/>\nSection 5.01 hereof, in connection with the registration of Registrable<br \/>\nSecurities hereunder, the Company will as promptly as practicable:<\/p>\n<p>                                       24<\/p>\n<p>          (a) furnish to BMS, prior to the filing of a Registration Statement,<br \/>\ncopies of such Registration Statement as is proposed to be filed, and thereafter<br \/>\nsuch number of copies of such Registration Statement, each amendment and<br \/>\nsupplement thereto (in each case including all exhibits thereto and documents<br \/>\nreferred to therein), the prospectus included in such Registration Statement<br \/>\n(including each preliminary prospectus), any and all transmittal letters or<br \/>\nother correspondence with the SEC and such other documents in such quantities as<br \/>\nBMS may reasonably request from time to time in order to facilitate the<br \/>\ndisposition of the Registrable Securities;<\/p>\n<p>          (b) use all reasonable efforts to register or qualify the Registrable<br \/>\nSecurities under such other securities or blue sky laws of such jurisdiction as<br \/>\nBMS reasonably requests and do any and all other acts and things as may be<br \/>\nreasonably necessary or advisable to enable BMS to consummate the disposition in<br \/>\nsuch jurisdictions of the Registrable Securities; PROVIDED that the Company will<br \/>\nnot be required to (i) qualify generally to do business in any jurisdiction<br \/>\nwhere it would not otherwise be required to qualify but for this Section<br \/>\n5.04(b), (ii) subject itself to taxation in any such jurisdiction or (iii)<br \/>\nconsent to general service of process in any such jurisdiction;<\/p>\n<p>          (c) notify BMS, at any time when a prospectus relating thereto is<br \/>\nrequired to be delivered under the Securities Act, of the happening of any event<br \/>\nas a result of which the prospectus included in such Registration Statement or<br \/>\namendment contains an untrue statement of a material fact or omits to state any<br \/>\nmaterial fact required to be stated therein or necessary to make the statements<br \/>\ntherein not misleading, and the Company will prepare a supplement or amendment<br \/>\nto such prospectus so that, as thereafter delivered to the purchasers of the<br \/>\nRegistrable Securities, such prospectus will not contain an untrue statement of<br \/>\na material fact or omit to state any material fact required to be stated therein<br \/>\nor necessary to make the statements therein not misleading;<\/p>\n<p>          (d) use its reasonable efforts to cause the Registrable Securities to<br \/>\nbe registered with or approved by such other governmental agencies or<br \/>\nauthorities as may be necessary by virtue of the business and operations of the<br \/>\nCompany to enable BMS to consummate the disposition of the Registrable<br \/>\nSecurities; PROVIDED that the Company will not be required to (i) qualify<br \/>\ngenerally to do business in any jurisdiction where it would not otherwise be<br \/>\nrequired to qualify but for this Section 5.04(d), (ii) subject itself to<br \/>\ntaxation in any such jurisdiction or (iii) consent to general service of process<br \/>\nin any such jurisdiction;<\/p>\n<p>          (e) enter into customary agreements (including an underwriting<br \/>\nagreement in customary form) and take such other actions as are reasonably<\/p>\n<p>                                       25<\/p>\n<p>required in order to expedite or facilitate the disposition of the Registrable<br \/>\nSecurities;<\/p>\n<p>          (f) make available for inspection by BMS, any underwriter<br \/>\nparticipating in any disposition pursuant to such registration, and any<br \/>\nattorney, accountant or other agent retained by BMS or any such underwriter<br \/>\n(collectively, the &#8220;INSPECTORS&#8221;), all financial and other records, pertinent<br \/>\ncorporate documents and properties of the Company (collectively, the &#8220;RECORDS&#8221;)<br \/>\nas shall be reasonably necessary to enable them to exercise their due diligence<br \/>\nresponsibility, and cause the officers, directors and employees of the Company<br \/>\nto supply all information reasonably requested by any such Inspector in<br \/>\nconnection with such registration; PROVIDED that (i) Records and information<br \/>\nobtained hereunder shall be used by such persons only to exercise their due<br \/>\ndiligence responsibility and (ii) Records or information which the Company<br \/>\ndetermines, in good faith, to be confidential shall not be disclosed by the<br \/>\nInspectors unless (x) the disclosure of such Records is necessary to avoid or<br \/>\ncorrect a material misstatement or omission in the Registration Statement or (y)<br \/>\nthe release of such Records or information is ordered pursuant to a subpoena or<br \/>\nother order from a court or governmental authority of competent jurisdiction.<\/p>\n<p>          (g) use all reasonable efforts to obtain a comfort letter from the<br \/>\nindependent public accountants for the Company in customary form and covering<br \/>\nsuch matters of the type customarily covered by comfort letters as BMS<br \/>\nreasonably requests;<\/p>\n<p>          (h) otherwise use all reasonable efforts to comply with all applicable<br \/>\nrules and regulations of the SEC, and make generally available to its security<br \/>\nholders, as soon as reasonably practicable, an earnings statement covering a<br \/>\nperiod of twelve months, beginning within three months after the effective date<br \/>\nof the registration, which earnings statement shall satisfy the provisions of<br \/>\nSection 11(a) of the Securities Act and Rule 158 thereunder; and<\/p>\n<p>          (i) use all reasonable efforts to cause all Registrable Securities to<br \/>\nbe listed on each securities exchange or automated quotation system on which<br \/>\nsimilar securities issued by the Company are listed.<\/p>\n<p>         SECTION 5.05. CONDITIONS TO OFFERINGS. The obligations of the Company<br \/>\nto take the actions contemplated by Sections 5.01, 5.02 and 5.04 with respect to<br \/>\nan offering of Registrable Securities shall be subject to the following<br \/>\nconditions:<\/p>\n<p>                  (i) BMS and the Equity Holding Entity shall conform to all<br \/>\n         applicable requirements of the Securities Act and the Exchange Act with<br \/>\n         respect to the offering and sale of securities; and<\/p>\n<p>                                       26<\/p>\n<p>                  (ii) BMS shall advise each Underwriter through which any of<br \/>\n         the Registrable Securities are offered that the Registrable Securities<br \/>\n         are part of a distribution that is subject to the prospectus delivery<br \/>\n         requirements of the Securities Act.<\/p>\n<p>         The Company may require BMS to furnish to the Company such information<br \/>\nregarding BMS or the distribution of the Registrable Securities as the Company<br \/>\nmay from time to time reasonably request in writing, in each case only as<br \/>\nrequired by the Securities Act or the rules and regulations thereunder or under<br \/>\nstate securities or blue sky laws.<\/p>\n<p>         BMS agrees that, upon receipt of any notice from the Company of the<br \/>\nhappening of any event of the kind described in Section 5.04(c) hereof, BMS will<br \/>\nforthwith discontinue disposition of Registrable Securities pursuant to the<br \/>\nregistration covering such shares of Common Stock until BMS&#8217; receipt of the<br \/>\ncopies of the supplemented or amended prospectus contemplated by Section 5.04(c)<br \/>\nhereof and, if so directed by the Company, will promptly deliver to the Company<br \/>\nall copies (other than any permanent file copies then in BMS&#8217; possession) of the<br \/>\nmost recent prospectus covering such Registrable Securities at the time of<br \/>\nreceipt of such notice.<\/p>\n<p>         SECTION 5.06. ADDITIONAL CONDITIONS. (a) The Company&#8217;s obligations<br \/>\npursuant to Sections 5.01 and 5.02 shall be suspended if (i) the fulfillment of<br \/>\nsuch obligations would require the Company to make a disclosure that would, in<br \/>\nthe reasonable good faith judgment of the Company&#8217;s board of directors, be<br \/>\ndetrimental to the Company and premature, (ii) the Company has filed a<br \/>\nregistration statement with respect to securities to be distributed in an<br \/>\nunderwritten public offering and it is advised by its lead or managing<br \/>\nunderwriter that an offering by BMS of the Registrable Securities would<br \/>\nmaterially adversely affect the distribution of such equity securities, or (iii)<br \/>\nthe fulfillment of such obligations would require the Company to prepare audited<br \/>\nfinancial statements not required to be prepared for the Company to comply with<br \/>\nits obligations under the Exchange Act as of any date not coincident with the<br \/>\nlast day of any fiscal year of the Company. Such obligations shall be reinstated<br \/>\n(x) in the case of clause (i) above, upon the making of such disclosure by the<br \/>\nCompany (or, if earlier, when such disclosure would either no longer be<br \/>\nnecessary for the fulfillment of such obligations or no longer be detrimental),<br \/>\n(y) in the case of clause (ii) above, upon the conclusion of any period during<br \/>\nwhich the Company would not, pursuant to the terms of its underwriting<br \/>\narrangements, be permitted to sell the Registrable Securities for its own<br \/>\naccount and (z) in the case of clause (iii) above, as soon as it would no longer<br \/>\nbe necessary to prepare such financial statements to comply with the Securities<br \/>\nAct.<\/p>\n<p>                                       27<\/p>\n<p>          (b) The number of shares of Registrable Securities to be registered<br \/>\npursuant to Section 5.01 for an offering that is not a fully-underwritten firm<br \/>\ncommitment offering shall be reduced to the extent that the Company is advised<br \/>\nin writing by an investment banker of national standing that the sale of all<br \/>\nshares of Common Stock requested to be registered by BMS would materially and<br \/>\nadversely affect the market price of the Common Stock.<\/p>\n<p>         SECTION 5.07. REGISTRATION EXPENSES. All fees and expenses incident to<br \/>\nthe performance of or compliance with this Article 5 by the Company, including,<br \/>\nwithout limitation, all fees and expenses of compliance with securities or blue<br \/>\nsky laws (including reasonable fees and disbursements of counsel in connection<br \/>\nwith blue sky qualifications of the Registrable Securities), rating agency fees,<br \/>\nprinting expenses, messenger and delivery expenses, any registration or filing<br \/>\nfees payable under any federal or state securities or blue sky laws, the fees<br \/>\nand expenses incurred in connection with any listing of the securities to be<br \/>\nregistered on any securities exchange or automated quotation system, fees and<br \/>\ndisbursements of counsel for the Company and its independent certified public<br \/>\naccountants (including the expenses of any comfort letters required by or<br \/>\nincident to such performance), securities acts liability insurance (if the<br \/>\nCompany elects to obtain such insurance), the reasonable fees and expenses of<br \/>\nany special experts retained by the Company in connection with such registration<br \/>\nand the fees and expenses of other persons retained by the Company (all such<br \/>\nexpenses being herein called &#8220;REGISTRATION EXPENSES&#8221;), will be (i) divided<br \/>\nequally between the Company and BMS with respect to the first and second Demand<br \/>\nRegistrations and (ii) borne by BMS with respect to a third Demand Registration;<br \/>\nit being understood and agreed that BMS will bear all fees and expenses incurred<br \/>\nby it in connection with any registration pursuant to this Article 5 (including,<br \/>\nwithout limitation, underwriting fees, discounts and commissions, transfer<br \/>\ntaxes, and fees and expenses of its counsel).<\/p>\n<p>         SECTION 5.08. INDEMNIFICATION; CONTRIBUTION. (a) INDEMNIFICATION BY THE<br \/>\nCOMPANY. The Company agrees to indemnify, to the fullest extent permitted by<br \/>\nlaw, BMS, its directors and officers and each person who controls BMS (within<br \/>\nthe meaning of either the Securities Act or the Exchange Act) against any and<br \/>\nall losses, claims, damages, liabilities and expenses (including reasonable<br \/>\nattorneys&#8217; fees) caused by any untrue or alleged untrue statement of material<br \/>\nfact contained in any Registration Statement, prospectus or preliminary<br \/>\nprospectus (each as amended and or supplemented, if the Company shall have<br \/>\nfurnished any amendments or supplements thereto), or any omission or alleged<br \/>\nomission to state therein a material fact required to be stated therein or<br \/>\nnecessary to make the statements therein (in the case of a prospectus, in the<br \/>\nlight of the circumstances under which they were made) not misleading, PROVIDED<br \/>\nthat the Company shall not be required to indemnify BMS or its officers,<br \/>\ndirectors or controlling persons<\/p>\n<p>                                       28<\/p>\n<p>for any losses, claims, damages, liabilities or expenses resulting from any such<br \/>\nuntrue statement or omission if such untrue statement or omission is made in<br \/>\nreliance on and in conformity with any information with respect to BMS or such<br \/>\nother parties furnished to the Company by BMS or such other parties expressly<br \/>\nfor use therein. In connection with an underwritten offering, the Company will<br \/>\nindemnify each Underwriter, the officers and directors of such Underwriter, and<br \/>\neach person who controls such Underwriter (within the meaning of either the<br \/>\nSecurities Act or Exchange Act) to the same extent as provided above with<br \/>\nrespect to the indemnification of BMS; PROVIDED that such Underwriter agrees to<br \/>\nindemnify the Company to the same extent as provided below with respect to the<br \/>\nindemnification of the Company by BMS.<\/p>\n<p>         (b) INDEMNIFICATION BY BMS. In connection with any registration in<br \/>\nwhich BMS is participating, BMS will furnish to the Company in writing such<br \/>\ninformation and affidavits with respect to BMS as the Company reasonably<br \/>\nrequests for use in connection with any such registration, prospectus, or<br \/>\npreliminary prospectus and agrees to indemnify the Company, its directors, its<br \/>\nofficers who sign the Registration Statement and each person, if any, who<br \/>\ncontrols the Company (within the meaning of either the Securities Act or of the<br \/>\nExchange Act) to the same extent as the foregoing indemnity from the Company to<br \/>\nBMS, but only with respect to information relating to BMS furnished to the<br \/>\nCompany in writing by BMS expressly for use in the Registration Statement, the<br \/>\nprospectus, any amendment or supplement thereto, or any preliminary prospectus.<\/p>\n<p>         (c) CONDUCT OF INDEMNIFICATION PROCEEDINGS. In case any proceeding<br \/>\n(including any governmental investigation) shall be instituted involving any<br \/>\nperson in respect of which indemnity may be sought pursuant to Section 5.08(a)<br \/>\nor (b), such person (hereinafter called the indemnified party) shall promptly<br \/>\nnotify the person against whom such indemnity may be sought (hereinafter called<br \/>\nthe indemnifying party) in writing and the indemnifying party, upon request of<br \/>\nthe indemnified party, shall retain counsel reasonably satisfactory to the<br \/>\nindemnified party to represent the indemnified party and any others the<br \/>\nindemnifying party may designate in such proceeding and shall pay the fees and<br \/>\ndisbursements of such counsel related to such proceeding. In any such<br \/>\nproceeding, any indemnified party shall have the right to retain its own<br \/>\ncounsel, but the fees and expenses of such counsel shall be at the expense of<br \/>\nsuch indemnified party unless (i) the indemnifying party and the indemnified<br \/>\nparty shall have mutually agreed to the retention of such counsel or (ii) the<br \/>\nnamed parties to any such proceeding (including any impleaded parties) include<br \/>\nboth the indemnifying party and the indemnified party and the indemnified party<br \/>\nshall have been advised by counsel that representation of both parties by the<br \/>\nsame counsel would be inappropriate due to actual or potential differing<br \/>\ninterests between them. It is understood that the indemnifying party shall not,<br \/>\nin connection with any proceeding or related<\/p>\n<p>                                       29<\/p>\n<p>proceedings in the same jurisdiction, be liable for the fees and expenses of<br \/>\nmore than one separate firm (in addition to any local counsel) for all such<br \/>\nindemnified parties, and that all such fees and expenses shall be reimbursed as<br \/>\nthey are incurred. In the case of any such separate firm for the indemnified<br \/>\nparties, such firm shall be designated in writing by the indemnified parties.<br \/>\nThe indemnifying party shall not be liable for any settlement of any proceeding<br \/>\neffected without its written consent, but if settled with such consent or if<br \/>\nthere be a final judgment for the plaintiff, the indemnifying party agrees to<br \/>\nindemnify the indemnified party from and against any loss or liability by reason<br \/>\nof such settlement or judgment. Notwithstanding the foregoing sentence, if at<br \/>\nany time an indemnified party shall have requested an indemnifying party to<br \/>\nreimburse the indemnified party for fees and expenses of counsel as contemplated<br \/>\nby the third sentence of this Section 5.08(c), the indemnifying party agrees<br \/>\nthat it shall be liable for any settlement of any proceeding effected without<br \/>\nits written consent if (i) such settlement in entered into more than 30 days<br \/>\nafter receipt by such indemnifying party of the aforesaid request and (ii) such<br \/>\nindemnifying party shall not have reimbursed the indemnified party in accordance<br \/>\nwith such request or reasonably objected in writing, on the basis of the<br \/>\nstandards set forth herein, to the propriety of such reimbursement prior to the<br \/>\ndate of such settlement. No indemnifying party shall, without the prior written<br \/>\nconsent of the indemnified party, effect any settlement of any pending or<br \/>\nthreatened proceeding in respect of which any indemnified party is or could have<br \/>\nbeen a party and indemnity could have been sought hereunder by such indemnified<br \/>\nparty, unless such settlement includes an unconditional release of such<br \/>\nindemnified party from all liability on claims that are the subject matter of<br \/>\nsuch proceeding.<\/p>\n<p>         (d) CONTRIBUTION. If the indemnification provided for in this Section<br \/>\n5.08 from the indemnifying party is unavailable to an indemnified party<br \/>\nhereunder in respect of any losses, claims, damages, liabilities or expenses<br \/>\nreferred to in this Section 5.08, then the indemnifying party, in lieu of<br \/>\nindemnifying such indemnified party, shall contribute to the amount paid or<br \/>\npayable by such indemnified party as a result of such losses, claims, damages,<br \/>\nliabilities or expenses in such proportion as is appropriate to reflect the<br \/>\nrelative fault of the indemnifying party and indemnified parties in connection<br \/>\nwith the actions which resulted in such losses, claims, damages, liabilities or<br \/>\nexpenses, as well as any other relevant equitable considerations. The relative<br \/>\nfault of such indemnifying party and indemnified parties shall be determined by<br \/>\nreference to, among other things, whether any action in question, including any<br \/>\nuntrue or alleged untrue statement of a material fact or omission or alleged<br \/>\nomission to state a material fact, has been made by, or relates to information<br \/>\nsupplied by, such indemnifying party or indemnified parties, and the parties&#8217;<br \/>\nrelative intent, knowledge, access to information and opportunity to correct or<br \/>\nprevent such action. The amount paid or payable by a party as a result of the<br \/>\nlosses, claims,<\/p>\n<p>                                       30<\/p>\n<p>damages, liabilities and expenses referred to above shall be deemed to include,<br \/>\nsubject to the limitations set forth in Section 5.08(c), any legal or other fees<br \/>\nor expenses reasonably incurred by such party in connection with any<br \/>\ninvestigation or proceeding.<\/p>\n<p>         The parties hereto agree that it would not be just and equitable if<br \/>\ncontribution pursuant to this Section 5.08(d) were determined by PRO RATA<br \/>\nallocation or by any other method of allocation which does not take into account<br \/>\nthe equitable considerations referred to in this Section 5.08(d). No person<br \/>\nguilty of fraudulent misrepresentation (within the meaning of Section 11(f) of<br \/>\nthe Securities Act) shall be entitled to contribution from any person who was<br \/>\nnot guilty of such fraudulent misrepresentation.<\/p>\n<p>         If indemnification is available under this Section 5.08, the<br \/>\nindemnifying parties shall indemnify each indemnified party to the full extent<br \/>\nprovided in Sections 5.08(a) and (b) without regard to the relative fault of<br \/>\nsaid indemnifying party or indemnified party or any other equitable<br \/>\nconsideration provided for in this Section 5.08(d).<\/p>\n<p>         SECTION 5.09. RULE 144. The Company agrees that it will file the<br \/>\nreports required to be filed by it under the Securities Act and the Exchange Act<br \/>\nand the rules and regulations adopted by the SEC thereunder, and it will take<br \/>\nsuch further action as BMS reasonably may request, all to the extent required<br \/>\nfrom time to time to enable BMS to sell Common Stock within the limitation of<br \/>\nthe exemptions provided by (a) Rule 144 under the Securities Act, as such Rule<br \/>\nmay be amended from time to time, or (b) any similar rule or regulation<br \/>\nhereafter adopted by the SEC. Upon the request of BMS, the Company will deliver<br \/>\nto BMS a written statement as to whether it has complied with such requirements.<\/p>\n<p>         SECTION 5.10. LOCKUP. If and to the extent requested by the managing<br \/>\nunderwriters of an underwritten public offering of equity securities of the<br \/>\nCompany, the Company, BMS and the Equity Holding Entity agree not to effect, and<br \/>\nto cause their respective Affiliates not to effect, except as part of such<br \/>\nregistration, any offer, sale, pledge, transfer or other distribution or<br \/>\ndisposition or any agreement with respect to the foregoing, of the issue being<br \/>\nregistered or a similar security of the Company, or any securities convertible<br \/>\ninto or exchangeable or exercisable for such securities, including a sale<br \/>\npursuant to Rule 144, during the seven day period prior to and during such<br \/>\nperiod that the lead Underwriter may reasonably request, no greater than 90<br \/>\ndays, beginning on the effective date of such registration.<\/p>\n<p>                                       31<\/p>\n<p>                                    ARTICLE 6<br \/>\n                                  MISCELLANEOUS<\/p>\n<p>         SECTION 6.01. NOTICES. All notices, requests and other communications<br \/>\nto any party hereunder shall be in writing (including facsimile transmission)<br \/>\nand shall be given,<\/p>\n<p>         if to the Company, to:<\/p>\n<p>         ImClone Systems Incorporated<br \/>\n         180 Varick Street, 7th Floor<br \/>\n         New York, New York 10014<br \/>\n         Attn: John Landes, Esq.<br \/>\n               General Counsel<br \/>\n         Fax: (212) 645-2054<\/p>\n<p>         with a copy to:<\/p>\n<p>         Davis Polk &amp; Wardwell<br \/>\n         450 Lexington Avenue<br \/>\n         New York, New York 10017<br \/>\n         Attn: Phillip R. Mills, Esq.<br \/>\n         Fax: (212) 450-4800<\/p>\n<p>         if to BMS or Acquisition Sub, to:<\/p>\n<p>         Bristol-Myers Squibb Company<br \/>\n         345 Park Avenue<br \/>\n         New York, New York 10154<br \/>\n         Attn: General Counsel<br \/>\n         Fax: (212) 546-4020<\/p>\n<p>         with a copy to:<\/p>\n<p>         Cravath, Swaine &amp; Moore<br \/>\n         Worldwide Plaza<br \/>\n         825 Eighth Avenue<br \/>\n         New York, NY 10019<br \/>\n         Attn: Susan Webster, Esq.<br \/>\n         Fax: (212) 474-3700<\/p>\n<p>or such other address or facsimile number as such party may hereafter specify<br \/>\nfor the purpose by notice to the other parties hereto. All such notices,<br \/>\nrequests and<\/p>\n<p>                                       32<\/p>\n<p>other communications shall be deemed received on the date of receipt by the<br \/>\nrecipient thereof if received prior to 5 p.m. in the place of receipt and such<br \/>\nday is a Business Day in the place of receipt. Otherwise, any such notice,<br \/>\nrequest or communication shall be deemed not to have been received until the<br \/>\nnext succeeding Business Day in the place of receipt.<\/p>\n<p>         SECTION 6.02. AMENDMENTS; WAIVERS. (a) Any provision of this Agreement<br \/>\nmay be amended or waived if, but only if, such amendment or waiver is in writing<br \/>\nand is signed, in the case of an amendment, by each party to this Agreement or,<br \/>\nin the case of a waiver, by each party against whom the waiver is to be<br \/>\neffective.<\/p>\n<p>          (b) No failure or delay by any party in exercising any right, power or<br \/>\nprivilege hereunder shall operate as a waiver thereof nor shall any single or<br \/>\npartial exercise thereof preclude any other or further exercise thereof or the<br \/>\nexercise of any other right, power or privilege. The rights and remedies herein<br \/>\nprovided shall be cumulative and not exclusive of any rights or remedies<br \/>\nprovided by law.<\/p>\n<p>         SECTION 6.03. SUCCESSORS AND ASSIGNS. The provisions of this Agreement<br \/>\nshall be binding upon and inure to the benefit of the parties hereto and their<br \/>\nrespective successors and assigns, provided that, except as provided in Section<br \/>\n4.01(d), no party may assign, delegate or otherwise transfer any of its rights<br \/>\nor obligations under this Agreement without the consent of each other party<br \/>\nhereto.<\/p>\n<p>         SECTION 6.04.  CAPTIONS.  The captions herein are included for<br \/>\nconvenience of reference only and shall be ignored in the construction or<br \/>\ninterpretation hereof.<\/p>\n<p>         SECTION 6.05. SEVERABILITY. If any term, provision, covenant or<br \/>\nrestriction of this Agreement is held by a court of competent jurisdiction or<br \/>\nother authority to be invalid, void or unenforceable, the remainder of the<br \/>\nterms, provisions, covenants and restrictions of this Agreement shall remain in<br \/>\nfull force and effect and shall in no way be affected, impaired or invalidated<br \/>\nso long as the economic or legal substance of the transactions contemplated<br \/>\nhereby is not affected in any manner materially adverse to any party. Upon such<br \/>\na determination, the parties shall negotiate in good faith to modify this<br \/>\nAgreement so as to effect the original intent of the parties as closely as<br \/>\npossible in an acceptable manner in order that the transactions contemplated<br \/>\nhereby be consummated as originally contemplated to the fullest extent possible.<\/p>\n<p>         SECTION 6.06.  SPECIFIC PERFORMANCE. The parties hereto agree that<br \/>\nirreparable damage would occur if any provision of this Agreement were not<br \/>\nperformed in accordance with the terms hereof and that the parties shall be<\/p>\n<p>                                       33<\/p>\n<p>entitled to an injunction or injunctions to prevent breaches of this Agreement<br \/>\nor to enforce specifically the performance of the terms and provisions hereof in<br \/>\nany federal court located in the State of New York or, to the extent no such<br \/>\nfederal court has jurisdiction over such proceeding, any New York state court,<br \/>\nin addition to any other remedy to which they are entitled at law or in equity.<\/p>\n<p>         SECTION 6.07. GOVERNING LAW. This Agreement shall be governed by and<br \/>\nconstrued in accordance with the laws of the State of New York, without regard<br \/>\nto the conflicts of laws rules of such state.<\/p>\n<p>         SECTION 6.08. JURISDICTION. Any suit, action or proceeding seeking to<br \/>\nenforce any provision of, or based on any matter arising out of or in connection<br \/>\nwith, this Agreement or the transactions contemplated hereby may be brought in<br \/>\nany federal court located in the State of New York or, to the extent no such<br \/>\nfederal court has jurisdiction over such action, suit or proceeding, any New<br \/>\nYork state court, and each of the parties hereby consents to the jurisdiction of<br \/>\nsuch courts (and of the appropriate appellate courts therefrom) in any such<br \/>\nsuit, action or proceeding and irrevocably waives, to the fullest extent<br \/>\npermitted by law, any objection that it may now or hereafter have to the laying<br \/>\nof the venue of any such suit, action or proceeding in any such court or that<br \/>\nany such suit, action or proceeding brought in any such court has been brought<br \/>\nin an inconvenient form. Process in any such suit, action or proceeding may be<br \/>\nserved on any party anywhere in the world, whether within or without the<br \/>\njurisdiction of any such court. Without limiting the foregoing, each party<br \/>\nagrees that service of process on such party as provided in Section 6.01 shall<br \/>\nbe deemed effective service of process on such party.<\/p>\n<p>         SECTION 6.09. WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO HEREBY<br \/>\nIRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING<br \/>\nARISING OUT OF OR RELATED TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED<br \/>\nHEREBY.<\/p>\n<p>         SECTION 6.10. COUNTERPARTS; EFFECTIVENESS; BENEFIT. This Agreement may<br \/>\nbe signed in any number of counterparts, each of which shall be an original,<br \/>\nwith the same effect as if the signatures thereto and hereto were upon the same<br \/>\ninstrument. This Agreement shall become effective when each party hereto shall<br \/>\nhave received counterparts hereof signed by all of the other parties hereto. No<br \/>\nprovision of this Agreement is intended to confer any rights, benefits,<br \/>\nremedies, obligations, or liabilities hereunder upon any Person other than the<br \/>\nparties hereto and their respective successors and assigns.<\/p>\n<p>                                       34<\/p>\n<p>         SECTION 6.11. ENTIRE AGREEMENT. This Agreement, the Confidentiality<br \/>\nAgreement, the Commercial Arrangements, the Acquisition Agreement and the<br \/>\ndisclosure letter referred to in Article 4 of the Acquisition Agreement<br \/>\nconstitute the entire agreement between the parties with respect to the subject<br \/>\nmatter of this Agreement and supersede all prior agreements and understandings,<br \/>\nboth oral and written, between the parties with respect to the subject matter of<br \/>\nthis Agreement.<\/p>\n<p>         SECTION 6.12. EXPENSES. Except as otherwise provided herein, all costs<br \/>\nand expenses incurred in connection with this Agreement shall be paid by the<br \/>\nparty incurring such cost or expense.<\/p>\n<p>         SECTION 6.13. ADDITIONAL COVENANT OF BMS. BMS shall take all action<br \/>\nnecessary to cause the Equity Holding Entity to perform its obligations under<br \/>\nthis Agreement, including without limitation, providing funding to the Equity<br \/>\nHolding Entity to the extent necessary for the Equity Holding Entity to fulfill<br \/>\nits obligations hereunder.<\/p>\n<p>                                       35<\/p>\n<p>         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as<br \/>\nof the date first above written.<\/p>\n<p>                            BRISTOL-MYERS SQUIBB COMPANY<\/p>\n<p>                            By:   \/s\/ Brian Markison<br \/>\n                               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n                               Name: Brian Markison<br \/>\n                               Title: Senior Vice President &#8211; External Affairs,<br \/>\n                                      Worldwide Medicines Group<\/p>\n<p>                            BRISTOL-MYERS SQUIBB BIOLOGICS<br \/>\n                             COMPANY<\/p>\n<p>                            By:   \/s\/ Sandra Leung<br \/>\n                               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n                               Name: Sandra Leung<br \/>\n                               Title: Corporate Secretary<\/p>\n<p>                            IMCLONE SYSTEMS INCORPORATED<\/p>\n<p>                            By:   \/s\/ Samuel D. Waskal, Ph.D.<br \/>\n                               &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;<br \/>\n                               Name: Samuel D. Waskal, Ph.D.<br \/>\n                               Title: President and Chief Executive Officer<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_stopmodifiedupdate":true,"_modified_date":"","_cloudinary_featured_overwrite":false},"corporate_contracts_companies":[6948,7835],"corporate_contracts_industries":[9405,9407],"corporate_contracts_types":[9629,9633],"class_list":["post-43937","corporate_contracts","type-corporate_contracts","status-publish","hentry","corporate_contracts_companies-bristol-myers-squibb-co","corporate_contracts_companies-imclone-inc","corporate_contracts_industries-drugs__biotech","corporate_contracts_industries-drugs__pharma","corporate_contracts_types-securities","corporate_contracts_types-securities__shareholder"],"acf":[],"_links":{"self":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts\/43937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts"}],"about":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/types\/corporate_contracts"}],"wp:attachment":[{"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/media?parent=43937"}],"wp:term":[{"taxonomy":"corporate_contracts_companies","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_companies?post=43937"},{"taxonomy":"corporate_contracts_industries","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_industries?post=43937"},{"taxonomy":"corporate_contracts_types","embeddable":true,"href":"https:\/\/corporate.findlaw.com\/legal-api\/wp-json\/wp\/v2\/corporate_contracts_types?post=43937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}